Dietary glycemic load and its association with glucose metabolism and lipid profile in young adults

Fernandes, A.C.O.; Marinho, Anabela; Lopes, Carla; Ramos, Elisabete

doi:10.1016/j.numecd.2021.10.001

Cited by 5 publications

(6 citation statements)

References 36 publications

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“…The results of previous studies indicate that a diet with a high glycemic load has no effect on glucose metabolism, which is in line with the present study. A diet with a high glycemic load, however, has a negative effect on the lipid profile, but this was not found in the present study (Fernandes et al, 2022). Ismawanti et al studied 56 type 2 diabetics, and their results indicated that an increase in blood glucose levels stimulates glycogen formation from glucose, fatty acid synthesis, and cholesterol levels from glucose, while high blood glucose levels can accelerate triglyceride formation.…”

Section: Discussioncontrasting

confidence: 77%

Section: Ta B L E 1 General Characteristics and Anthropometric Indica...contrasting

confidence: 71%

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The relationship of dietary inflammatory index and dietary patterns with premenstrual syndrome among women in Kermanshah: An analytical cross‐sectional study

Farpour

Soleimani

Moradinazar

et al. 2023

Food Science & Nutrition

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Premenstrual syndrome (PMS) is a common psychological condition that occurs continuously during the luteal phase of the menstrual cycle. Potential factors in this syndrome comprise the central nervous system, hormones, genetic background, and nutritional indicators. Little is known about foods or eating patterns that may be associated with this syndrome, yet nutritional factors can be considered in strategies for the management of PMS. The current study purposed to investigate the relationship between PMS and dietary inflammation index as well as PMS and food patterns. The present cross‐sectional study was conducted on 125 women and girls aged 20–46 years who experienced symptoms of PMS. The inclusion criteria included cooperation and consent to enter the study, a body mass index of 18.5–25 kg/m2, no underlying disease, no use of contraceptives or antidepressants, and no use of multivitamin or mineral supplements. In the first stage of this study, participants' height, weight, waist circumference, and hip circumference were measured. In the second stage, eating habits were examined using a semiquantitative Food Frequency Questionnaire. This study found a significant correlation between glycemic load quintiles as well as between energy and macronutrient intake and the dietary inflammatory index; however, it revealed a direct correlation between PMS and both Western‐mixed dietary and high‐salt–high‐sugar dietary patterns. Moreover, the Western food pattern was found to have a direct correlation with dietary inflammatory index, and the healthy food pattern had an inverse correlation with this index. This study showed that PMS symptoms are more severe with the consumption of high‐salt–high‐sugar or a Western‐mixed food dietary pattern. It seems that an imbalance in hormones and neurotransmitters can affect the metabolism of proteins, carbohydrates, and fats. Also, some foods, such as vegetables, and low‐fat and high‐fiber diets reduce plasma estrogen levels and the duration of PMS symptoms.

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Section: Discussioncontrasting

confidence: 77%

Section: Ta B L E 1 General Characteristics and Anthropometric Indica...contrasting

confidence: 71%

The relationship of dietary inflammatory index and dietary patterns with premenstrual syndrome among women in Kermanshah: An analytical cross‐sectional study

Farpour

Soleimani

Moradinazar

et al. 2023

Food Science & Nutrition

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“…16 However, both indices have limitations, such as variability in cutoff values and sensitivity to changes in lipid and glycemic profiles, warranting cautious interpretation in clinical settings. 17 Overall, the combined use of HOMA-IR and TyG index enhances the precision of IR evaluation. 18…”

Section: Discussionmentioning

confidence: 97%

Association of “Metabolic Dysfunction-Associated Steatotic Pancreas Disease” (MASPD) with Insulin Resistance

de Oliveira Andrade,

Matos de Oliveira,

Vinhaes Bittencourt

et al. 2024

Preprint

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Introduction: Metabolic Dysfunction Associated Steatotic Pancreas Disease (MASPD) is not yet a term or condition described in the medical literature. The MASPD is a relatively new and emerging condition that has garnered significant attention in the field of metabolic disorders. Objective: to investigate the association between MASPD and IR and explore the potential mechanisms that may contribute to this relationship. Materials and Methods: This cross/sectional study involved 157 participants diagnosed with MASPD based on ultrasonography criteria. Baseline demographic data were collected, including age, gender, and body mass index. Serum levels of fasting glucose, insulin, lipid profile (including total cholesterol, triglycerides, high/density lipoprotein cholesterol, and low/density lipoprotein cholesterol), glycated hemoglobin and insulin were measured using standardized laboratory techniques. Abdominal ultrasonography was performed on all participants using convex transducer (frequency range, 3,5 MHz) by experienced radiologist blinded to the clinical data. The association between MASPD and IR was assessed using logistic regression analysis, adjusting for potential confounders. Statistical significance was set at a p-value of less than 0.05. Results: The logistic regression analysis was performed to verify whether IR was a risk factor for MASPD. After adjusting for gender and age, the results demonstrate a significant correlation between MDASPD and markers of IR. TyG index: OR (95% IC) 5.72 (1.90 / 16.00), P 0.021, and HOMA IR: OR (95% IC) 6.20 (2.1 / 22.00) P 0.037. Conclusion: This study presents the first description of MDASPD and its association with IR indices. Our findings demonstrate a significant correlation between MDASPD and markers of IR. These results suggest that MDASPD may contribute to the development of insulin resistance and further highlight the importance of pancreatic health in metabolic disorders. Keywords: Metabolic Dysfunction, Pancreatic steatosis, MASPD, Insulin Resistance.

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“…All together these factors contribute to lower insulin sensitivity and to the development of dyslipidemia [10,43,44]. Though some controversial data have been published on the topic, several observational studies have supported these findings by identifying a direct association between dietary GL and glucose metabolism parameters [45][46][47][48][49][50][51][52]. Based on this, GI and GL have been extensively considered and validated as risk factors for chronic diseases [3][4][5][6][7][8][9].…”

Section: Discussionmentioning

confidence: 99%

Association of nutritional glycaemic indices with global DNA methylation patterns: results from the Moli-sani cohort

et al. 2022

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Background High dietary glycaemic index (GI) and load (GL) have been associated with increased risk of various cardiometabolic conditions. Among the molecular potential mechanisms underlying this relationship, DNA methylation has been studied, but a direct link between high GI and/or GL of diet and global DNA methylation levels has not been proved yet. We analyzed the associations between GI and GL and global DNA methylation patterns within an Italian population. Results Genomic DNA methylation (5mC) and hydroxymethylation (5hmC) levels were measured in 1080 buffy coat samples from participants of the Moli-sani study (mean(SD) = 54.9(11.5) years; 52% women) via ELISA. A 188-item Food Frequency Questionnaire was used to assess food intake and dietary GI and GL for each participant were calculated. Multiple linear regressions were used to investigate the associations between dietary GI and GL and global 5mC and 5hmC levels, as well as the proportion of effect explained by metabolic and inflammatory markers. We found negative associations of GI with both 5mC (β (SE) = − 0.073 (0.027), p = 0.007) and 5hmC (− 0.084 (0.030), p = 0.006), and of GL with 5mC (− 0.14 (0.060), p = 0.014). Circulating biomarkers did not explain the above-mentioned associations. Gender interaction analyses revealed a significant association of the gender-x-GL interaction with 5mC levels, with men showing an inverse association three times as negative as in women (interaction β (SE) = − 0.16 (0.06), p = 0.005). Conclusions Our findings suggest that global DNA methylation and hydroxymethylation patterns represent a biomarker of carbohydrate intake. Based on the differential association of GL with 5mC between men and women, further gender-based separate approaches are warranted.

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Dietary glycemic load and its association with glucose metabolism and lipid profile in young adults

Cited by 5 publications

References 36 publications

The relationship of dietary inflammatory index and dietary patterns with premenstrual syndrome among women in Kermanshah: An analytical cross‐sectional study

The relationship of dietary inflammatory index and dietary patterns with premenstrual syndrome among women in Kermanshah: An analytical cross‐sectional study

Association of “Metabolic Dysfunction-Associated Steatotic Pancreas Disease” (MASPD) with Insulin Resistance

Association of nutritional glycaemic indices with global DNA methylation patterns: results from the Moli-sani cohort

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