Dietary Goji Shapes the Gut Microbiota to Prevent the Liver Injury Induced by Acute Alcohol Intake

Guo, Lin; Guan, Qijie; Duan, Wenhui; Ren, Yilin; Zhang, Xiaojuan; Xu, Huaide; Shi, Jin‐Song; Wang, Fang-Zhou; Lu, Ran; Zhang, Huiling; Xu, Zhenghong; Li, Huazhong; Geng, Yan

doi:10.3389/fnut.2022.929776

Cited by 20 publications

(24 citation statements)

References 72 publications

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“…Meanwhile, we found that wolfberry decreased the LPS content and ameliorated liver injury induced by APAP in DILI mice. Similarly, wolfberry inhibited liver injury induced by alcohol intake and maintained the intestinal barrier in mice by shaping the gut microbiome, especially enhancing A. muciniphila 46 . Meanwhile, Lycium barbarum polysaccharide, the central bioactive molecule of wolfberry, prevent di(2‐Ethylhexyl) phthalate (DEHP)‐induced hepatotoxicity 47 .…”

Section: Discussionmentioning

confidence: 99%

“…Similarly, wolfberry inhibited liver injury induced by alcohol intake and maintained the intestinal barrier in mice by shaping the gut microbiome, especially enhancing A. muciniphila. 46 Meanwhile, Lycium barbarum polysaccharide, the central bioactive molecule of wolfberry, prevent di(2-Ethylhexyl) phthalate (DEHP)-induced hepatotoxicity. 47 Wolfberry was rich in polyphenol compounds.…”

Section: Wolfberry Increased the Abundance Of A Muciniphila In The Co...mentioning

confidence: 99%

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Wolfberry enhanced the abundance of Akkermansia muciniphila by YAP1 in mice with acetaminophen‐induced liver injury

et al. 2022

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Drug‐induced liver injury (DILI) by acetaminophen (APAP) was one of the most challenging liver diseases. Wolfberry (Lycium barbarum L.), a traditional Chinese medicinal material and food supplement, has a potential effect on increasing the abundance of Akkermansia muciniphila (A. muciniphila) in mice colons. However, the effect and mechanism of wolfberry remain unclear in APAP‐induced DILI. In this study, wolfberry promoted the proliferation of activated‐A. muciniphila in vitro and in vivo. For the first time, we detected that the activated‐A. muciniphila but not the killed‐A. muciniphila increased the expression level of Yes‐associated protein 1 (YAP1) in the liver and alleviated liver injury in APAP‐induced DILI mice. Mechanically, A. muciniphila improved the intestinal mucosal barrier and reduced lipopolysaccharide (LPS) content in the liver, leading to the increased expression level of YAP1. Furthermore, wolfberry increased the A. muciniphila abundance in the colon and YAP1 expression in the liver from APAP‐induced DILI mice, which promoted the recovery of APAP‐induced liver injury. Meanwhile, wolfberry combination with A. muciniphila synergistically increased AKK abundance and YAP1 expression in the liver. Our research provides an innovative strategy to improve DILI.

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Section: Discussionmentioning

confidence: 99%

Section: Wolfberry Increased the Abundance Of A Muciniphila In The Co...mentioning

confidence: 99%

Wolfberry enhanced the abundance of Akkermansia muciniphila by YAP1 in mice with acetaminophen‐induced liver injury

et al. 2022

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“…Ruminococcaceae_UCG-014 can produce butyrate, an important energy source for colon cells. In the meantime, they can increase short-chain fatty acids and affect host appetite and satiety through different mechanisms, delaying gastric emptying and thus energy absorption ( Canfora et al, 2015 ; Guo et al, 2022 ). Ruminiclostridium is positively correlated with acetate content in the cecum, providing more energy to the host ( Zhang et al, 2021c ).…”

Section: Discussionmentioning

confidence: 99%

Does diet or macronutrients intake drive the structure and function of gut microbiota?

Yan²,

Fu³

et al. 2023

Front. Microbiol.

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Shift of ingestive behavior is an important strategy for animals to adapt to change of the environment. We knew that shifts in animal dietary habits lead to changes in the structure of the gut microbiota, but we are not sure about if changes in the composition and function of the gut microbiota respond to changes in the nutrient intake or food items. To investigate how animal feeding strategies affect nutrient intakes and thus alter the composition and digestion function of gut microbiota, we selected a group of wild primate group for the study. We quantified their diet and macronutrients intake in four seasons of a year, and instant fecal samples were analyzed by high-throughput sequencing of 16S rRNA and metagenomics. These results demonstrated that the main reason that causes seasonal shifts of gut microbiota is the macronutrient variation induced by seasonal dietary differences. Gut microbes can help to compensate for insufficient macronutrients intake of the host through microbial metabolic functions. This study contributes to a deeper understanding of the causes of seasonal variation in host-microbial variation in wild primates.

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“…Unlike the CAC model, YYFZBJS increased the abundance of Lactobacillus, Ruminococcaceae, and Clostridium, but decreased the abundance of enterotoxigenic Bacteroides fragilis (ETBF) in a dose-dependent manner. Interestingly, all three added bacteria could produce butyric acid (Guo et al, 2022;Ávila et al, 2023). Ruminococcaceae can regulate secondary BAs, promote the malignant progress of inflammation (Sinha et al, 2020), and may play a role in anti-tumor immunity (Peng et al, 2020).…”

Section: Intervention With Crosstalk Among Intestinal Microbiota Infl...mentioning

confidence: 99%

Advances in research on the effectiveness and mechanism of Traditional Chinese Medicine formulas for colitis-associated colorectal cancer

Wei

Leng²,

Li³

et al. 2023

Front. Pharmacol.

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Inflammatory bowel disease (IBD) can progress into colitis-associated colorectal cancer (CAC) through the inflammation-cancer sequence. Although the mechanism of carcinogenesis in IBD has not been fully elucidated, the existing research indicates that CAC may represent a fundamentally different pathogenesis pattern of colorectal cancer. At present, there is no proven safe and effective medication to prevent IBD cancer. In recent years, Chinese medicine extracts and Chinese medicine monomers have been the subject of numerous articles about the prevention and treatment of CAC, but their clinical application is still relatively limited. Traditional Chinese Medicine (TCM) formulas are widely applied in clinical practice. TCM formulas have demonstrated great potential in the prevention and treatment of CAC in recent years, although there is still a lack of review. Our work aimed to summarize the effects and potential mechanisms of TCM formulas for the prevention and treatment of CAC, point out the issues and limitations of the current research, and provide recommendations for the advancement of CAC research in the future. We discovered that TCM formulas regulated many malignant biological processes, such as inflammation-mediated oxidative stress, apoptosis, tumor microenvironment, and intestinal microecology imbalance in CAC, through a review of the articles published in databases such as PubMed, SCOPUS, Web of Science, Embase, and CNKI. Several major signal transduction pathways, including NF-κB, STAT3, Wnt/β-catenin, HIF-1α, and Nrf2, were engaged. TCM formula may be a promising treatment candidate to control the colitis-cancer transformation, however further high-quality research is required.

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Dietary Goji Shapes the Gut Microbiota to Prevent the Liver Injury Induced by Acute Alcohol Intake

Cited by 20 publications

References 72 publications

Wolfberry enhanced the abundance of Akkermansia muciniphila by YAP1 in mice with acetaminophen‐induced liver injury

Wolfberry enhanced the abundance of Akkermansia muciniphila by YAP1 in mice with acetaminophen‐induced liver injury

Does diet or macronutrients intake drive the structure and function of gut microbiota?

Advances in research on the effectiveness and mechanism of Traditional Chinese Medicine formulas for colitis-associated colorectal cancer

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