Dietary food groups intake and cooking methods associations with pancreatic cancer: A case–control study

Ghorbani, Zeinab; Hekmatdoost, Azita; Eini-Zinab, Hassan; Farrokhzad, Solmaz; Rahimi, Roya; Malekzadeh, Reza; Pourshams, Akram

doi:10.1007/s12664-015-0573-4

Cited by 19 publications

(22 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, study done by Ghorbani Z et al [29] have shown in a well-matched case control study that increased frequency of intake of rice, bread and barbequed meat and deep fried vegetables can aggregate the risk while consumption of fish can decrease the incidence of pancreatic cancer. There has been no association between intake of fat and risk of pancreatic cancer [30] while exercise, which helps to maintain normal body weight, has been associated with a reduced risk of pancreatic cancer [31].…”

Section: Dietmentioning

confidence: 97%

Epidemiology of Pancreatic and Periampullary Cancer

Thapa

2015

Indian J Surg

View full text Add to dashboard Cite

Pancreatic cancer is an important public health problem, although infrequent but with an exceptionally high mortality rate worldwide. Given that the majority of cancers occur in association with smoking, diabetes, pancreatitis, genetic factors, and others and with a growing population worldwide in mind, more cases would be expected in the near future giving further impetus to investigating prevention and treatment strategies to this international issue. The representative data on epidemiology of carcinoma of pancreas in India and Nepal are very poor. While there are many questions to be resolved, it is apparent that many facets of pancreatic cancer are becoming increasingly understood, and prospects for prevention are becoming apparent. Hence, screening research, recommendations, and implementation is an obvious priority. Although previous studies have contributed to the knowledge of carcinoma of pancreas epidemiology, such association needs to be further verified with proper epidemiological work. A new and global approach to the study of carcinoma of pancreas epidemiology is required if the disease prevention and treatment strategies are to be adequately directed and supported in the coming years. The collection and analysis of epidemiologic carcinoma of pancreas data will play a critical role in guiding future disease prevention strategies and optimizing patient management.

show abstract

Section: Dietmentioning

confidence: 97%

Epidemiology of Pancreatic and Periampullary Cancer

Thapa

2015

Indian J Surg

View full text Add to dashboard Cite

show abstract

“…A meta-analysis conducted showing the relationship between red and processed meat consumption and increased risk of pancreatic cancer identified a significant association with red meat and increased risk of pancreatic cancer in men, and a significant positive association for processed meat [48]. Ghorbani et al [49], found a 67% increased risk of pancreatic cancer with an increased consumption of red meat, specifically barbecued. This is consistent with the findings in Jiao et al [50] stating that high cooking temperatures is related to increased amounts of N -(carboxymethyl)lysine (CML) advanced glycation end products (CML AGEs).…”

Section: Evidence Linking Dietary Intake To the Pathogenesis Of Pamentioning

confidence: 99%

“…This is consistent with the findings in Jiao et al [50] stating that high cooking temperatures is related to increased amounts of N -(carboxymethyl)lysine (CML) advanced glycation end products (CML AGEs). CML AGEs possibly contribute to insulin resistance, oxidative stress, and chronic inflammation [42,43,44,45,46,47,48,49,50,51,52,53]. Moreover, CML AGEs are speculated to contribute to the development of pancreatic cancer by changing the tissue stroma environment [50].…”

Section: Evidence Linking Dietary Intake To the Pathogenesis Of Pamentioning

confidence: 99%

“…This association between the consumption of red/processed meat and pancreatic cancer may also be explained by the mutagenic compounds produced during the cooking or preservation process [54]. Ghorbani et al [49] associated the increased risk of pancreatic cancer to high amounts of heterocyclic amines (HCAs) and polycyclic aromatic hyrdocarbons (PHA) produced from barbecuing. Heterocyclic amines are formed when meat is cooked at high temperatures.…”

Section: Evidence Linking Dietary Intake To the Pathogenesis Of Pamentioning

confidence: 99%

See 1 more Smart Citation

Nutrients and the Pancreas: An Epigenetic Perspective

Weisbeck

Jansen

2017

Nutrients

View full text Add to dashboard Cite

Pancreatic cancer is the fourth most common cause of cancer-related deaths with a dismal average five-year survival rate of six percent. Substitutional progress has been made in understanding how pancreatic cancer develops and progresses. Evidence is mounting which demonstrates that diet and nutrition are key factors in carcinogenesis. In particular, diets low in folate and high in fruits, vegetables, red/processed meat, and saturated fat have been identified as pancreatic cancer risk factors with a proposed mechanism involving epigenetic modifications or gene regulation. We review the current literature assessing the correlation between diet, epigenetics, and pancreatic cancer.

show abstract

“…Dietary habits represent a risk factor for the development of PDAC. Studies have already reported a statistically significant positive association between red-meat consumption in men and PDAC, and this evidence seems to rely especially on red, grilled, or processed meat [ 15 , 16 , 17 , 18 ]. Many molecular mechanisms have been proposed to explain this evidence.…”

Section: Introductionmentioning

confidence: 99%

Pancreatic Cancer and Obesity: Molecular Mechanisms of Cell Transformation and Chemoresistance

Cascetta

Cavaliere

Piro

et al. 2018

IJMS

View full text Add to dashboard Cite

Cancer and obesity are the two major epidemics of the 21st century. Pancreatic ductal adenocarcinoma (PDAC) is one of the leading causes of death, with a five-year overall survival rate of only 8%. Its incidence and mortality have increased in recent years, and this cancer type is expected to be among the top five leading causes of cancer-related death by 2030 in the United States (US). In the last three decades, the prevalence of overweight people has boosted with a consequent increase in obesity-related diseases. Considerable epidemiologic evidence correlates overweight and obese conditions to an increased risk of several types of cancer, including PDAC. Besides being a risk factor for multiple metabolic disorders, the tumor-promoting effects of obesity occur at the local level via inflammatory mediators that are associated with adipose inflammation and metabolic or hormones mediators and microbiota dysbiosis. Although an excess of body mass index (BMI) represents the second most modifiable risk factor for PDAC with an increased cancer related-death of more than 20–40%, still little is known about the molecular mechanisms that underlie this strong association. In this review, we focused on the role of obesity as a preventable risk factor of PDAC, discussing the molecular mechanisms linking obesity to cancer initiation and progression. Moreover, we highlighted the role of obesity in defining chemoresistance, showing how a high BMI can actually reduce response to chemotherapy.

show abstract

Dietary food groups intake and cooking methods associations with pancreatic cancer: A case–control study

Abstract: Our results indicate that increased frequency of intake of bread, rice, and red meat (especially barbecued) and deep fried vegetables can aggregate PC risk, while increased frequency of fish consumption can protect against PC. However, more studies are still needed.

Cited by 19 publications

References 40 publications

Epidemiology of Pancreatic and Periampullary Cancer

Epidemiology of Pancreatic and Periampullary Cancer

Nutrients and the Pancreas: An Epigenetic Perspective

Pancreatic Cancer and Obesity: Molecular Mechanisms of Cell Transformation and Chemoresistance

Contact Info

Product

Resources

About