Dietary ginsenosides improve endothelium-dependent relaxation in the thoracic aorta of hypercholesterolemic rabbit

Kang, Soo Yeon; Kim, Soon Hoe; Schini, Valérie B.; Kim, Nak Doo

doi:10.1016/0306-3623(95)94002-x

Cited by 31 publications

(16 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[13][14][15] This injury leads to an alteration in the normal functionality of endothelium with a decrease in endothelium-dependent relaxation induced by acetylcholine. 16,17 It has been shown that the relationship between endothelial dysfunction and relaxation response induced by acetylcholine is similar. 18 In a study about the effect of cholesterol, Sanz et al have indicated that the degenerative effect of hypercholesterolemia on endothelial responses was similar with cholesterol levels.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of vascular smooth muscle and corpus cavernosum on hypercholesterolemia. Is resveratrol promising on erectile dysfunction?

et al. 2010

View full text Add to dashboard Cite

The aim of this study is to evaluate the effects of hypercholesterolemia in thoracic aorta (TA), mesenteric artery (MA), renal artery (RA), and corpus cavernosum (CC) isolated from cholesterolfed rabbits. For determination of the maximum detrimental effect, vasorelaxation and vasoconstriction results of arteries and CC have been compared. Animals were fed with a diet that contained 2% w/w cholesterol and 2% w/w high cholesterol plus resveratrol (4 mg kg -1 per day) for 6-week duration. Total cholesterol levels in the plasma were measured. Vascular and endothelial functions in RA, TA, MA, and CC were assessed by isolated tissue bath with cumulative doses of acetylcholine and sodium nitroprusside. The statistical significance of differences of groups was analyzed by means of one-way ANOVA or Student's t-test. P-values o0.05 were considered significant. There have been no significant changes on plasma total cholesterol levels between cholesterol and cholesterol þ resveratrol-treated groups. Vasorelaxation responses to acetylcholine in resveratroltreated group showed significant changes when compared with hypercholesterolemic group. No statistically significant differences were seen between non-receptor-mediated vasorelaxation responses between the three groups. Resveratrol might be an effective treatment in the prevention of atherosclerotic changes in arteries and CC. The initial effects of hypercholesterolemia on erectile dysfunction and endothelial dysfunction may be precluded with resveratrol. This protective effect may also ensure the prevention of coronary arterial diseases and renovascular diseases in hypercholesterolemic patients.

show abstract

Section: Discussionmentioning

confidence: 99%

Evaluation of vascular smooth muscle and corpus cavernosum on hypercholesterolemia. Is resveratrol promising on erectile dysfunction?

et al. 2010

View full text Add to dashboard Cite

show abstract

“…It has also been reported that crude saponin fractions of Korean red ginseng enhanced cerebral blood flow in rats (86) and ginsenosides reduced plasma cholesterol levels and the formation of atheroma in the aorta of rabbits fed on a high cholesterol diet (82). This antiatherosclerotic action of ginseng components is apparently due to the correction in the balance between prostacyclin and thromboxane (87), inhibition of 5-hydroxytryptamine (5-HT) release from, and adrenaline and thrombin-induced aggregation of platelets (88), regulation of cGMP and cAMP levels, and prolongation of the time interval between conversion of fibrinogen to fibrin (89).…”

Section: Cardiovascular Effects Of Ginsengmentioning

confidence: 93%

“…This relaxing effect of ginseng and its active constituents on the cardiovascular system is partially due to the release of endothelial NO. Researchers have reported that chronic feeding of rabbits with ginsenosides may enhance indirectly vasodilatation by preventing NO degradation by oxygen radicals such as superoxide anions (82). Ginsenosides have depressant action on cardiomyocyte contraction which may be mediated, in part, through increased NO production (83).…”

Section: Cardiovascular Effects Of Ginsengmentioning

confidence: 99%

Use of Ginseng in Medicine With Emphasis on Neurodegenerative Disorders

Gille²,

et al. 2006

View full text Add to dashboard Cite

Abstract. Ginseng, the root of Panax species, is a well-known herbal medicine. It has been used as a traditional medicine in China, Korea, and Japan for thousands of years and is now a popular and worldwide used natural medicine. The active ingredients of ginseng are ginsenosides which are also called ginseng saponins. Recently, there is increasing evidence in the literature on the pharmacological and physiological actions of ginseng. However, ginseng has been used primarily as a tonic to invigorate week bodies and help the restoration of homeostasis. Current in vivo and in vitro studies have shown its beneficial effects in a wide range of pathological conditions such as cardiovascular diseases, cancer, immune deficiency, and hepatotoxicity. Moreover, recent research has suggested that some of ginseng's active ingredients also exert beneficial effects on aging, central nervous system (CNS) disorders, and neurodegenerative diseases. In general, antioxidant, anti-inflammatory, anti-apoptotic, and immune-stimulatory activities are mostly underlying the possible ginseng-mediated protective mechanisms. Next to animal studies, data from neural cell cultures contribute to the understanding of these mechanisms that involve decreasing nitric oxide (NO), scavenging of free radicals, and counteracting excitotoxicity. In this review, we focus on recently reported medicinal effects of ginseng and summarize the current knowledge of its effects on CNS disorders and neurodegenerative diseases.

show abstract

“…It has previously been documented that bioactive components such as saponins (ginsenosides), antioxidants, peptides, polysaccharides, alkaloids, lignans and polyacetylenes are present in P. ginseng (Sticher, 1998;Palazon et al, 2003;Lu et al, 2009). Among these, the saponins (ginsenosides) are considered the principal bioactive ingredients (Palazon et al, 2003) and are believed to possess anti-fatigue and hepatoprotective physiological properties (Wu & Zhong, 1999), and improve cardiovascular system dysfunction (Kang et al, 1995). Likewise, numerous studies have demonstrated the pharmaceutical effects of P. ginseng on physical, chemical and biological stress (Takahashi et al, 1992;Shim et al, 2010), systemic immune function (Spelman et al, 2006) and glucose metabolism (Lim et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Effects of Korean ginseng (<i>Panax ginseng</i> C.A. Meyer) root extract on egg production performance and egg quality of laying hens

Yıldırım¹,

Şekeroğlu²,

Eleroğlu³

et al. 2013

SA J. An. Sci.

View full text Add to dashboard Cite

This study was conducted to determine the effect of Korean ginseng (Panax ginseng C.A. Meyer) root extract (PGRE) on egg production and egg quality characteristics of hens at the beginning of their laying period (20 weeks old). Four groups of commercial hens (Atak-S; Turkish native hybrid) were fed with diets containing 0 mg, 50 mg, 100 mg and 150 mg PGRE/kg. Experimental results indicated that dietary PGRE had no effect on feed intake, feed efficiency, egg mass (EM) or egg production parameters. Over 12 weeks, hen-day egg production (HDP) of the groups was 73.5%, 74.8%, 69.2% and 79.0%, respectively. The effect of different levels of PGRE on egg weight, shape index (SI), specific gravity, shell thickness, Haugh Unit (HU), yolk index (YI) and albumen index (AI) was not statistically significant during the entire experiment. Egg yolk colour was conspicuously lower in the 100 mg and 150 mg PGRE/kg groups than in the control. The L*, a* and b*, hue (H) and chroma (C*) values for eggshell colour were not significantly different among the groups, except for the colour difference (∆E*, (L 2 +a 2 +b 2 ) ½ ), where values in PGRE groups were higher than in the control group. The trolox equivalent antioxidant capacity (TEAC), ferric reducing antioxidant power (FRAP) and total phenolics concentration of PGRE were 598 ± 1.841 mmol trolox/kg, 15.45 ± 0.457 mmol TEAC/kg and 1.02 ± 0.03 g gallic acid equivalents (GAE)/kg, respectively. Serum glucose, cholesterol and triglyceride concentration were similar in the PGRE supplemented groups and the control. In conclusion, the dietary supplementation with PGRE did not affect the productivity performance traits and egg quality of hens at the beginning of the laying period.

show abstract

Dietary ginsenosides improve endothelium-dependent relaxation in the thoracic aorta of hypercholesterolemic rabbit

Cited by 31 publications

References 11 publications

Evaluation of vascular smooth muscle and corpus cavernosum on hypercholesterolemia. Is resveratrol promising on erectile dysfunction?

Evaluation of vascular smooth muscle and corpus cavernosum on hypercholesterolemia. Is resveratrol promising on erectile dysfunction?

Use of Ginseng in Medicine With Emphasis on Neurodegenerative Disorders

Effects of Korean ginseng (<i>Panax ginseng</i> C.A. Meyer) root extract on egg production performance and egg quality of laying hens

Contact Info

Product

Resources

About