Dietary freshwater clam (<i>Corbicula fluminea</i>) extract suppresses accumulation of hepatic lipids and increases in serum cholesterol and aminotransferase activities induced by dietary chloretone in rats

Chijimatsu, Takeshi; Umeki, Miki; Kobayashi, Satoru; Kataoka, Yutaro; Yamada, Koji; Oda, Hiroaki; Mochizuki, Seibu

doi:10.1080/09168451.2015.1012147

Cited by 11 publications

(8 citation statements)

References 43 publications

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“…This efficiency of phytosterol encapsulation is comparable to phytosterol nanodispersion prepared by emulsification−evaporation 31 and to food protein-based phytosterol NPs. 32 Others have demonstrated that phytosterol-containing boiling-water extracts and lipid components of freshwater clams ameliorate hypercholesterolemia and alleviate dyslipidemia in tilapia 14,33 and rats 13,34 fed a high-fat diet.…”

Section: Resultsmentioning

confidence: 99%

Isolation and Characterization of Bioactive Proteoglycan–Lipid Nanoparticles from Freshwater Clam (Corbicula fluminea Muller) Soup

Gao

Wang

Zhou

et al. 2021

J. Agric. Food Chem.

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Nanoparticles can be prepared by several sophisticated processes but until now, it cannot be prepared by simple home cooking. Here, we report that two incidental food nanoparticles (iFNPs) consisting of proteoglycans and phytosterols were isolated from soup made from freshwater clam (Corbicula fluminea Muller), a renowned folk remedy for liver problems in China and other parts of East Asia. These two bioactive iFNPs were obtained and characterized by anionic exchange chromatography coupled with multi-angle laser light scattering measurement. Their hydrodynamic diameters and ζ-potentials were 50 ± 0.2 nm and −28.0 mV and 67 ± 0.4 nm and −9.96 mV, respectively. FT-IR revealed that the proteoglycans in the particles contained α-type heteropolysaccharides. Both iFNPs were resistant to pH changes and separation by mechanical force but responsive to temperature changes. They effectively inhibited cholesterol uptake in vitro, which resonates with the traditional belief that freshwater clam soup provides hepatoprotective benefits. This study suggests that these two proteoglycan–lipid iFNPs are the active moieties and offers a supramolecular structure-based approach to study the function of such complex matrices derived from food.

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Section: Resultsmentioning

confidence: 99%

Isolation and Characterization of Bioactive Proteoglycan–Lipid Nanoparticles from Freshwater Clam (Corbicula fluminea Muller) Soup

Gao

Wang

Zhou

et al. 2021

J. Agric. Food Chem.

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“…Stigmasterol act as an inhibitor of NF‐kB transcriptional activity. Oleic acid reduces NO and prostaglandin E 2 production by inhibiting NF‐kB signaling pathways . Thus, the hydrophobic compounds, especial phytosterols and fatty acid, may be the essential anti‐inflammatory components in FCE.…”

Section: Discussionmentioning

confidence: 99%

“…those from fish oil, sea cucumbers, and freshwater clams) as treatment options for a wide variety of disorders, including acute and chronic inflammation . Freshwater clam extract (FCE) products are becoming available in health food stores because of their therapeutic effects, particularly for providing hepatic protector functions and hypocholesterolemic effects . Although the traditional diet therapy of FCE has been used on liver diseases, its real mechanisms have not been well known.…”

Section: Introductionmentioning

confidence: 99%

Freshwater clam extract supplementation improves wound healing by decreasing the tumor necrosis factor α level in blood

et al. 2016

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“…The ratio of bone volume to total volume (BV/TV) of femur was determined by cone-beam X-ray mCT according to the method described by Ikegami et al (12). The mRNA levels of genes related to bone metabolism in the femur were determined by real-time PCR analysis according to the method described by Chijimatsu et al (18). The measured genes and their primer sequences that were used are shown in Table 2.…”

Section: Methodsmentioning

confidence: 99%

α-Tocopherol Intake Decreases Phylloquinone Concentration in Bone but Does Not Affect Bone Metabolism in Rats

Ikeda¹,

Nomura²,

Hanzawa³

et al. 2018

J Nutr Sci Vitaminol

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Previous studies have shown that a-tocopherol intake lowers phylloquinone (PK) concentration in some extrahepatic tissues in rats. The study's aim was to clarify the effect of a-tocopherol intake on vitamin K concentration in bone, as well as the physiological action of vitamin K. Male Wistar rats were divided into 4 groups. Over a 3-mo period, the K-free group was fed a vitamin K-free diet with 50 mg RRR-a-tocopherol/kg, the E-free group was fed a diet containing 0.75 mg PK/kg without vitamin E, the control group was fed a diet containing 0.75 mg PK/kg with 50 mg RRR-a-tocopherol/kg, and the E-excess group was fed a diet containing 0.75 mg PK/kg with 500 mg RRR-a-tocopherol/kg. PK concentration in the liver was higher in E-excess rats than in E-free rats, was lower in the tibias of control rats than in those of E-free rats, and was lower in E-excess rats than in control rats. Menaquinone-4 (MK-4) concentration in the liver was higher in E-excess rats than in E-free and control rats. However, MK-4 concentrations in the tibias of E-free, control, and E-excess rats were almost the same. Blood coagulation activity was lower in K-free rats than in the other rats but was not affected by the level of a-tocopherol intake. Additionally, dietary intake of PK and a-tocopherol did not affect uncarboxylated-osteocalcin concentration in the serum, femur density, or expression of the genes related to bone resorption and formation in the femur. These results suggest that a-tocopherol intake decreases PK concentration in bone but does not affect bone metabolism in rats.

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Dietary freshwater clam (Corbicula fluminea) extract suppresses accumulation of hepatic lipids and increases in serum cholesterol and aminotransferase activities induced by dietary chloretone in rats

Cited by 11 publications

References 43 publications

Isolation and Characterization of Bioactive Proteoglycan–Lipid Nanoparticles from Freshwater Clam (Corbicula fluminea Muller) Soup

Isolation and Characterization of Bioactive Proteoglycan–Lipid Nanoparticles from Freshwater Clam (Corbicula fluminea Muller) Soup

Freshwater clam extract supplementation improves wound healing by decreasing the tumor necrosis factor α level in blood

α-Tocopherol Intake Decreases Phylloquinone Concentration in Bone but Does Not Affect Bone Metabolism in Rats

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