Dietary fish oil does not influence acute rejection rate and graft survival after renal transplantation: a randomized placebo-controlled study

Hernández, Domingo; Guerra, R Castaño; Milena, Antonio; Torres, Armando; García, Sagrario; García, Cristina Moya; Abreu, Pedro; González, Antonieta; Gómez, María Ángeles Ruiz; Rufino, Margarita; González-Posada, José Manuel; Lorenzo, V.; Salido, Eduardo

doi:10.1093/ndt/17.5.897

Cited by 24 publications

(15 citation statements)

References 41 publications

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“…Some trials found a benefit of fish oil supplementation on renal function (15,17,19,24). This suggests that fish oil could possibly benefit a subset of patients.…”

Section: Discussionmentioning

confidence: 99%

“…A total of 10 RCT, with 291 patients in the fish oil group and 312 patients in the placebo or control group, described graft survival among kidney transplant recipients (Table 2) (9,(15)(16)(17)(18)(19). However, most studies did not perform quantitative analysis of graft survival, underscoring the excellent overall results in kidney transplantation irrespective of fish oil supplementation.…”

Section: Graft-related Outcomesmentioning

confidence: 99%

“…Each study is shown by a risk ratio (RR) estimate along with whiskers corresponding to its 95% confidence interval (CI). RCT (with a total of 200 and 199 patients in the fish oil and control groups, respectively) included triglycerides as an outcome (9,14,15,(17)(18)(19)22,23,25,26). Although there were exceptions, in aggregate, the data support a benefit of fish oil in lowering serum triglyceride concentrations.…”

Section: Cardiovascular Disease-related Outcomesmentioning

confidence: 99%

“…Figure 4 depicts the net difference in GFR and 95% CI across studies in kidney transplant recipients (8,13,(15)(16)(17)20,21,24,27,28). Higher values suggest better renal function in those who received fish oil.…”

Section: Effects Of Fish Oil Supplementation In Subsets Of Patientsmentioning

confidence: 99%

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Effects of Fish Oil Supplementation on Kidney Transplantation

Tatsioni

Chung

Sun

et al. 2005

Journal of the American Society of Nephrology

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The objective of this study was to assess the effects of omega-3 fatty acid supplementation on various kidney transplantrelated outcomes. A systematic review and meta-analysis was performed of published randomized, controlled trials (RCT). There were 16 kidney transplant RCT with a total of 812 patients. All trials evaluated fish oil with dosages that ranged from 1.2 to 5.4 g/d. No consistent benefits were observed for any outcome with the exception of a modest benefit on triglycerides. A meta-analysis of rejection episodes found no significant benefit on either early (<6 mo posttransplantation) or late episodes. The overall relative risk of having at least one rejection episode in those who received fish oil was 0.91 (95% confidence interval 0.74 to 1.10) in four studies with a follow-up of 1 yr. A meta-analysis of eight RCT of graft survival found no significant benefit (relative risk 1.00, 95% confidence interval 0.96 to 1.05). The available data (mostly derived from older studies with important methodologic limitations) do not demonstrate a consistent, clinically important benefit of fish oil in kidney transplantation.

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“…Some trials found a benefit of fish oil supplementation on renal function (15,17,19,24). This suggests that fish oil could possibly benefit a subset of patients.…”

Section: Discussionmentioning

confidence: 99%

Section: Graft-related Outcomesmentioning

confidence: 99%

Section: Cardiovascular Disease-related Outcomesmentioning

confidence: 99%

Section: Effects Of Fish Oil Supplementation In Subsets Of Patientsmentioning

confidence: 99%

See 2 more Smart Citations

Effects of Fish Oil Supplementation on Kidney Transplantation

Tatsioni

Chung

Sun

et al. 2005

Journal of the American Society of Nephrology

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“…Moreover, some researchers have tried to inhibit allograft rejection by daily administration of PUFA in animals (5)(6)(7)(8) or patients (9)(10)(11). However, results were disappointing, with only slightly improved outcomes.…”

Section: Immunologic Tolerance Is Mediated By Central Mechanisms Permentioning

confidence: 99%