Dietary glycine prevents chemical-induced experimental colitis in the rat

Tsune, Isao; Ikejima, Kenichi; Hirose, Miyoko; Yoshikawa, Mutsuko; Enomoto, Nobuyuki; Takei, Yoshiyuki; Sato, Nobuhiro

doi:10.1016/s0016-5085(03)01067-9

Cited by 128 publications

(113 citation statements)

References 53 publications

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“…As we know, Thr can be degraded to glycine (Dale, 1978;Edgar, 2005). Diet supplemented with 5% glycine prevented experimental colitis in rat models induced by an intracolonic injection of 2, 4, 6-trinitrobenzene sulfonic acid or oral administration of dextran sulfate sodium by abolishing increases in colonic expression of IL-1b and TNF-a, cytokine-induced neutrophil chemoattractant and macrophage inflammatory protein (Tsune et al, 2003). Collectively, our results indicated that higher Thr level could attenuate the deleterious inflammation effects after PRV infection, which could lower the risk of infection in mice testis, thus ensuring sperm quality.…”

Section: Discussionmentioning

confidence: 98%

Effect of threonine on immunity and reproductive performance of male mice infected with pseudorabies virus

Lin

Fang

et al. 2012

Animal

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The experiment was conducted to evaluate the effects of dietary threonine (Thr) supplement on reproductive performance and immune function of the male mice challenged with pseudorabies virus (PRV). Kun-Ming male mice were assigned randomly to four groups with different Thr levels (0.70%, 0.88%, 1.10% and 1.30%). Half of the mice in each group were injected with PRV or phosphate-buffered saline (PBS) after 5 weeks' adaptation to diets. The second experiment examined the effects of dietary Thr level on copulation rate, pregnancy rate and average number per litter of PRV-or PBS-challenged male mice that copulated with adult female mice on the 9th day post PRV challenge. Sperm quality and testosterone of mice were decreased after PRV infection, but this effect was attenuated by increasing Thr levels. Copulation and conception rates were increased with increasing Thr levels (P 5 0.14), but litter size was not affected (P . 0.05). In the PBS and PRV groups, mice fed higher levels of Thr had increased immunoglobulin (Ig)G, IgA and IgM concentrations. The PRV-specific antibody level, interleukin (IL)-1b and tumor necrosis factor (TNF)-a concentration in PRV groups enhanced with increasing Thr levels; however, there was no difference in PBS groups. Furthermore, higher toll-like receptor (TLR)2 and TLR9 expressions in testis were observed by PRV challenge compared with PBS groups, and higher Thr supplement attenuated PRV-challenged induced the upregulation effect of TLR2 and TLR9 mRNA expression in testis (P , 0.05). These data suggest that higher Thr consumption was recommended in order to counteract the deleterious effects of virus invasion, possibly through the downregulated expression of TLRs, and thus to improve immunity and reproduction performance of male mice challenged with PRV.

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Section: Discussionmentioning

confidence: 98%

Effect of threonine on immunity and reproductive performance of male mice infected with pseudorabies virus

Lin

Fang

et al. 2012

Animal

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“…These supportive effects are thought to be associated with improved bacterial flora, low antigenicity, and improved nutritional status [20,21]. Meanwhile, some reports have suggested that amino acids such as glutamine, glycine, and histamine have an anti-inflammatory effect on animal experimental and human chronic inflammatory disease [22][23][24][25][26]. Therefore, the abundant amino acids within ED might directly alleviate pancreatic inflammation and lead to pain relief.…”

Section: Discussionmentioning

confidence: 99%

Medical Management of Chronic Pancreatitis: What Can Physicians Do?

Lee¹

2017

Korean J Pancreas Biliary Tract

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Background & Aims. Chronic pancreatitis (CP) is often associated with abdominal pain, which impairs quality of life. The aim of this prospective study was to clarify whether the use of a low-fat elemental diet (ED) is beneficial for managing pain in patients with CP. Methods. Seventeen CP patients with pain despite fat-restricted dietary and conventional medical treatments were enrolled in this prospective study. These patients received low-fat ED therapy in addition to restricting fat intake for 8 weeks. The change of pain severity was examined by interviewing the patient and status of analgesic use. Results. Mean serum levels of amylase and lipase at 8 weeks after the beginning of low-fat ED therapy decreased compared to those before the therapy. At 8 weeks, pain alleviation after low-fat ED therapy was reported in 15 out of 17 patients (88%). Of these 15 patients, 10 patients reported complete pain disappearance. One of 3 patients with severe or moderate pain requiring analgesic was relieved of analgesic use after low-fat ED therapy. Conclusion. Low-fat ED therapy is useful as means of pain control in CP. The therapy is recommended in outpatients with CP who present with pain despite conventional dietary and medical treatments.

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“…33) In the intestine, glycine limits the damage caused by intestinal reperfusion injury, [34][35][36][37][38][39] abdominal irradiation 40) and can prevent or reduce the severity of experimentally induced colitis. 41) As in other tissues, the protection appears to be at least bi-modal. Tsune et al 41) demonstrated that dietary glycine was able to reduce intestinal inflammation in rats when given 2 d after administration of the damaging agent trinitrobenzenesulphonic acid (TNBS), whereas the work of Lee et al 37) showed a necessity for glycine administration before reperfusion to prevent ischemia/reperfusion injury.…”

Section: Introductionmentioning

confidence: 94%

“…41) As in other tissues, the protection appears to be at least bi-modal. Tsune et al 41) demonstrated that dietary glycine was able to reduce intestinal inflammation in rats when given 2 d after administration of the damaging agent trinitrobenzenesulphonic acid (TNBS), whereas the work of Lee et al 37) showed a necessity for glycine administration before reperfusion to prevent ischemia/reperfusion injury.…”

Section: Introductionmentioning

confidence: 94%

The Glycine Transporter GLYT1 in Human Intestine: Expression and Function

Howard

Hirst

2011

Biological & Pharmaceutical Bulletin

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Glycine is a well-documented cytoprotective agent and protects mammalian intestine against ischemiareperfusion injury, irradiation and experimentally induced colitis. The specific glycine transporter GLYT1 is found throughout the human intestine where it is responsible for some 30-50% of glycine uptake into intestinal epithelial cells across the basolateral membrane and appears to function to maintain glycine supply to enterocytes and colonocytes. This paper reviews current knowledge of GLYT1 and presents recent evidence supporting its essential role in glycine mediated cytoprotection in intestinal absorptive cells. Regulatory mechanisms involved in intestinal expression of GLYT1 are discussed and the potential of glycine for use as an anti-inflammatory, protective agent in the management of inflammatory bowel disease examined.

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Dietary glycine prevents chemical-induced experimental colitis in the rat

Cited by 128 publications

References 53 publications

Effect of threonine on immunity and reproductive performance of male mice infected with pseudorabies virus

Effect of threonine on immunity and reproductive performance of male mice infected with pseudorabies virus

Medical Management of Chronic Pancreatitis: What Can Physicians Do?

The Glycine Transporter GLYT1 in Human Intestine: Expression and Function

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