Dietary Fish Oil Reduces Microvascular Thrombosis in a Porcine Experimental Model

Thorwest, Martin; Balling, Eva; Kristensen, Steen Dalby; Aagaard, Susanne; Hakami, Ardeshir; Husted, Søren; Marqversen, J.; Hjortdal, Vibeke E.

doi:10.1016/s0049-3848(00)00233-4

Cited by 15 publications

(8 citation statements)

References 13 publications

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“…Multiple studies have emphasized different antiplatelet effects of cocoa, [49][50] its flavonol constituents, 51,52 and specifically dark chocolate. [53][54][55][56] Similarly, antiplatelet activity for omega-3 is recognized, [57][58][59] with reduced microvascular thromboses demonstrated in a porcine model, 60 although it is not clear whether this usually translates to clinically relevant hemorrhagic risk. 61,62 In the current study, items containing fish oil and omega-3 were reported as worsening epistaxis by 15 HHT patients.…”

Section: Discussionmentioning

confidence: 99%

Lifestyle and Dietary Influences on Nosebleed Severity in Hereditary Hemorrhagic Telangiectasia

et al. 2013

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ObjectiveTo identify factors influencing the severity of epistaxis in hereditary haemorrhagic telangiectasia. Study designParticipants with and without hereditary haemorrhagic telangiectasia were recruited from a specialist UK service, and online following advertisement by the HHT Foundation International. Both groups were asked to complete a non-biased questionnaire. MethodsThe reported effects of specific treatments or lifestyle factors on epistaxis were assigned positive values if beneficial, negative values if detrimental, zero if "no difference," and summed to enable statistical analysis. ResultsEpistaxis affected 649/666 (97%) participants with hereditary haemorrhagic telangiectasia and was significantly more frequent than in control participants. Specialist invasive treatments were reported as beneficial, laser therapy more frequently than cauterisation. Medical treatments commonly used for HHT epistaxis (female hormones, anti-oestrogens, tranexamic acid, aminocaproic acid, nasal creams and bevacizumab) also had significantly positive (beneficial) scores. Lifestyle and dietary factors were generally detrimental, but room humidification, nasal lubrication and saline treatments were all reported as beneficial (95% confidence intervals greater than zero). Multiple food items were volunteered as being detrimental to epistaxis. The most frequently reported items were alcohol (n=45; 6.8% of participants) and spices (n=26, 3.9% of participants). Remaining foods 4 reported to exacerbate epistaxis were also found to be high in salicylates (including red wine, spices, chocolate, coffee and certain fruits), natural antiplatelet activity (garlic, ginger, ginseng, gingko biloba and vitamin E15) or in omega-3 acids (oily fish, salmon). ConclusionThis study supports existing treatments and suggests lifestyle and dietary manoeuvres that may also improve nosebleeds in hereditary haemorrhagic telangiectasia.

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Section: Discussionmentioning

confidence: 99%

Lifestyle and Dietary Influences on Nosebleed Severity in Hereditary Hemorrhagic Telangiectasia

et al. 2013

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“…46,47 Such changes have been attributed to a reduced decrease of thromboxane A 2 and an increase of the nonaggregating thromboxane A 3 . 48…”

Section: N-3 and Platelet Functionmentioning

confidence: 99%

Nutrition, Supplements, and Vitamins in Platelet Function and Bleeding

2010

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“…Dietary fish oil improved the microcirculation secondary to an ischemic insult in an experimental rat model (16). We recently reported that n-3 PUFA decreased microvascular thrombosis after ischemia-reperfusion injury in a porcine experimental model (17). Finally, cod liver oil has been shown to reduce platelet deposition and injury-related vasoconstriction in pigs (18).…”

Section: Experimental Studiesmentioning

confidence: 98%

n−3 polyunsaturated fatty acids and coronary thrombosis

Kristensen

Iversen

Schmidt³

2001

Lipids

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Studies of Greenland Eskimos showed that a very high intake of marine n-3 fatty acids markedly inhibited platelet reactivity and suggested that intake of these fatty acids might prevent coronary thrombosis. Later studies with lower, more practical doses of n-3 fatty acids also have shown a platelet inhibitory effect of n-3 fatty acids, albeit fairly marginal. Furthermore, n-3 fatty acids have little effect on measures of blood coagulability and may slightly decrease fibrinolysis. In animal models, n-3 fatty acids often have been shown to inhibit thrombosis, but again the doses have tended to be very high. Finally, there has been little effect of (low-dose) n-3 fatty acids in clinical trials in humans on the incidence of myocardial infarction. Overall, there is little evidence for a major antithrombotic effect of practical doses of n-3 fatty acids on coronary thrombosis. This does not exclude a beneficial effect of n-3 fatty acids on coronary heart disease as suggested from clinical trials, but the major effect may be antiarrhythmic rather than antithrombotic.

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Dietary Fish Oil Reduces Microvascular Thrombosis in a Porcine Experimental Model

Cited by 15 publications

References 13 publications

Lifestyle and Dietary Influences on Nosebleed Severity in Hereditary Hemorrhagic Telangiectasia

Lifestyle and Dietary Influences on Nosebleed Severity in Hereditary Hemorrhagic Telangiectasia

Nutrition, Supplements, and Vitamins in Platelet Function and Bleeding

n−3 polyunsaturated fatty acids and coronary thrombosis

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