Dietary flavonoids and iodine metabolism

Elst, J.P. Schröder-van der; Smit, Johannes W. A.; Romijn, Hans A.; Heide, D. van der

doi:10.1002/biof.5520190310

Cited by 19 publications

(10 citation statements)

References 16 publications

(20 reference statements)

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“…These include thyrotropin receptor (Santini et al 2003), iodine uptake by the sodium iodide transporter (Schröder van der Elst et al 2003), type 1 5′-deiodinase (Ferreira et al 2002), transthyretin (Kohrle et al 1988), thyroid hormone receptor (Moriyama et al 2002), and the thyroid hormone–dependent growth of pituitary cells (Ghisari and Bonefeld-Jorgensen 2005). Depression of serum T 4 and T 3 has been reported by several authors in PFOS-exposed rats (Lau et al 2003; Luebker et al 2005; Seacat et al 2003).…”

Section: Discussionmentioning

confidence: 99%

Association between Serum Perfluorooctanoic Acid (PFOA) and Thyroid Disease in the U.S. National Health and Nutrition Examination Survey

Melzer

Rice

Depledge

et al. 2010

Environ Health Perspect

430

291

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BackgroundPerfluorooctanoic acid (PFOA, also known as C8) and perfluorooctane sulfonate (PFOS) are stable compounds with many industrial and consumer uses. Their persistence in the environment plus toxicity in animal models has raised concern over low-level chronic exposure effects on human health.ObjectivesWe estimated associations between serum PFOA and PFOS concentrations and thyroid disease prevalence in representative samples of the U.S. general population.MethodsAnalyses of PFOA/PFOS versus disease status in the National Health and Nutrition Examination Survey (NHANES) for 1999–2000, 2003–2004, and 2005–2006 included 3,974 adults with measured concentrations for perfluorinated chemicals. Regression models were adjusted for age, sex, race/ethnicity, education, smoking status, body mass index, and alcohol intake.ResultsThe NHANES-weighted prevalence of reporting any thyroid disease was 16.18% (n = 292) in women and 3.06% (n = 69) in men; prevalence of current thyroid disease with related medication was 9.89% (n = 163) in women and 1.88% (n = 46) in men. In fully adjusted logistic models, women with PFOA ≥ 5.7 ng/mL [fourth (highest) population quartile] were more likely to report current treated thyroid disease [odds ratio (OR) = 2.24; 95% confidence interval (CI), 1.38–3.65; p = 0.002] compared with PFOA ≤ 4.0 ng/mL (quartiles 1 and 2); we found a near significant similar trend in men (OR = 2.12; 95% CI, 0.93–4.82; p = 0.073). For PFOS, in men we found a similar association for those with PFOS ≥ 36.8 ng/mL (quartile 4) versus ≤ 25.5 ng/mL (quartiles 1 and 2: OR for treated disease = 2.68; 95% CI, 1.03–6.98; p = 0.043); in women this association was not significant.ConclusionsHigher concentrations of serum PFOA and PFOS are associated with current thyroid disease in the U.S. general adult population. More work is needed to establish the mechanisms involved and to exclude confounding and pharmacokinetic explanations.

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Section: Discussionmentioning

confidence: 99%

Association between Serum Perfluorooctanoic Acid (PFOA) and Thyroid Disease in the U.S. National Health and Nutrition Examination Survey

Melzer

Rice

Depledge

et al. 2010

Environ Health Perspect

430

291

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“…Iodine uptake is not only an important step in thyroid hormone synthesis, but also a crucial exploitable mechanism for the treatment of differentiated (papillary and follicular) thyroid carcinoma with radioactive iodine. In this regard, among flavonoids thus far tested, myricetin would be an interesting modality for the treatment of thyroid carcinoma due to its capacity to increase iodide uptake and retention [67].…”

Section: Effects Of Phenolic Compounds On Thyroidmentioning

confidence: 99%

Impact of Antioxidant Natural Compounds on the Thyroid Gland and Implication of the Keap1/Nrf2 Signaling Pathway

Paunkov

Chartoumpekis

Ziros

et al. 2019

CPD

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Background: Natural compounds with potential antioxidant properties have been used in the form of food supplements or extracts with the intent to prevent or treat various diseases. Many of these compounds can activate the cytoprotective Nrf2 pathway. Besides, some of them are known to impact the thyroid gland, often with potential side-effects, but in other instances, with potential utility in the treatment of thyroid disorders. Objective: In view of recent data regarding the multiple roles of Nrf2 in the thyroid, this review summarizes the current bibliography on natural compounds that can have an effect on thyroid gland physiology and pathophysiology, and it discusses the potential implication of the Nrf2 system in the respective mechanisms. Method & Results: Literature searches for articles from 1950 to 2018 were performed in PubMed and Google Scholar using relevant keywords about phytochemicals, Nrf2 and thyroid. Natural substances were categorized into phenolic compounds, sulfur-containing compounds, quinones, terpenoids, or under the general category of plant extracts. For individual compounds in each category, respective data were summarized, as derived from in vitro (cell lines), preclinical (animal models) and clinical studies. The main emerging themes were as follows: phenolic compounds often showed potential to affect the production of thyroid hormones; sulfur-containing compounds impacted the pathogenesis of goiter and the proliferation of thyroid cancer cells; while quinones and terpenoids modified Nrf2 signaling in thyroid cell lines. Conclusion: Natural compounds that modify the activity of the Nrf2 pathway should be evaluated carefully, not only for their potential to be used as therapeutic agents for thyroid disorders, but also for their thyroidal safety when used for the prevention and treatment of non-thyroidal diseases.

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“…NIS half-life is approximately 5 days in the presence and approximately 3 days in the absence of TSH [5]. Schröder-van der Elst et al [20] showed that the inhibitory effect on iodide influx exerted by some flavonoids (kaempferol, apigenin, luteolin) is a consequence of decreased NIS mRNA expression. The XN-triggered up-regulation of iodide influx reported in this experiment cannot be explained in the same way.…”

Section: Discussionmentioning

confidence: 98%

“…Schröder-van der Elst et al [20] reported that most flavonoids decrease, whereas myricetin increases iodide uptake by 35% after 4 days of incubation at 5 lM using the human follicular thyroid cancer cell line (FTC133), which was stably transfected with the human NIS. We observed significant increase of iodide uptake in the nontransformed rat FRTL-5 cell line which was maximal after 2 and 3 days of incubation using a much lower concentration of XN (1 nM).…”

Section: Discussionmentioning

confidence: 99%

Xanthohumol stimulates iodide uptake in rat thyroid-derived FRTL-5 cells

Radović

Schmutzler

Köhrle

2005

Mol. Nutr. Food Res.

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Sodium-iodide-symporter (NIS), an integral plasma membrane glycoprotein, mediates the sodium-dependent active uptake of iodide (I(-)) into the thyroid gland, which is a fundamental step in thyroid hormone synthesis. In this work, we analyzed the influence of xanthohumol (XN), a prenylated chalcone from hops (Humulus lupulus L.), on the I(-) uptake in a cell culture model of normal, nontransformed rat thyrocytes (FRTL-5). Acute treatment with nanomolar concentrations of XN does not influence I(-) uptake, but after 2 and 3-days of XN stimulation an increase in I(-) uptake was observed; I(-) uptake was maximally increased by 50% compared to control after 3-days of XN stimulation at 1 nM. A clear time-dependent stimulation was observed which showed no marked concentration relationship, however. To investigate whether expression of NIS mRNA is also increased, we grew FRTL-5 cells for 3-days in a medium containing increasing concentrations of XN (0.1 nM-1 muM). Northern blot analysis showed no difference in NIS mRNA transcript levels between control cells and those treated with different concentrations of XN. This study revealed that nanomolar concentrations of XN, a unique compound with anticancer properties, exert stimulating effects on radioiodide uptake. In contrast to many other plant-derived phenolic secondary metabolites such as (iso-)flavonoids, which inhibit I(-) uptake, XN might be an interesting candidate for more efficient radioiodide therapy of thyroid and perhaps other cancer expressing NIS such as breast cancer.

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Dietary flavonoids and iodine metabolism

Cited by 19 publications

References 16 publications

Association between Serum Perfluorooctanoic Acid (PFOA) and Thyroid Disease in the U.S. National Health and Nutrition Examination Survey

Association between Serum Perfluorooctanoic Acid (PFOA) and Thyroid Disease in the U.S. National Health and Nutrition Examination Survey

Impact of Antioxidant Natural Compounds on the Thyroid Gland and Implication of the Keap1/Nrf2 Signaling Pathway

Xanthohumol stimulates iodide uptake in rat thyroid-derived FRTL-5 cells

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