Dietary fish protein lowers blood pressure and alters tissue polyunsaturated fatty acid composition in spontaneously hypertensive rats

Ait-Yahia, Dalila; Madani, Sihem; Savelli, Jean-Luc; Prost, Josiane; Bouchenak, Malika; Belleville, J.

doi:10.1016/s0899-9007(02)00858-4

Cited by 55 publications

(37 citation statements)

References 27 publications

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“…Consistent with several other reports (20,21), this study showed that dietary consumption, such as fish intake, had effects on fasting FFA composition. This offers evidence for improving abnormal FFA composition through dietary intervention in EH patients.…”

Section: Impact Factors Of Fasting Serum Ffa Composition In Eh Patientssupporting

confidence: 92%

Fasting Serum Free Fatty Acid Composition, Waist/Hip Ratio and Insulin Activity in Essential Hypertensive Patients

Wang

Song³

et al. 2008

Hypertens Res

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Abnormal fatty acid metabolism may play an important role in the pathogenesis of essential hypertension (EH). We compared fasting serum free fatty acid (FFA) composition between EH patients and nonhypertensive (NH) subjects, and examined the relationships between fasting serum FFA composition and waist/hip ratio, insulin activity, blood pressure, serum zinc, age, and sex in both groups. We conducted a cross-sectional study of 232 community-dwelling subjects aged between 35 and 60 years: 109 EH patients and 123 NH subjects. Serum FFA was determined by HPLC analysis. The data were analyzed by multivariate linear stepwise regression, stratified analysis, and correlation analysis. In men, EH patients had lower C22:6/C20:5 ratios (n -3 6-desaturase activity index, 7.96±8.81 vs . 14.5±13.1, p < 0.01), polyunsaturated fatty acid (PUFA), n -3 PUFA and polyunsaturated/saturated (P/S) ratios compared with male subjects without hypertension. There were no differences in women. Fasting serum FFA composition was significantly related to many variables, including waist/hip ratio, insulin sensitivity index, and serum zinc (all p < 0.05 or < 0.01) for all the subjects, and included both age-and sex-related differences (both p < 0.05). Compared with NH, EH patients had lower levels of serum zinc (14.9 ± 5.00 µmol L -1 vs . 16.8 ± 6.38 µmol L -1 , p < 0.05). We concluded that EH patients had marked alteration in fasting serum FFA composition, which was affected by upper body obesity, insulin resistance, zinc deficiency, and high dietary fat, and that the differences were age-and sex-

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Section: Impact Factors Of Fasting Serum Ffa Composition In Eh Patientssupporting

confidence: 92%

Fasting Serum Free Fatty Acid Composition, Waist/Hip Ratio and Insulin Activity in Essential Hypertensive Patients

Wang

Song³

et al. 2008

Hypertens Res

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“…Fax: +81-95-813-5216; E-mail: tanaka@sun.ac.jp Abbreviations: ACE, angiotensin I-converting enzyme; CPT, carnitine palmitoyltransferase; FAS, fatty acid synthase; G6PDH, glucose-6-phosphate dehydrogenase; HDL, high density lipoprotein; LETO, Long-Evans Tokushima Otsuka; OLETF, Otsuka Long-Evans Tokushima Fatty; PAP, phosphatidate phosphohydrolase; SD, Sprague-Dawley; SH, spontaneously hypertensive of hypertension and diabetes. [20][21][22] Hence, the fractions other than lipids, mainly the protein fraction, in seafood might play an important role in human health. Wergedahl et al 23) reported that fish protein hydrolysate exhibits the hypocholesterolemic effects.…”

mentioning

confidence: 99%

Effects of Dietary Oyster Extract on Lipid Metabolism, Blood Pressure, and Blood Glucose in SD Rats, Hypertensive Rats, and Diabetic Rats

Tanaka

Nishizono

Kugino

et al. 2006

Bioscience, Biotechnology, and Biochemistry

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“…There are only a few reports regarding the effect of animal proteins [45], including marine proteins [46][47][48] on lipid metabolism as compared to soy protein or casein. Animal proteins including beef, pork, and turkey meat did not differ from casein in their effects on cholesterol metabolism [45].…”

Section: Fish Proteinmentioning

confidence: 99%

“…Furthermore, hypocholesterolemic effects of fish proteins have been reported [48,51,52]. The main active components of fish proteins in its hypocholesterolemic effects were considered to be fish peptides formed by digestion [52]; however, the mechanism has not yet been elucidated.…”

Section: Fish Proteinmentioning

confidence: 99%

Role of Marine Foods in Prevention of Obesity

Nakajima

2010

Handbook of Seafood Quality, Safety and Health Applications

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Dietary fish protein lowers blood pressure and alters tissue polyunsaturated fatty acid composition in spontaneously hypertensive rats

Cited by 55 publications

References 27 publications

Fasting Serum Free Fatty Acid Composition, Waist/Hip Ratio and Insulin Activity in Essential Hypertensive Patients

Fasting Serum Free Fatty Acid Composition, Waist/Hip Ratio and Insulin Activity in Essential Hypertensive Patients

Effects of Dietary Oyster Extract on Lipid Metabolism, Blood Pressure, and Blood Glucose in SD Rats, Hypertensive Rats, and Diabetic Rats

Role of Marine Foods in Prevention of Obesity

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