Dietary gluten triggers concomitant activation of CD4
            <sup>+</sup>
            and CD8
            <sup>+</sup>
            αβ T cells and γδ T cells in celiac disease

Han, Arnold; Newell, Evan W.; Glanville, Jacob; Fernandez‐Becker, Nielsen; Khosla, Chaitan; Chien, Yueh‐hsiu; Davis, Mark M.

doi:10.1073/pnas.1311861110

Cited by 181 publications

(173 citation statements)

References 57 publications

(61 reference statements)

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“…As a flip side of the potential benefit of the adjuvant properties of Vc9/Vd2 T cells, a dysregulated generation of APCs under the influence of Vc9/Vd2 T cells may eventually result in uncontrolled inflammation and the generation of cellular and humoral autoimmune responses, thereby contributing to the clinical symptoms in scenarios such as psoriasis [226], inflammatory bowel disease [227], celiac disease [196,228], and multiple sclerosis [229]. More research is clearly needed to delineate the complex interactions of Vc9/Vd2 T cells (and other unconventional T cells) with different immune and non-immune cells, both locally and systemically, and define how such knowledge can be exploited for therapeutic interventions to either boost protective immune responses or suppress excessive inflammation.…”

Section: Innate Regulation Of Adaptive Immune Responses: Vd2 + Versusmentioning

confidence: 99%

Human Vγ9/Vδ2 T cells: Innate adaptors of the immune system

Tyler

Doherty

Moser

et al. 2015

Cellular Immunology

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a b s t r a c tUnconventional T cells are gaining center stage as important effector and regulatory cells that orchestrate innate and adaptive immune responses. Human Vc9/Vd2 T cells are amongst the best understood unconventional T cells, as they are easily accessible in peripheral blood, can readily be expanded and manipulated in vitro, respond to microbial infections in vivo and can be exploited for novel tumor immunotherapies. We here review findings that suggest that Vc9/Vd2 T cells, and possibly other unconventional human T cells, play an important role in bridging innate and adaptive immunity by promoting the activation and differentiation of various types of antigen-presenting cells (APCs) and even turning into APCs themselves, and thereby pave the way for antigen-specific effector responses and long-term immunological memory. Although the direct physiological relevance for most of these mechanisms still needs to be demonstrated in vivo, these findings may have implications for novel therapies, diagnostic tests and vaccines.Ó 2015 Published by Elsevier Inc. Introduction cd T cells represent a third lineage of lymphocytes expressingre-arranged antigen receptors that co-evolved with 'classical' B cells and ab T cells over 400 million years, arguing for a crucial and non-redundant contribution of each lymphocyte to effective immune responses, and hence the evolutionary survival of all jawed vertebrate species [1]. 30 years have passed since the accidental and unexpected cloning of the cd T cell receptor (TCR) and the subsequent realization that ab T cells and cd T cells are fundamentally different with respect to the types of antigens they recognize and the distinct effector functions triggered upon such recognition. However, the manifold contributions of cd T cells to homeostasis, inflammation, infection and tumor surveillance have historically been neglected and are only beginning to be integrated into comprehensive models of the immune system [1][2][3][4][5][6][7].1. Innate-like pattern recognition by human Vc9/Vd2 T cells Like other 'unconventional' T cells carrying an ab TCR such as mucosal-associated invariant T (MAIT) cells and natural killer T (NKT) cells, cd T cells are characterized by a markedly restrictedTCR usage that allows them to recognize self and non-self molecules in the absence of classical antigen presentation via MHC I or MHC II. Vc9/Vd2 + cd T cells represent the major cd T cell subset in human peripheral blood where they typically comprise 1-5% in healthy adults [8]. In many microbial infections, Vc9/Vd2 T cells increase locally and/or systemically [9,10] and can reach in excess of 50% of all peripheral T cells within a matter of days [11], revealing a fundamental role of this unconventional T cell population in acute disease and suggesting their exploitation for diagnostic and therapeutic purposes [12][13][14]. Vc9/Vd2 T cells uniformly respond to a class of low molecular weight molecules often referred to as 'phosphoantigens' that represent metabolites of the isoprenoid biosynthesis...

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Section: Innate Regulation Of Adaptive Immune Responses: Vd2 + Versusmentioning

confidence: 99%

Human Vγ9/Vδ2 T cells: Innate adaptors of the immune system

Tyler

Doherty

Moser

et al. 2015

Cellular Immunology

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show abstract

“…In both conditions, the reaction to gluten is mediated by T-cell activation in the gastrointestinal mucosa (Han et al, 2013;Sapone et al, 2012). However, in wheat allergy, it is the cross-linking of immunoglobulin IgE by repeat sequences in gluten peptides that triggers the release of chemical mediators.…”

Section: Gliadins and The Celiac Diseasementioning

confidence: 99%

“…However, in wheat allergy, it is the cross-linking of immunoglobulin IgE by repeat sequences in gluten peptides that triggers the release of chemical mediators. Contrarily, the celiac disease is an autoimmune disorder as demonstrated by specific serologic autoantibodies [tTG and antiendomysium antibodies (EMA)] (Han et al, 2013). Besides these two conditions, there are cases of gluten reactions in which neither allergic nor autoimmune mechanisms are involved.…”

Section: Gliadins and The Celiac Diseasementioning

confidence: 99%

Gliadins in Foods and the Electronic Tongue

Veloso

Dias

Rodrigues

et al. 2016

Electronic Noses and Tongues in Food Science

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“…Community efforts to increase standardization of both experimental and analytical procedures improve the quality and reproducibility of omics data-as has been shown for microarray data 2 and the identification of proteinprotein interactions by mass spectrometry 3 , for example. In the immunology community in particular, multilaboratory collaborative projects, such as ImmGen (http://www.immgen.org/) and the Human Immunology Project Consortium (HIPC) (http://www.immuneprofiling.org), establish standardization of protocols and data annotations, while characterizing various aspects of the immune system at a high resolution and in different conditions [4][5][6][7] . In this Commentary, we lay out the advantages of a decentralized and integrative approach for interrogating high-dimensional (or 'largescale') immunology data and discuss some of the challenges the community faces in fully embracing such an approach.…”

Section: Divide and Conquermentioning

confidence: 99%