Dietary fish intake and the risk of multiple sclerosis: a systematic review and meta-analysis of observational studies

Rezaeizadeh, Hossein; Mohammadpour, Zinat; Bitarafan, Sama; Harirchian, Mohammad Hossein; Ghadimi, Maryam; Homayon, Iman Azar

doi:10.1080/1028415x.2020.1804096

Cited by 5 publications

(3 citation statements)

References 35 publications

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“…Moreover, our findings showed that higher consumption of fish was associated with a decreased risk of MetS, AMD, IBD, and CD but no association between fish consumption and UC was found, for which we found a moderate quality of evidence (79,103,106). Although we also observed a reduced risk of MS, depression, dementia, AD, and hip fracture, and a null association of T2DM and MCI with consumption of fish, respectively, the quality of evidence for these associations was low and further investigation is needed (80,88,94,95,97,102).…”

Section: Fish Consumption and Other Outcomesmentioning

confidence: 64%

Fish consumption in multiple health outcomes: an umbrella review of meta-analyses of observational and clinical studies

H¹,

Wang²,

Peng³

et al. 2023

Ann Transl Med

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Background: Omega-3 polyunsaturated fatty acids are known to be associated with numbers of health benefits, and which can be uptake from fish. The aim of this study was to evaluate the current evidence of associations between consumption of fish and diverse health outcomes. Here, we performed an umbrella review to summarize the breadth, strength, and validity of the evidence derived from meta-analyses and systematic reviews of fish consumption on all health outcomes. Methods:The methodological quality of the included meta-analyses and the quality of the evidence were assessed by the Assessment of Multiple Systematic Reviews (AMSTAR) and the grading of recommendations, assessment, development, and evaluation (GRADE) tools, respectively. The umbrella review identified 91 meta-analyses with 66 unique health outcomes, of which 32 outcomes were beneficial, 34 showed nonsignificant associations and only one was harmful (myeloid leukemia).Results: A total of 17 beneficial associations [all-cause mortality, prostate cancer mortality, cardiovascular disease (CVD) mortality, esophageal squamous cell carcinoma (ESCC), glioma, non-Hodgkin lymphoma (NHL), oral cancer, acute coronary syndrome (ACS), cerebrovascular disease, metabolic syndrome, age-related macular degeneration (AMD), inflammatory bowel disease (IBD), Crohn's disease (CD), triglycerides, vitamin D, high-density lipoprotein (HDL)-cholesterol, and multiple sclerosis (MS)], and eight nonsignificant associations [colorectal cancer (CRC) mortality, esophageal adenocarcinoma (EAC), prostate cancer, renal cancer, ovarian cancer, hypertension, ulcerative colitis (UC), and rheumatoid arthritis (RA)] were evaluated as moderate/high quality of evidence. According to dose-response analyses, consumption of fish, especially fatty types, seems generally safe at one-two servings per week and could exert protective effects.Conclusions: Fish consumption is often associated with a variety of health outcomes, both beneficial and harmless, but only about 34% of the associations were graded as based on a moderate/high quality of evidence, and additional multicenter high quality randomized controlled trials (RCTs) with a large sample size are needed to verify these findings in the future.

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Section: Fish Consumption and Other Outcomesmentioning

confidence: 64%

Fish consumption in multiple health outcomes: an umbrella review of meta-analyses of observational and clinical studies

H¹,

Wang²,

Peng³

et al. 2023

Ann Transl Med

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“…With regard to sh intake, there is some evidence in literature about a protective role towards MS. An OR = 0.69 (0.55-0.87) (23) and a OR = 0.77 (0.64-0.92) (25) were reported in literature for the consumption of 0.5-2.99 fresh sh servings per week between cases and controls. These results have been con rmed in a more recent study by Hedström and coworkers, which assessed an association between an increased risk of MS and a low intake of sh (OR 1.2, 95% CI 1.1-1.4) (26).As regards the association between the intake of milk and dairy products and the development of MS, such hypothesis had been speculated several years ago, also relying on the evidence of molecular mimicry between butyrophilin and myelin oligodendrocyte glycoprotein (MOG) (15,27).…”

Section: Discussionmentioning

confidence: 90%

Diet and Multiple Sclerosis: a population-based study in the city of Biancavilla

Toscano

Chisari

Arena

et al. 2022

Preprint

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Background The influence of dietary habits on the pathogenesis of Multiple Sclerosis (MS) has been a topic of interest for years. The municipality of Biancavilla, in Southern Italy, is considered a high-risk area for MS, with a prevalence of 292.3/100,000 persons and an incidence of 16.8/100,000/year. We investigated the nutritional habits of this population to clarify the reasons of the increased incidence rate of MS recorded in this area in the last decades. Methods In this population-based case-control study conducted in the municipality of Biancavilla, we evaluated the intake frequency of different food products of 60 patients with MS and 174 sex-matched and age-matched controls. A semi-structured standardized questionnaire was administered to explore the weekly consumption of four categories of food (meat, fish, milk/dairy products, fat dressings of vegetable origin) during the periods of childhood-early adolescence (before the age of 15) and during late adolescence-adulthood (after 15 years). Results The intake of meat was not different between cases and controls, nor globally neither considering each type of meat (beef, pork, sheep meat, horse meat, cold meats, sausages, smoked meat, brain). Similarly, no differences were detected in the intake frequency of fish (bluefish, riverfish, smoked fish, crustaceans, mollusks), milk and dairy products of different animal origin, nor in the consumption of fat products of vegetable origin (margarine, olive and seed oils) between cases and controls. Conclusion The results of our study clearly indicate no association between the intake frequency of different food products and MS in the town of Biancavilla.

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“…For example, ω3 anti-inflammatory FAs, which are enriched in foods like mackerel, salmon, tuna, walnuts, and flaxseed oil, or obtained through supplements, provide precursors for increasing the synthesis of specialized pro-resolving lipid mediators including the resolvins and other endogenous factors that mitigate inflammation. Notably, a meta-analysis of observational studies found that fish consumption is associated with a 23% decreased risk of MS [183] . In contrast, arachidonic acid, select other ω6 FAs, and saturated fats (eg [146,147,184] ) should be limited as these lipids fuel the synthesis of pro-inflammatory leukotrienes and prostaglandins [185,186] .…”

Section: Potential Intersections Of Dietary Interventions and Ms-adonmentioning

confidence: 99%

Overview of diet and autoimmune demyelinating optic neuritis: a narrative review

Plafker¹,

Titcomb²,

Zyla-Jackson³

et al. 2023

Immunometabolism

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This review summarizes the cellular and molecular underpinnings of autoimmune demyelinating optic neuritis (ADON), a common sequela of multiple sclerosis and other demyelinating diseases. We further present nutritional interventions tested for people with multiple sclerosis focusing on strategies that have shown efficacy or associations with disease course and clinical outcomes. We then close by discuss the potential dietary guidance for preventing and/or ameliorating ADON.

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Dietary fish intake and the risk of multiple sclerosis: a systematic review and meta-analysis of observational studies

Cited by 5 publications

References 35 publications

Fish consumption in multiple health outcomes: an umbrella review of meta-analyses of observational and clinical studies

Fish consumption in multiple health outcomes: an umbrella review of meta-analyses of observational and clinical studies

Diet and Multiple Sclerosis: a population-based study in the city of Biancavilla

Overview of diet and autoimmune demyelinating optic neuritis: a narrative review

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