Dietary folic acid supplementation improves semen quality and spermatogenesis through altering autophagy and histone methylation in the testis of aged broiler breeder roosters

Ye, Nanwei; Shi, Fangxiong; Huang, Zhiming; Cheng, Ying; Wei, Quanwei

doi:10.1016/j.theriogenology.2021.12.032

Cited by 12 publications

(13 citation statements)

References 57 publications

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“…Few studies focus on the relationship between folate and autophagy, especially on lipid metabolism in hepatocytes. Two studies on reproduction reported that dietary folate supplementation could improve rooster spermatogenesis and semen quality through autophagy in testis ( Ye et al, 2022 ), and autophagy could be involved in abnormal mouse placentation due to folate deficiency ( Yin et al, 2019 ). Another study found that folate supplementation could reduce LC3B expression in experimental NAFLD ( Youssry and Kamel, 2019 ).…”

Section: Discussionmentioning

confidence: 99%

Folate inhibits lipid deposition via the autophagy pathway in chicken hepatocytes

Du¹,

Pang²,

Wang³

et al. 2023

Poultry Science

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Section: Discussionmentioning

confidence: 99%

Folate inhibits lipid deposition via the autophagy pathway in chicken hepatocytes

Du¹,

Pang²,

Wang³

et al. 2023

Poultry Science

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“…Aging is known to be a factor contributing to male infertility, and folic acid supplementation increased semen volume, sperm concentration and sperm motility in older roosters. Additionally, it led to enhanced mRNA levels of important genes involved in spermatogenesis, including Cremτ [ 87 ]. Moreover, antioxidant supplementation in patients with idiopathic infertility resulted in the activation of proteins related to the CREM signaling pathway, such as protein kinase cAMP-dependent regulatory subunits ( PRKAR1A , PRKAR2A and PRKACA ) and lactate dehydrogenase C ( LDHC ) [ 88 ].…”

Section: Impact Of Xenobiotics In Cremτ Regulationmentioning

confidence: 99%

Novel Aspects of cAMP-Response Element Modulator (CREM) Role in Spermatogenesis and Male Fertility

Sánchez‐Jasso

López-Guzmán

Bermúdez‐Cruz

et al. 2023

IJMS

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Spermatogenesis is a very complex process with an intricate transcriptional regulation. The transition from the diploid to the haploid state requires the involvement of specialized genes in meiosis, among other specific functions for the formation of the spermatozoon. The transcription factor cAMP-response element modulator (CREM) is a key modulator that triggers the differentiation of the germ cell into the spermatozoon through the modification of gene expression. CREM has multiple repressor and activator isoforms whose expression is tissue-cell-type specific and tightly regulated by various factors at the transcriptional, post-transcriptional and post-translational level. The activator isoform CREMτ controls the expression of several relevant genes in post-meiotic stages of spermatogenesis. In addition, exposure to xenobiotics negatively affects CREMτ expression, which is linked to male infertility. On the other hand, antioxidants could have a positive effect on CREMτ expression and improve sperm parameters in idiopathically infertile men. Therefore, CREM expression could be used as a biomarker to detect and even counteract male infertility. This review examines the importance of CREM as a transcription factor for sperm production and its relevance in male fertility, infertility and the response to environmental xenobiotics that may affect CREMτ expression and the downstream regulation that alters male fertility. Also, some health disorders in which CREM expression is altered are discussed.

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“…For example, feeding folic acid (FA) could promote spermatogenesis in aged roosters. Furthermore, mechanistic studies have revealed that dietary FA supplementation is a potent anti-testicular aging agent that activates autophagy via modulation of mTOR signaling to delay testicular senescence ( 91 ). Autophagy gene changes have been widely observed in aging-related studies in other systems.…”

Section: Aging and Spermatogenesismentioning

confidence: 99%

Testicular aging, male fertility and beyond

Dong

Chen²,

Zhang³

et al. 2022

Front. Endocrinol.

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Normal spermatogenesis and sperm function are crucial for male fertility. The effects of healthy testicular aging and testicular premature aging on spermatogenesis, sperm function, and the spermatogenesis microenvironment cannot be ignored. Compared with younger men, the testis of older men tends to have disturbed spermatogenic processes, sperm abnormalities, sperm dysfunction, and impaired Sertoli and Leydig cells, which ultimately results in male infertility. Various exogenous and endogenous factors also contribute to pathological testicular premature aging, such as adverse environmental stressors and gene mutations. Mechanistically, Y-chromosomal microdeletions, increase in telomere length and oxidative stress, accumulation of DNA damage with decreased repair ability, alterations in epigenetic modifications, miRNA and lncRNA expression abnormalities, have been associated with impaired male fertility due to aging. In recent years, the key molecules and signaling pathways that regulate testicular aging and premature aging have been identified, thereby providing new strategies for diagnosis and treatment. This review provides a comprehensive overview of the underlying mechanisms of aging on spermatogenesis. Furthermore, potential rescue measures for reproductive aging have been discussed. Finally, the inadequacy of testicular aging research and future directions for research have been envisaged to aid in the diagnosis and treatment of testicular aging and premature aging.

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Dietary folic acid supplementation improves semen quality and spermatogenesis through altering autophagy and histone methylation in the testis of aged broiler breeder roosters

Cited by 12 publications

References 57 publications

Folate inhibits lipid deposition via the autophagy pathway in chicken hepatocytes

Folate inhibits lipid deposition via the autophagy pathway in chicken hepatocytes

Novel Aspects of cAMP-Response Element Modulator (CREM) Role in Spermatogenesis and Male Fertility

Testicular aging, male fertility and beyond

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