Dietary flavonoids as cancer-preventive and therapeutic biofactors

Nishiumi, Shin; Miyamoto, Shingo; Kawabata, Kyuichi; Ohnishi, Kohta; Mukai, Rie; Murakami, Akira; Ashida, Hitoshi; Terao, Junji

doi:10.2741/229

Cited by 88 publications

(53 citation statements)

References 211 publications

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“…1,2) Although various chemical drugs have been developed, 3,4) frequent chemoresistance and side effects in patients with NSCLC require the development of new preventive and therapeutic agents. High intake of flavonoids from fruits and vegetables is associated with a low risk of various cancers, [5][6][7][8][9][10] including lung cancer. 11,12) Of these polyphenolic flavonoids, quercetin is readily found in fruits, vegetables, green and black tea, and various medical plants such as Euonymus alatus (Thunb.)…”

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Quercetin Potentiates Apoptosis by Inhibiting Nuclear Factor-kappaB Signaling in H460 Lung Cancer Cells

Youn

Jeong

et al. 2013

Biological & Pharmaceutical Bulletin

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The herbal flavonoid quercetin inhibits the growth of various cancer cells, but how it affects human cancer cells, particularly lung cancer cells, is unclear. We investigated the anticancer activity of quercetin and the underlying molecular mechanisms in non-small cell lung cancer (NSCLC) cells. Quercetin strongly inhibited cell proliferation, and increased sub-G1 and apoptotic cell populations regardless of p53 status. Quercetin-induced apoptosis was verified by caspase cleavage, Hoechst staining, trypan blue exclusion, and DNA fragmentation assays. Microarray analysis using H460 cells indicated that quercetin increased the expression of genes associated with death receptor signaling tumor necrosis factor-related apoptosis-inducing ligand receptor (TRAILR), caspase-10, interleukin (IL) 1R DNA fragmentation faotor 45 (DFF45), tumor necrosis factor receptor (TNFR) 1, FAS, inhibitor of kappaBalpha (IκBα)) and cell cycle inhibition growth arrest and DNA-damage inducible 45 (GADD45), p21 Cip1), but decreased the expression of genes involved in nuclear factor (NF)-kappaB activation (NF-κB, IKKα). Further validation assays confirmed that quercetin inhibited growth by suppressing NF-κB and by increasing the expression of death receptors and cell cycle inhibitors. Taken together, these findings suggest that quercetin may be useful in the prevention and therapy of NSCLC.Key words quercetin; lung cancer; apoptosis; death receptor; nuclear factor-kappaB pathway Lung cancer is the leading cause of cancer death in many developed countries because of its poor prognosis. Non-small cell lung cancer (NSCLC) accounts for 85% of lung cancer cases, of which 70% show advanced-stage disease at the time of diagnosis.1,2) Although various chemical drugs have been developed, 3,4) frequent chemoresistance and side effects in patients with NSCLC require the development of new preventive and therapeutic agents. High intake of flavonoids from fruits and vegetables is associated with a low risk of various cancers, 5-10) including lung cancer. 11,12) Of these polyphenolic flavonoids, quercetin is readily found in fruits, vegetables, green and black tea, and various medical plants such as Euonymus alatus (Thunb.) Sieb. Quercetin can act as either an antioxidant or a prooxidant depending on its concentration (1-40 µm or 40-100 µm, respectively). 13,14) Numerous studies have reported a broad range of pharmacological properties of quercetin, including benefits for inflammation, 15) atherosclerosis, 16) hypertension, 17) and neurodegeneration. 18,19) In addition to these beneficial effects, quercetin plays preventive and therapeutic roles in various types of cancer and cancer cells. [20][21][22][23][24][25] However, the anticancer effect of quercetin in NSCLC cells has been rarely addressed, and the underlying molecular mechanism remains to be determined.Here, we investigated the growth inhibitory role of quercetin in three NSCLC cell lines and found that its effect is p53-independent and triggered by apoptosis. Subsequent microarray analysis usin...

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Quercetin Potentiates Apoptosis by Inhibiting Nuclear Factor-kappaB Signaling in H460 Lung Cancer Cells

Youn

Jeong

et al. 2013

Biological & Pharmaceutical Bulletin

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“…Chrysantemum coronarium L., ідентифікованих методом ВЕРХ Відомо, що фенольні сполуки проявляють захисну роль в канцерогенезі, запаленні, атеросклерозі, тромбозі, а також мають високу антиоксидантну активність, антимікробні властивості (Nishiumi et al, 2011;Valdes et al, 2015). Згідно літературних джерел, рослини хризантеми овочевої характеризуються високим показником антиоксидатної активності та виявляють антимікробні властивості, що, можливо, пов'язано із вмістом фенольних сполук (Chuda, 1996;Lograda et al, 2013;Іvashchenko, 2017).…”

Section: таблиця 1 компонентний склад та кількісний вміст фенольних сunclassified

Phenolic Compounds Identified In Chrysantemum Coronarium L. Introduced In Ukrainian Polissya

Ivashchenko¹

2017

Agrobiodiversity for Improving Nutrition, Health and Life Quality

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The paper shows the results of chromatographic analysis of phenolic compounds extracted from a valuable vegetable, medicinal, decorative plant -garland chrysanthemum (Chrysantemum coronarium L.), introduced in Ukrainian Polissya. Introduction studies were carried out on experimental plots of Botanical Gardens of Zhytomyr National Agroecological University. Chrysantemum coronarium phenolic compounds were studied by high-performance liquid chromatography (HPLC) method. As a result of the research, 24 compounds of phenolic nature have been detected, from which 13 have been identified: chlorogenic acid, caffeic acid, cafeoylquinic acid, n-coumaroylquinic acid, 3-methylquercetin-7-bioside, 3-methylquercetin-3-bioside, rutin, luteolin-7-glycoside, isochlorogenic acid, apigenin-7-glucoside, luteolin, 3-methylquercetin, kaemferol. The analysis proves that the dominant components are isochlorogenic acid (35.48% amount of fenolic compounds), caffeic acid (10.25%), caffeoylquinic acid (17.18%) and luteolin-7-glycoside (7.85%). The amount of the detected phenolic compounds in air-dry raw material constitutes 2.18%. The research testifies to the fact that garland chrysanthemum contains an important group of biologically active substances (hydroxycinnamic acids and flavonoids) and is a promising plant for further study and application in the food and pharmaceutical industries.

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“…Flavonoid plays such diverse roles as protectants against UV radiation and pathogens in plants (Shirley 1996;Fini et al 2011). In addition, as human diet, it has health-promoting effects as potent antioxidant and anticancer agents (Cook and Samman 1996;Lotito and Frei 2006;Clere et al 2011;Cushnie and Lamb 2011;Nishiumi et al 2011;Russo et al 2012).…”

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confidence: 99%

Identification of a Novel DFR-A Mutant Allele Determining the Bulb Color Difference between Red and Yellow Onions (Allium cepa L.)

Kim¹,

Cho²,

Kim³

2017

Plant Breed. Biotech

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To introduce downy mildew resistance from a yellow-colored resistant cultivar, 'Santero', into a yellow breeding line, OT803, the F1 hybrid was produced by crossing Santero and OT803. The bulb color of the F1 hybrids became light pink, suggesting involvement of complementation between the DFR-A and ANS genes in the onion anthocyanin biosynthesis pathway. Since Santero contained active DFR-A and inactive ANS alleles, OT803 was assumed to harbor active ANS and inactive DFR-A alleles. However, some yellow-colored individuals of OT803 were shown to contain the homozygous genotype of the active DFR-A

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Dietary flavonoids as cancer-preventive and therapeutic biofactors

Cited by 88 publications

References 211 publications

Quercetin Potentiates Apoptosis by Inhibiting Nuclear Factor-kappaB Signaling in H460 Lung Cancer Cells

Quercetin Potentiates Apoptosis by Inhibiting Nuclear Factor-kappaB Signaling in H460 Lung Cancer Cells

Phenolic Compounds Identified In Chrysantemum Coronarium L. Introduced In Ukrainian Polissya

Identification of a Novel DFR-A Mutant Allele Determining the Bulb Color Difference between Red and Yellow Onions (Allium cepa L.)

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