Dietary flavonoid derivatives enhance chemotherapeutic effect by inhibiting the DNA damage response pathway

Investigation of antitumor properties of semi-synthetic flavonoid derivatives on gynecological cancer cell lines

“…showing that protoapigenone and its derivatives caused DNA damage and cell death induction in the breast, prostate, and lung cancer cells [127,134,148]. In this regard, Kuo et al (2016) reported that dietary Fls could inhibit Chk1 phosphorylation and impair DNA repair pathways to increase breast cancer sensitivity to cisplatin treatment [149]. Similarly, our results were consistent with Wang et al (2012) observing that PrFl derivatives (WYC0209 and WYC02) decreased the cisplatin-induced Chk1 phosphorylation in MDA-MB-231 breast cancer cells [110].…”

Xanthohumol, a Prenylated Flavonoid from Hops, Induces Caspase-Dependent Degradation of Oncoprotein BCR-ABL in K562 Cells

“…In this regard, XN could enhance the therapeutic efficacy of imatinib via alleviating imatinib-induced autophagy; on the other hand, XN itself could also eliminate oncoprotein BCR-ABL and induce apoptosis, suggesting XN, at least, could serve as an imatinib sensitizer and an oncoprotein degrader in the treatment of CML. Previous study have suggested flavonoids and its derivatives could be served as candidates of chemosensitizer, and this chemosensitizing function might be through inhibiting NF-κB, P-glycoproteins, ATR/ATM signaling, AKT, and increasing the expression of p53 protein [44,45]. For the first time, we found a novel mechanism by which XN enhanced K562 cells sensitivity to imatinib was related to autophagy inhibition and BCR-ABL degradation.…”

Effects of the Ser326Cys Polymorphism in the DNA Repair OGG1 Gene on Cancer, Cardiovascular, and All-Cause Mortality in the PREDIMED Study: Modulation by Diet

“…The MedDiet is characterized by a high intake of vegetables 37,65 . Vegetables are very rich in antioxidants and other phytochemicals 66,67 that may contribute to a better DNA protection from oxidation in Cys326Cys individuals who have less capacity for repairing it [68][69][70] . Recent metaanalyses 71,72 have shown that high vegetable consumption is associated with a lower risk of allcause mortality 71,72 , particularly cardiovascular mortality 72 .…”