Dietary Fibre May Mitigate Sarcopenia Risk: Findings from the NU-AGE Cohort of Older European Adults

Montiel-Rojas, Diego; Nilsson, Andreas; Santoro, Aurelia; Franceschi, Claudio; Bazzocchi, Alberto; Battista, Giuseppe; Groot, Lisette C. P. G. M. de; Feskens, Edith J. M.; Berendsen, A. M.; Pietruszka, Barbara; Januszko, Olga; Fairweather‐Tait, Susan J.; Jennings, Amy; Nicoletti, Claudio; Kadi, Fawzi

doi:10.3390/nu12041075

Cited by 23 publications

(26 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous research in this area has used relatively small sample sizes and a narrower age range of study participants (65–79 years) and did not adjust for important covariates (e.g. socio‐economic status, physical activity level, smoking status and alcohol intake) 27 . The findings of the present study indicate that the divergent changes in the lean and fat components of body mass associated with higher dietary fibre intakes are also allied to improvements in glucose homeostasis and skeletal muscle strength.…”

Section: Discussionmentioning

confidence: 99%

Higher dietary fibre intake is associated with increased skeletal muscle mass and strength in adults aged 40 years and older

Frampton

Murphy

Frost

et al. 2021

J cachexia sarcopenia muscle

View full text Add to dashboard Cite

Background Skeletal muscle mass begins to decline from 40 years of age. Limited data suggest that dietary fibre may modify lean body mass (BM), of which skeletal muscle is the largest and most malleable component. We investigated the relationship between dietary fibre intake, skeletal muscle mass and associated metabolic and functional parameters in adults aged 40 years and older. Methods We analysed cross‐sectional data from the US National Health and Nutrition Examination Survey between 2011 and 2018 from adults aged 40 years and older. Covariate‐adjusted multiple linear regression analyses were used to evaluate the association between dietary fibre intake and BM components (BM, body mass index [BMI], total lean mass, appendicular lean mass, bone mineral content, total fat, trunk fat; n = 6454), glucose homeostasis (fasting glucose, fasting insulin, HOMA2‐IR; n = 5032) and skeletal muscle strength (combined grip strength; n = 5326). BM components and skeletal muscle strength were expressed relative to BM (per kg of BM). Results Higher intakes of dietary fibre were significantly associated with increased relative total lean mass (β: 0.69 g/kg BM; 95% CI, 0.48–0.89 g/kg BM; P < 0.001), relative appendicular lean mass (β: 0.34 g/kg BM; 95% CI, 0.23–0.45 g/kg BM; P < 0.001), relative bone mineral content (β: 0.05 g/kg BM; 95% CI, 0.02–0.07 g/kg BM; P < 0.001) and relative combined grip strength (β: 0.002 kg/kg BM; 95% CI, 0.001–0.003 kg/kg BM; P < 0.001). Conversely, higher dietary fibre intakes were significantly associated with a lower BM (β: −0.20; 95% CI, −0.28 to −0.11 kg; P < 0.001), BMI (β: −0.08 kg/m2; 95%CI, −0.10 to −0.05 kg/m2), relative total fat (β: −0.68 g/kg BM; 95% CI, −0.89 to −0.47 g/kg BM; P < 0.001), relative trunk fat (β: −0.48 g/kg BM; 95%CI, −0.63 to −0.33 g/kg; P < 0.001), fasting glucose (β: −0.01 mmol/L; 95% CI, −0.02 to −0.00 mmol/L; P = 0.017), fasting insulin (β: −0.71 pmol/L; 95% CI, −1.01 to −0.41 pmol/L; P < 0.001) and HOMA2‐IR (β: −0.02 AU; 95% CI, −0.02 to −0.01 AU; P < 0.001). Conclusions Higher dietary fibre intakes are associated with a lower BM and enhanced body composition, characterized by a reduction in fat mass and an increase in lean mass. Higher dietary fibre intakes were also associated with improvements in glucose homeostasis and skeletal muscle strength. Increasing dietary fibre intake may be a viable strategy to prevent age‐associated declines in skeletal muscle mass.

show abstract

Section: Discussionmentioning

confidence: 99%

Higher dietary fibre intake is associated with increased skeletal muscle mass and strength in adults aged 40 years and older

Frampton

Murphy

Frost

et al. 2021

J cachexia sarcopenia muscle

View full text Add to dashboard Cite

show abstract

“…Participants were categorised as having high or low metabolic risk according to the International Diabetes Federation (IDF) definition of metabolic syndrome (MetS) [44], as described elsewhere [45]. Standing waist circumference (WC), midway between the lowest rib and the iliac crest, was measured to the nearest 0.1 cm.…”

Section: Assessment Of Metabolic Riskmentioning

confidence: 99%

Fighting Sarcopenia in Ageing European Adults: The Importance of the Amount and Source of Dietary Proteins

et al. 2020

Self Cite

View full text Add to dashboard Cite

While an adequate protein intake is important for the maintenance of muscle mass during ageing, the amount and source of protein necessary for optimal prevention of sarcopenia remains to be determined. The present study aimed to investigate the influence of the amount and source of dietary proteins on sarcopenia risk in a cohort of 65–79-year-old European adults within the frame of the NU-AGE study. A total of 986 participants were included in the analysis. Skeletal muscle index (SMI), assessed by dual-energy X-ray absorptiometry (DXA), and handgrip strength (HG) were employed to create a continuous sex-specific sarcopenia risk score (SRS). Total amount together with animal- and plant-derived sources of proteins were obtained from a 7-day food record. Differences in SRS were analysed across groups of total protein intake (<0.8 g/body weight (BW); 0.8–<1.0 g/BW; 1.0–<1.2 g/BW; and ≥1.2 g/BW). The association between SRS and the different sources of protein was assessed using isocaloric substitution models adjusted by demographic, medical, and lifestyle factors. A significant linear dose-response relationship was observed, with a lower SRS linked to higher protein intakes. Based on the isocaloric substitution modelling, a reduced SRS was observed when increasing plant protein to the detriment of animal protein, while holding total protein intake constant. Further, this result remained significant after stratifying the analysis by adherence to different levels of protein intake. Our findings suggest that older adults may benefit from increasing protein intakes above current recommendations. Besides total amount, protein source should be considered when promoting health dietary habits in older adults for the prevention of sarcopenia.

show abstract

“…It is also hypothesized that healthy diets rich in fruit and vegetable may protect against metabolic acidosis and reduce proteolysis and amino acid catabolism [ 35 ], thus mitigating sarcopenia risk [ 36 ]. Additionally, an unfavorable dietary pattern, including foods rich in saturated fats may be detrimental for maintenance of muscle health [ 37 ], whereas diets rich in fiber may mitigate sarcopenia risk [ 38 ]. Altogether, the impact of dietary patterns on muscle function of older adults are unlikely to be explained by the action of single nutrients or single biological pathways.…”

Section: Discussionmentioning

confidence: 99%

Healthy Eating Is Associated with Sarcopenia Risk in Physically Active Older Adults

2021

Self Cite

View full text Add to dashboard Cite

Healthy Diet and physical activity may play important roles in the maintenance of muscle health during aging. The aim of the present study was to explore the impact of adherence to healthy dietary patterns on sarcopenia risk in a sample of physically active older men and women, while considering adherence to guidelines on muscle strengthening activities (MSA) and protein intake. Based on a sample of 191 physically active men and women (65–70 years), dietary intake was assessed using a 90-items food-frequency-questionnaire (FFQ) and Healthy Diet Score (HDS) was calculated. Physical activity was assessed by accelerometry and self-report. A sarcopenia risk score (SRS) was derived based on three indicators of muscle health: muscle mass was assessed using bioelectrical impedance and handgrip strength and 5 times sit-to-stand (5-STS) were determined by standardized procedures. Analysis of covariance (ANCOVA) was used to examine differences in SRS and its components across sex-specific tertiles of HDS, with adjustments for covariates including total energy intake, protein intake and MSA. A significant main effect (p < 0.05) of HDS on SRS was observed, where those belonging to the highest HDS tertile had lower SRS compared to those in the lowest tertile. A corresponding significant effect was observed for 5-STS performance, with better performance in those with the highest HDS adherence compared to those with the lowest. The present study supports guidelines emphasizing diet quality beyond amounts of macro- and micronutrients in the prevention of age-related deterioration of muscle health. Importantly, the benefits from healthy dietary patterns are evident in older adults who already adhere to guidelines for health-enhancing physical activity.

show abstract

Dietary Fibre May Mitigate Sarcopenia Risk: Findings from the NU-AGE Cohort of Older European Adults

Cited by 23 publications

References 46 publications

Higher dietary fibre intake is associated with increased skeletal muscle mass and strength in adults aged 40 years and older

Higher dietary fibre intake is associated with increased skeletal muscle mass and strength in adults aged 40 years and older

Fighting Sarcopenia in Ageing European Adults: The Importance of the Amount and Source of Dietary Proteins

Healthy Eating Is Associated with Sarcopenia Risk in Physically Active Older Adults

Contact Info

Product

Resources

About