1998
DOI: 10.1093/jn/128.12.2512
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Dietary Fish Oil Affects Monoaminergic Neurotransmission and Behavior in Rats

Abstract: We studied the effects of a fish oil enriched diet on fatty acid composition of cerebral membranes and on several neurochemical and behavioral variables of monoaminergic function in rats. The frontal cortex, striatum, hippocampus and cerebellum were studied in rats fed fish oil (FPO, 50% salmon oil + 50% palm oil), which provided an (n-6)/(n-3) polyunsaturated fatty acid (PUFA) ratio of 0.14 versus 6. 19 in controls fed a diet containing a mixture of African peanut oil and rapeseed oil. In the FPO group compar… Show more

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Cited by 237 publications
(151 citation statements)
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“…Furthermore, dopamine levels in the frontal cortex of rats fed a PUFAdeficient diet were also reduced (32)(33)(34). Importantly, the opposite trend (increased dopamine levels) was observed in rats fed a PUFA-rich diet (35). A potential role for ␣S in the formation and/or maintenance of synaptic vesicles has been shown in other studies (36,37).…”
Section: Cell Typementioning
confidence: 80%
“…Furthermore, dopamine levels in the frontal cortex of rats fed a PUFAdeficient diet were also reduced (32)(33)(34). Importantly, the opposite trend (increased dopamine levels) was observed in rats fed a PUFA-rich diet (35). A potential role for ␣S in the formation and/or maintenance of synaptic vesicles has been shown in other studies (36,37).…”
Section: Cell Typementioning
confidence: 80%
“…As for dopamine concentrations, frontal cortex serotonin concentrations were increased in rats fed diets supplemented with n-3 PUFA 85 . In line with this, serotonin in the frontal cortex was reduced in piglets fed n-3 and n-6 PUFA-deficient formula for 18 d from birth compared with piglets fed formula supplemented with linoleic acid and alinolenic acid and/or arachidonic acid and DHA 96 .…”
Section: Findings and Mechanisms In Different Mammalsmentioning
confidence: 96%
“…n-3 PUFA-deficient rats had a lower number of D 2 receptors in the frontal cortex 91,92,94 but higher in the nucleus accumbens 93,94 . Rats fed diets supplemented with EPA and DHA had an increased dopamine concentration and D 2 binding possibly as a result of a reduction in monoamine oxidase activity in the frontal cortex compared with rats fed adequate amounts of PUFA 85 .…”
Section: Findings and Mechanisms In Different Mammalsmentioning
confidence: 98%
See 1 more Smart Citation
“…LCn3PUFAs may also increase levels of monoaminergic neurotransmitters in the brain [11], and inhibit inflammation that is associated with depression [9]. The mechanisms underlying depression are complex and, while there is some evidence linking change to cerebrovascular structure and function with depression [12], other evidence suggests that inflammatory changes are central [13].…”
Section: Introductionmentioning
confidence: 99%