Dietary glycine supplementation prevents heat stress-induced impairment of antioxidant status and intestinal barrier function in broilers

Effects of medical plants on alleviating the effects of heat stress on chickens

“…In hot and subtropical regions, the growth characteristics of farm animals are weakened due to significant fluctuations in biological processes, such as variations in nutritional compounds like protein, minerals, water, and energy metabolism. Numerous previous trails have informed that HS negatively impacts growth characteristics in poultry ( Song et al, 2018 ; Zhang et al, 2022 ; Abbas et al, 2022 ; AAbo Ghanima et al, 2023 ; Al-Garadi et al 2023 ; Deng et al, 2023 ; Kim and Lee, 2023 ; Zwirzitz et al, 2023 ). The reduction in growth performance of chickens during HS may be related to a reduction in feed consumption and body weight gain, as well as an increase in feed conversion ratio ( FCR ) ( Du et al, 2023 ; Kim and Lee, 2023 ; Sun et al, 2023 ).…”

“…Moreover, HS decreases feed efficiency, nutrients digestibility and its metabolism and absorption, thereby reducing nutrient availability to cells and physiological aspects ( Mashaly et al, 2004 ; Amedy et al, 2011; Bilal et al, 2021 ; Ringseis and Eder, 2022). As a result, the reduction of feed intake induced by HS may lead to a decrease in the energy provided for tissues building and impair biological functions in the cellular systems of the body ( Cheng et al, 2019 ; Chen et al 2023a ; Deng et al, 2023 ). Additionally, HS also causes intestinal dysfunction via distributing the intestinal structure, and decreasing the villus high, which play critical role in nutrients absorption ( Karl et al, 2017 ; Raya-Sandino et al, 2021 ; Yang et al, 2021 ; Gieryńska et al, 2022 ).…”

“…A key factor leading to the production of ROS is the final outcome of the respiratory chain, which occurs within the inner mitochondrial membrane. Here, the electron transport chain complexes within the mitochondria transfer electrons to oxygen ( Deng et al, 2023 ). The Nrf2-mediated antioxidant response pathway maintains cellular redox homeostasis by inducing the transcription of a variety of cytoprotective genes ( Lu et al, 2023 ).…”

“… Deng et al (2023) reported that the levels of OS indicators (such as MDA and H 2 O 2 ) were increased in serum under HS condition. Recently, multiple studies indicated that phytochemicals can alleviate OS in various syndrome and stress situations and reduce lipid peroxidation in the renal-hepatic tissues of heat-exposed broilers ( Ali et al, 2023 ).…”

Response of growth performance and cecum microbial communityto cyclic heat stress in broilers

“…Poultry gut health is vulnerable to HS. More and more research has proven that HS leads to impaired intestinal morphology (Goo et al, 2019), intestinal in ammatory response (Song et al, 2017), impaired tight junction structure (Zhang et al, 2017), and oxidative damage to the gut mucosa in poultry (Deng et al, 2023). The gut microbiota is susceptible to HS, and compared to the TN group, the quantity of bene cial bacteria (Lactobacillus and Bi dobacterium) surviving in the gut contents of broilers infected with HS remarkably decreased, while the quantity of Coliforms and Clostridia bacteria remarkably increased (Song et al, 2014).…”