Dietary flaxseed oil reduces adipocyte size, adipose monocyte chemoattractant protein-1 levels and T-cell infiltration in obese, insulin-resistant rats

Baranowski, Maria; Enns, Jennifer; Blewett, Heather; Yakandawala, Uma; Zahradka, Peter; Taylor, Carla G.

doi:10.1016/j.cyto.2012.04.004

Cited by 57 publications

(37 citation statements)

References 63 publications

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“…Only a few RCTs and systematic reviews have investigated the effects of ALA supplementation with no reported effects on adiposity (267)(268)(269)(270). Similarly, animal studies suggest that ALA has no effect on body weight (271)(272)(273). However, most of these studies specifically measured body weight or whole body adiposity but not visceral adiposity.…”

Section: Obesity Reviewsmentioning

confidence: 99%

Functional foods as potential therapeutic options for metabolic syndrome

2015

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Obesity as part of metabolic syndrome is a major lifestyle disorder throughout the world. Current drug treatments for obesity produce small and usually unsustainable decreases in body weight with the risk of major adverse effects. Surgery has been the only treatment producing successful long-term weight loss. As a different but complementary approach, lifestyle modification including the use of functional foods could produce a reliable decrease in obesity with decreased comorbidities. Functional foods may include fruits such as berries, vegetables, fibre-enriched grains and beverages such as tea and coffee. Although health improvements continue to be reported for these functional foods in rodent studies, further evidence showing the translation of these results into humans is required. Thus, the concept that these fruits and vegetables will act as functional foods in humans to reduce obesity and thereby improve health remains intuitive and possible rather than proven.

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Section: Obesity Reviewsmentioning

confidence: 99%

Functional foods as potential therapeutic options for metabolic syndrome

2015

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“…Objectively, adiponectin has been reported to be both decreased [22] and increased [23] in Ob Zucker rats in comparison to their Le counterparts. In the latter case, it was suggested that the greater adipose mass of the Ob rats results in higher overall levels of adiponectin, despite lower concentrations of adiponectin produced by individual adipocytes [6,24]. Other authors have also hypothesized that increased adiponectin may be an adaptative response to the lack of leptin signaling [23].…”

Section: Regulatory Circulating Adipokinesmentioning

confidence: 99%

“…The regulation of body weight and serum lipids as well as the anti-inflammatory properties of various plant extracts and plant-derived bioactive components has been repeatedly reported using the Zucker rat model (Supporting Information Table 3, [4,6,24,[47][48][49][50][51][52]). Many of these studies showed beneficial effects specifically in the Ob Zucker rats and did not report or detect effects in their Le counterparts.…”

Section: Regulation Of Metabolic Parameters In Zucker Rats By Plant Ementioning

confidence: 99%

A rosemary extract enriched in carnosic acid improves circulating adipocytokines and modulates key metabolic sensors in lean Zucker rats: Critical and contrasting differences in the obese genotype

Romo‐Vaquero

Larrosa

Yáñez‐Gascón

et al. 2013

Molecular Nutrition Food Res

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“…Recent findings suggest that the size of adipocytes is a major modulator of their endocrine function. Hypertrophic adipocytes secrete greater amounts of TNF-α and MCH-1 than normal adipocytes, and this excess secretion has been hypothesized to cause insulin resistance (28 –30). In our studies, circulating levels of MCP-1 and TNF-α, as well as insulin were greatly elevated in mice fed on HFD for 15 weeks, indicating a proinflammatory state and insulin resistance seen in type-2 diabetes.…”

Section: Discussionmentioning

confidence: 99%

Ferulic acid lowers body weight and visceral fat accumulation via modulation of enzymatic, hormonal and inflammatory changes in a mouse model of high-fat diet-induced obesity

Melo

Lima

Carvalho

et al. 2017

Braz J Med Biol Res

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Previous studies have reported on the glucose and lipid-lowering effects of ferulic acid (FA) but its anti-obesity potential has not yet been firmly established. This study investigated the possible anti-obesitogenic effects of FA in mice fed a high-fat diet (HFD) for 15 weeks. To assess the antiobesity potential of FA, 32 male Swiss mice, weighing 20–25 g (n=6–8 per group) were fed a normal diet (ND) or HFD, treated orally or not with either FA (10 mg/kg) or sibutramine (10 mg/kg) for 15 weeks and at the end of this period, the body weights of animals, visceral fat accumulation, plasma levels of glucose and insulin hormone, amylase and lipase activities, the satiety hormones ghrelin and leptin, and tumor necrosis factor-α (TNF-α) and monocyte chemoattractant protein-1 (MCH-1) were analyzed. Results revealed that FA could effectively suppress the HFD-associated increase in visceral fat accumulation, adipocyte size and body weight gain, similar to sibutramine, the positive control. FA also significantly (P<0.05) decreased the HFD-induced elevations in serum lipid profiles, amylase and lipase activities, and the levels of blood glucose and insulin hormone. The markedly elevated leptin and decreased ghrelin levels seen in HFD-fed control mice were significantly (P<0.05) reversed by FA treatment, almost reaching the values seen in ND-fed mice. Furthermore, FA demonstrated significant (P<0.05) inhibition of serum levels of inflammatory mediators TNF-α, and MCH-1. These results suggest that FA could be beneficial in lowering the risk of HFD-induced obesity via modulation of enzymatic, hormonal and inflammatory responses.

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Dietary flaxseed oil reduces adipocyte size, adipose monocyte chemoattractant protein-1 levels and T-cell infiltration in obese, insulin-resistant rats

Cited by 57 publications

References 63 publications

Functional foods as potential therapeutic options for metabolic syndrome

Functional foods as potential therapeutic options for metabolic syndrome

A rosemary extract enriched in carnosic acid improves circulating adipocytokines and modulates key metabolic sensors in lean Zucker rats: Critical and contrasting differences in the obese genotype

Ferulic acid lowers body weight and visceral fat accumulation via modulation of enzymatic, hormonal and inflammatory changes in a mouse model of high-fat diet-induced obesity

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