Dietary flavonoids in cancer therapy and prevention: Substrates and inhibitors of cytochrome P450 CYP1 enzymes

Androutsopoulos, Vasilis P.; Papakyriakou, Athanasios; Vourloumis, Dionisios; Tsatsakis, Aristidis; Spandidos, Demetrios Α.

doi:10.1016/j.pharmthera.2010.01.009

Cited by 165 publications

(112 citation statements)

References 85 publications

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“…There are numerous mechanisms of antioxidant substances as anticancer such as: by scavenging free radical [7] , by inducing antioxidant enzymes [8] , by modulating protein kinase and lipid kinase signaling pathway [9] , by inhibiting cyclooxygenase-2 (COX-2) enzymatic activity [10] , by affecting phytoestrogenic [11] , by influencing nuclear transcription factor NF-κB [12] , by inducting phase I or phase II metabolizing enzymes [13] , inducting cell cycle arrest [14] , and by inhibiting matrix metalloproteinases (MMP)-2 and MMP-9 [15] .…”

Section: Commentsmentioning

confidence: 99%

Antioxidant and cytotoxic activity of Acanthus ilicifolius flower

Firdaus

Prihanto

Nurdiani

2013

Asian Pacific Journal of Tropical Biomedicine

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Section: Commentsmentioning

confidence: 99%

Antioxidant and cytotoxic activity of Acanthus ilicifolius flower

Firdaus

Prihanto

Nurdiani

2013

Asian Pacific Journal of Tropical Biomedicine

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“…They play an important role in protection of plants from microbial and insect attack. Many studies reported that flavonoids exhibit various effects as antioxidant (Siahpoosh et al, 2016;Balci & Özdemir, 2016), anti-cancer (Androutsopoulos et al, 2010;Ma et al, 2015), anti-allergic (Park et al, 2006), anti-thrombotic and vasodilatory (Rahimi et al, 2010), anticholinesterase (Ertas et al, 2016) actions. Finally, because of their UV-absorbing properties, flavonoids protect plants from the UV radiation of the sun and scavenge UV-generated reactive oxygen species (Shirley, 1996).…”

Section: Introductionmentioning

confidence: 99%

Simultaneous quantification of phenolic acids and flavonoids in Chamaerops humilis L. using LC–ESI-MS/MS

et al. 2018

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On this study, heated reflux extraction method has been used to identify the phenolic compounds from C. humilis var. argentea leaflets, rachis and fruits. Extractions were performed in both ultrapure water and 80% methanol solvents. The efficiency of procedures was determined in terms of the quality and quantity of phenolic acids and flavonoids identified. Chamaerops extracts have been characterized by high concentrations of phenolic compounds, which play a crucial role in protection against various diseases. LC-MS/MS was used to determine the chemical profile of various extracts obtained from Chamaerops. The results showed that the major components in leaflets and fruits extracts were quinic, malic and chlorogenic acids. On addition, nine minor acidic components were identified. Dn the other hand, rutin and hesperidin were found to be the major flavonoids. The methanol extract was shown as being the most efficient to identify phenolic compounds in C. humilis. Keywords: Chamaerops humilis L.; LC-ESO-MS/MS; phenolic compounds; chemical composition; extracts.Practical Application: Chamaerops humilis L. rich in flavonoids and phenolic acids was a great promising source of different bioactive components.

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“…Chemoprevention is a means of tumour control in which malignancy is prevented or reversed by nutritional or pharmacological intervention with natural or synthetic substances (57,58). Natural products have been utilized in cancer prevention because of their ability to induce apoptosis (59,60).…”

Section: Discussionmentioning

confidence: 99%

Ethanolic extract of Brazilian green propolis sensitizes prostate cancer cells to TRAIL-induced apoptosis

Szliszka

Zydowicz²,

Janoszka³

et al. 2011

Int J Oncol

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Abstract. Prostate cancer represents an ideal disease for chemopreventive intervention. Propolis possesses immunomodulatory, anti-tumour and chemopreventive properties. The tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) is an important endogenous anti-cancer agent that induces apoptosis selectively in tumour cells. However, some cancer cells are resistant to TRAIL-mediated apoptosis. Naturally occurring phenolic and polyphenolic compounds sensitize TRAIL-resistant cancer cells and augment the apoptotic activity of TRAIL. The ethanolic extract of Brazilian green propolis (EEP) is rich in phenolic components. Our in vitro results indicate the potential targets in the TRAILinduced apoptotic pathway for the cancer chemopreventive activity of Brazilian propolis. We examined the cytotoxic and apoptotic effects of Brazilian EEP and its bioactive components in combination with TRAIL on LNCaP prostate cancer cells. The chemical composition of Brazilian green propolis was determined by high performance liquid chromatographydiode array detection. The cytotoxicity was measured by 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl-tetrazolium and lactate dehydrogenase assays. Apoptosis was detected using annexin V-FITC by f low cytometry and f luorescence microscopy. The mitochondrial membrane potential (∆Ψm) was evaluated using DePsipher staining by fluorescence microscopy. Flow cytometry was used to analyse death receptor (TRAIL-R1 and TRAIL-R2) expression in LNCaP cells. The inhibition of nuclear factor-κB (NF-κB) (p65) activation in cancer cells was confirmed by the ELISA-based TransAM NF-κB kit. The LNCaP cells were shown to be resistant to TRAIL-induced apoptosis. Our study demonstrates that EEP sensitizes TRAIL-resistant prostate cancer cells. The main phenolic components detected in Brazilian green propolis are artepillin C, quercetin, kaempferol and p-coumaric acid. Brazilian propolis and its bioactive components markedly augmented TRAIL-mediated apoptosis and cytotoxicity in prostate cancer cells. Brazilian EEP enhanced the expression of TRAIL-R2 and the activity of NF-κB in LNCaP cells. The co-treatment of prostate cancer cells with 100 ng/ml TRAIL and 50 µg/ml EEP increased the percentage of apoptotic cells to 65.8±1.2% and caused a significant disruption of ∆Ψm in LNCaP cells. We show that Brazilian EEP helped cells overcome TRAIL resistance by engaging both intrinsic and extrinsic apoptotic pathways and regulating NF-κB activity.

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Dietary flavonoids in cancer therapy and prevention: Substrates and inhibitors of cytochrome P450 CYP1 enzymes

Cited by 165 publications

References 85 publications

Antioxidant and cytotoxic activity of Acanthus ilicifolius flower

Antioxidant and cytotoxic activity of Acanthus ilicifolius flower

Simultaneous quantification of phenolic acids and flavonoids in Chamaerops humilis L. using LC–ESI-MS/MS

Ethanolic extract of Brazilian green propolis sensitizes prostate cancer cells to TRAIL-induced apoptosis

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