Dietary fructose-induced gut dysbiosis promotes mouse hippocampal neuroinflammation: a benefit of short-chain fatty acids

Li, Jianmei; Rao, Yu; Zhang, Liping; Wen, Shiyu; Wang, Shui-Juan; Zhang, Xiaoyang; Xu, Qiang; Kong, Ling-Dong

doi:10.1186/s40168-019-0713-7

Cited by 172 publications

(149 citation statements)

References 59 publications

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“…Vegetable-based diets can increase SCFAs, accompanied by elevated Prevotella and some fiber-degrading Firmicutes [86]. When fed with fructose, Bacteroidetes was significantly decreased in the mice model, while Proteobacteria, Firmicutes, and pathogenic Helicobacteraceae were significantly increased [87].…”

Section: Food and Food-derived Metabolitesmentioning

confidence: 96%

The progress of gut microbiome research related to brain disorders

Zhu

Jiang

et al. 2020

J Neuroinflammation

276

192

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There is increasing evidence showing that the dynamic changes in the gut microbiota can alter brain physiology and behavior. Cognition was originally thought to be regulated only by the central nervous system. However, it is now becoming clear that many non-nervous system factors, including the gut-resident bacteria of the gastrointestinal tract, regulate and influence cognitive dysfunction as well as the process of neurodegeneration and cerebrovascular diseases. Extrinsic and intrinsic factors including dietary habits can regulate the composition of the microbiota. Microbes release metabolites and microbiota-derived molecules to further trigger host-derived cytokines and inflammation in the central nervous system, which contribute greatly to the pathogenesis of host brain disorders such as pain, depression, anxiety, autism, Alzheimer's diseases, Parkinson's disease, and stroke. Change of blood-brain barrier permeability, brain vascular physiology, and brain structure are among the most critical causes of the development of downstream neurological dysfunction. In this review, we will discuss the following parts: Overview of technical approaches used in gut microbiome studies Microbiota and immunity Gut microbiota and metabolites Microbiota-induced blood-brain barrier dysfunction Neuropsychiatric diseases ■ Stress and depression ■ Pain and migraine ■ Autism spectrum disorders Neurodegenerative diseases ■ Parkinson's disease ■ Alzheimer's disease ■ Amyotrophic lateral sclerosis ■ Multiple sclerosis

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Section: Food and Food-derived Metabolitesmentioning

confidence: 96%

The progress of gut microbiome research related to brain disorders

Zhu

Jiang

et al. 2020

J Neuroinflammation

276

192

View full text Add to dashboard Cite

show abstract

“…These studies have shown that upon modification of the microbial composition, there was a systemic and tissue specific reduction in insulin resistance [12,16], oxidative stress [12,15], blood lipids levels [12], liver damage [15,16], and in inflammatory markers [12,15]. In addition, a study on mice consuming a 30% fructose diet has described that antibiotic treatment suppressed the hippocampal neuroinflammatory response [17].…”

Section: Introductionmentioning

confidence: 99%

Antibiotic Treatment Does Not Ameliorate the Metabolic Changes in Rats Presenting Dysbiosis After Consuming a High Fructose Diet

et al. 2020

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High fructose consumption is one of the hallmarks of Western diets and has been found to induce MeS symptoms in parallel to gut microbial dysbiosis. However, the causality between those two is still elusive. Here, we studied whether a significant modification of gut microbial composition by antibiotics can influence the fructose-induced metabolic changes. Male Sprague-Dawley (SD) rats were divided into four groups including controls, controls + antibiotics, high fructose diet (HFrD, 60% fructose), HFrD + antibiotics (n = 7–8 in each group) for a period of 8-weeks. The high fructose diet increased blood pressure (BP), triglyceride (TG), fatty liver and the expression of hepatic genes related to lipogenesis, and fructose transport and metabolism. In addition, fructose changed the microbial composition and increased acetic and butyric acids in fecal samples but not in the blood. Antibiotic treatment significantly reduced microbial diversity and modified the microbial composition in the samples. However, minimal or no effect was seen in the metabolic phenotypes. In conclusion, high fructose consumption (60%) induced metabolic changes and dysbiosis in rats. However, antibiotic treatment did not reverse the metabolic phenotype. Therefore, the metabolic changes are probably independent of a specific microbiome profile.

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“…122 Supplementation with SCFAs activates NLRP6 and further restores the impaired gut mucosal barrier, thereby suppressing highfructose diet-triggered hippocampal neuroinflammation and neuronal deficiency. 123 These findings demonstrate the remarkable role of SCFAs in ameliorating CNS inflammation.…”

Section: Scfa-mediated Immunoregulation In Extraintestinal Diseasesmentioning

confidence: 82%

Demystifying the manipulation of host immunity, metabolism, and extraintestinal tumors by the gut microbiome

Zhang

Tang

Chen

et al. 2019

Sig Transduct Target Ther

172

143

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The trillions of microorganisms in the gut microbiome have attracted much attention recently owing to their sophisticated and widespread impacts on numerous aspects of host pathophysiology. Remarkable progress in large-scale sequencing and mass spectrometry has increased our understanding of the influence of the microbiome and/or its metabolites on the onset and progression of extraintestinal cancers and the efficacy of cancer immunotherapy. Given the plasticity in microbial composition and function, microbial-based therapeutic interventions, including dietary modulation, prebiotics, and probiotics, as well as fecal microbial transplantation, potentially permit the development of novel strategies for cancer therapy to improve clinical outcomes. Herein, we summarize the latest evidence on the involvement of the gut microbiome in host immunity and metabolism, the effects of the microbiome on extraintestinal cancers and the immune response, and strategies to modulate the gut microbiome, and we discuss ongoing studies and future areas of research that deserve focused research efforts.

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Dietary fructose-induced gut dysbiosis promotes mouse hippocampal neuroinflammation: a benefit of short-chain fatty acids

Cited by 172 publications

References 59 publications

The progress of gut microbiome research related to brain disorders

The progress of gut microbiome research related to brain disorders

Antibiotic Treatment Does Not Ameliorate the Metabolic Changes in Rats Presenting Dysbiosis After Consuming a High Fructose Diet

Demystifying the manipulation of host immunity, metabolism, and extraintestinal tumors by the gut microbiome

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