Dietary fish oil decreases C-reactive protein, interleukin-6, and triacylglycerol to HDL-cholesterol ratio in postmenopausal women on HRT

Ciubotaru, Irina; Lee, Ye-Sun; Wander, Rosemary C.

doi:10.1016/s0955-2863(03)00101-3

Cited by 118 publications

(83 citation statements)

References 43 publications

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“…Lowering BP, inflammation, and oxidative stress has been suggested as a mechanism that might explain how high doses of EPA-DHA could slow down loss of kidney function (26,27,37,38). We found, however, no effect of low-dose EPA-DHA on BP and hsCRP (Supplemental Table 2) (18).…”

Section: Discussionmentioning

confidence: 66%

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Effect of Omega-3 Fatty Acids on Kidney Function after Myocardial Infarction

Hoogeveen¹,

Geleijnse

Kromhout

et al. 2014

Clinical Journal of the American Society of Nephrology

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Background and objectives Kidney function gradually decreases with age, and myocardial infarction accelerates this deterioration. Omega-3 (n-3) fatty acids may slow down the decline of kidney function. The effect of marine and plant-derived n-3 fatty acids on kidney function in patients after myocardial infarction was examined.Design, setting, participants, & measurements In the Alpha Omega Trial, 2344 patients with history of myocardial infarction ages 60-80 years old (81% men) were randomized to one of four trial margarines. The patients received an additional targeted amount of 400 mg/d eicosapentaenoic acid and docosahexaenoic acid, 2 g/d a-linolenic acid, eicosapentaenoic acid-docosahexaenoic acid plus a-linolenic acid, or placebo for 40 months. Serum cystatin C and serum creatinine were assessed at baseline and after 40 months. Creatinine-cystatin C-based GFR was estimated with the Chronic Kidney Disease Epidemiology Collaboration equation.Results Patients consumed 19.9 g margarine/d, providing an additional 239 mg/d eicosapentaenoic acid with 159 mg/d docosahexaenoic acid, 1.99 g/d a-linolenic acid, or both in the active treatment groups. After 40 months, compared with baseline, mean (6SD) creatinine-cystatin C-based GFR was 26.9 (612.6), 24.8 (613.4), 26.2 (612.8), and 26.0 (613.0) ml/min per 1.73 m 2 in the placebo, eicosapentaenoic acid-docosahexaenoic acid, a-linolenic acid, and eicosapentaenoic acid-docosahexaenoic acid plus a-linolenic acid groups, respectively. After 40 months, in patients receiving eicosapentaenoic acid-docosahexaenoic acid compared with placebo, the decline in creatinine-cystatin C-based GFR was 2.1 less (95% confidence interval, 0.6 to 3.6; P,0.01) ml/min per 1.73 m 2 ; other comparisons were not statistical significant. Odds ratios (95% confidence intervals) of incident CKD (,60 ml/min per 1.73 m 2 ) and rapid decline of kidney function ($3 ml/min per year) for eicosapentaenoic acid-docosahexaenoic acid compared with placebo were 0.83 (0.58 to 1.18) and 0.85 (0.67 to 1.08), respectively.Conclusions Long-term supplementation with 400 mg/d eicosapentaenoic acid-docosahexaenoic acid provides a small beneficial effect on kidney function in patients with a history of myocardial infarction.

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Section: Discussionmentioning

confidence: 66%

“…Inflammation might be a non-GFR determinant of cysC (23)(24)(25). Anti-inflammatory effects of high-dose EPA-DHA may lower serum cysC production (26)(27)(28)(29)(30). However, we previously showed that 40 months of supplementation with low-dose n-3 fatty acids did not lower the level of hsCRP in statin users (85% of the patients) (18).…”

Section: Discussionmentioning

confidence: 89%

Effect of Omega-3 Fatty Acids on Kidney Function after Myocardial Infarction

Hoogeveen¹,

Geleijnse

Kromhout

et al. 2014

Clinical Journal of the American Society of Nephrology

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“…n-3 PUFA may directly or indirectly trigger anti-inflammatory effects on the pattern of inflammatory cytokines (i.e., TNF␣, IL-1␤, IL-6, IL-8, and interferon-␥) produced by various cell types at sites of inflammation (10). Moreover, anti-inflammatory effects of -3 fatty acids have been studied in humans, with CRP levels believed to reflect a chronic, low-grade inflammatory process, and associated with increased cardiovascular disease (2,9,38,50). Animal studies have shown that fish oil consistently reduced CRP in rat model of hypertension.…”

Section: Discussionmentioning

confidence: 99%

Effect of docosahexaenoic acid monoacylglyceride on systemic hypertension and cardiovascular dysfunction

Morin

Rousseau

Blier

et al. 2015

American Journal of Physiology-Heart and Circulatory Physiology

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Morin C, Rousseau E, Blier PU, Fortin S. Effect of docosahexaenoic acid monoacylglyceride on systemic hypertension and cardiovascular dysfunction. Am J Physiol Heart Circ Physiol 309: H93-H102, 2015. First published April 24, 2015 doi:10.1152/ajpheart.00823.2014 Fatty acid supplementation has been associated with lower blood pressure. Cardiovascular diseases are also known to be linked directly to an increase in -6 and a reduction in -3 fatty acid levels in blood circulation and tissues. To determine the effect of docosahexaenoic acid monoglycerides (MAG-DHA) on blood pressure, lipid profiles, and vascular remodeling in rats fed a high-fat/high-carbohydrate (HFHC) diet. Studies were performed in male rats subjected to 8 wk of HFHC diet supplemented or not with 3 g/day MAG-DHA. After 8 wk of daily MAG-DHA treatment, rats in the HFHC ϩ MAG-DHA group had lower arterial blood pressure and heart rate compared with the HFHC group. Moreover, MAG-DHA prevented the increase aortic wall thickness, whereas lipid analysis of aortic tissues revealed an increase in DHA/AA ratio correlated with the production of resolvin D2 and D3 metabolites. Histological analysis revealed that MAG-DHA prevented the development of LVH in the HFHC group. Serum lipid profile analysis further showed a decrease in total cholesterol (TC) and LDL, including very low-density lipoprotein (VLDL) and triglyceride (TG) levels, together with an increase in HDL levels after 8 wk of MAG-DHA treatment compared with the HFHC group. Furthermore, daily MAG-DHA treatment resulted in reduced proinflammatory marker levels such as CRP, IL-6, TNF␣, and IL-1␤. Altogether, these findings revealed that per os administration of MAG-DHA prevents HFHC-diet induced hypertension and LVH in rats. docosahexaenoic acid; hypertension; cardiac hypertrophy; inflammation DESPITE AGGRESSIVE TREATMENT with current therapies, hypertension and heart failure remain major public health problems due to poor quality of life, frequent hospitalizations, and death (5). New therapeutic approaches are needed to prevent the development of heart failure and reverse the progression of established dysfunction. Current evidence from experimental animal studies, epidemiological studies, and clinical trials suggests that -3 polyunsaturated fatty acids (n-3 PUFA) of marine origin may be protective against cardiovascular disease (5, 26). For example, McLennan et al. (27) reported that docosahexaenoic acid (DHA) was more effective than eicosapentaenoic acid (EPA) in delaying the development of hypertension in spontaneously hypertensive rats (SHR). Moreover, DHA inhibited ischemia-induced cardiac arrhythmias at low dietary intakes in Hooded Wistar rats (27), whereas in the stroke-prone SHR model, dietary DHA intake was found to prevent the development of hypertension (20). Other studies also found that treatment with a mixture of DHA and EPA in animal models of chronic left ventricular (LV) dysfunction resulted in beneficial effects on pressure overload-induced cardiac disease (7,11,12,27,41).Epidemio...

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“…No entanto, como os resultados tenderam a ser mais elevados para a dieta com teor mais alto de isoflavona de soja, seria interessante avaliar a expressão desses biomarcadores durante prazo e/ou quantidades de isoflavona maiores. O uso de alguns medicamentos pelos participantes deste estudo, como anti-hipertensivos e terapia de reposição hormonal, pode ter influenciado os resultados encontrados, pois ainda não estão bem esclarecidos os tipos de alterações que esses fárma-cos produzem na inflamação (53,54).…”

Section: Inflamação Crônica E Dietaunclassified

“…Não houve diferença significativa nos níveis de PCR entre os grupos que receberam a mistura de CLA e o placebo. Alguns autores têm sugerido que o CLA trans-10 cis-12 causa resistência à insulina em homens obesos, levando a efeito desfavorável na inflamação e no desenvolvimento de DCV (54). Entretanto, os efeitos metabólicos da mistura de CLA permaneceram desconhecidos.…”

Section: áCido Graxo Linoléico Conjugado (Cla)unclassified

Papel da dieta na prevenção e no controle da inflamação crônica: evidências atuais

Geraldo

Alfenas

2008

Arq Bras Endocrinol Metab

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Role of Diet on Chronic Inflammation Prevention and Control -Current Evidences.It is known that low chronic inflammation occurs in several stages of non transmissible chronic diseases, including cardiovascular diseases, obesity and diabetes mellitus, among others. Observational studies and clinical trials indicate that diet plays an important role in the reduction of such diseases. the present manuscript discusses the studies that linked diet macronutrient composition and the levels of inflammatory markers. It has been suggested that the consumption of high glycemic index diets, which have low fiber content and are rich in trans fat cause the activation of the immune system, leading to excessive production of pro-inflammatory mediators and the reduction of the anti-inflammatory ones. Although the results are controversial, healthy dietary intakes with the reduction in fat intake (especially trans and saturated fat) and the increase in fruits, vegetables, and whole grain consumption seem to be associated with the improvement in subclinical inflammatory condition.

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Dietary fish oil decreases C-reactive protein, interleukin-6, and triacylglycerol to HDL-cholesterol ratio in postmenopausal women on HRT

Cited by 118 publications

References 43 publications

Effect of Omega-3 Fatty Acids on Kidney Function after Myocardial Infarction

Effect of Omega-3 Fatty Acids on Kidney Function after Myocardial Infarction

Effect of docosahexaenoic acid monoacylglyceride on systemic hypertension and cardiovascular dysfunction

Papel da dieta na prevenção e no controle da inflamação crônica: evidências atuais

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