Dietary fibre alleviates hepatic fat deposition via inhibiting lipogenic gene expression in meat ducks

Qin, Simeng; Han, H Y; Zhang, K.; Ding, Xuemei; Bai, Shiping; Wang, J.; Zeng, Qiufeng

doi:10.1111/jpn.12828

Cited by 13 publications

(8 citation statements)

References 49 publications

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“…Similarly, Huang et al [45] reported that soy lecithin upregulated the gene expression of FAS, acetyl-CoA carboxylase (ACC), and sterol regulatory element binding protein-1 (SREBP-1) in broilers. This is inconsistent with Qin et al [41], who found downregulation of expression of the previously mentioned gene in the liver with increasing DF% in meat ducks' diet, and an increase of the adipose triglyceride lipase. Furthermore, Hosseini et al [18] reported that dietary supplementation of lysolecithin or/and xylanase did not have any effect on hepatic lipogenic gene expression (FAS and L-FABP) of broiler chickens fed on a low energy diet.…”

Section: Discussioncontrasting

confidence: 79%

“…The obtained findings are in line with Beshara et al [31], who found that HDL was slightly higher, with lower TG level for ducks fed different levels of CF. Qin, et al [41], however, stated that higher DF% decreased serum TC and had no significant effect TG, HDL or LDL concentrations in growing ducklings. DF reduced serum LDL and increased HDL [42,43] as fiber interferes with lipid absorption and metabolism through binding to bile acid and cholesterol, consequently lowering serum lipids [44].…”

Section: Discussionmentioning

confidence: 97%

“…The LPL had an important catabolic role and is involved in the hydrolysis of TG producing free fatty acids and glycerol, while FAS is involved in lipogenesis [41] as the enzyme which catalyzes fatty acid synthesis. The increased expression of LPL in this study suggested that increased DF% plays an important role in lipid metabolism in meat ducks.…”

Section: Discussionmentioning

confidence: 99%

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Dietary Fiber and Lysolecithin Supplementation in Growing Ducks: Effect on Performance, Immune Response, Intestinal Morphology and Lipid Metabolism-Regulating Genes

El-Katcha

Soltan

Shewita

et al. 2021

Animals

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The impact of different dietary fiber (DF) levels (with or without lysolecithin supplementation) on growth performance, immune response, expression of some lipid regulating genes and intestinal morphology was assessed in 408 Pekin ducks for 2 months. Soybean hulls were added to the diet to provide four different levels of DF: 2.4 (control diet), 3.8, 5.3, and 6.7% for the first four groups, respectively, while groups 5 to 8 fed the same four levels of DF with lysolecithin addition. Increasing dietary DF non-significantly reduced (p > 0.05) the ducks’ body weight (BW). However, ducks fed on 3.8% DF showed higher BW and improved feed conversion ratio. Lysolecithin supplementation with different DF did not support growth performance. Increasing DF with or without lysolecithin had no effect on serum lipid profile (p > 0.05). However, serum high-density lipoproteins (HDL) concentration was significantly increased with increasing fiber level in diet (p ˂ 0.05). Increasing DF with or without lysolecithin addition increased serum antioxidant activities and improved the immune response in terms of phagocytic and lysozyme activities. The DF level reduced the duodenal villi length and mucosal layer thickness while increased the villi width (p ˂ 0.05). Lysolecithin supplementation to diets ameliorated adverse effects on intestinal morphology. Moreover, DF level in ducks’ diet with or without lysolecithin significantly upregulated the expression of fatty acid synthase and lipoprotein lipase (p ˂ 0.05). Thus, it could be concluded that ducks fed on soybean hulls containing a diet at the level of 4.5% and providing 3.8% fiber level with or without lysolecithin showed the best performance.

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Section: Discussioncontrasting

confidence: 79%

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

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Dietary Fiber and Lysolecithin Supplementation in Growing Ducks: Effect on Performance, Immune Response, Intestinal Morphology and Lipid Metabolism-Regulating Genes

El-Katcha

Soltan

Shewita

et al. 2021

Animals

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“…The RNA isolation and real-time polymerase chain reaction (PCR) were performed as previously described in our laboratory [18]. Briefly, total RNA was isolated from the duodenal and jejunal mucosa by using a TRIZOL reagent (Invitrogen, Carlsbad, CA, USA) according to the manufacturer’s instructions.…”

Section: Methodsmentioning

confidence: 99%

Dietary phosphorus deficiency impaired growth, intestinal digestion and absorption function of meat ducks

Dai

Zhang

et al. 2019

Asian-Australas J Anim Sci

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ObjectiveAn experiment was conducted to investigate the effects of dietary non-phytate phosphorus (nPP) deficiency on intestinal pH value, digestive enzyme activity, morphology, nutrient utilization, and gene expression of NaPi-IIb in meat ducks from 1 to 21 d of age.MethodsA total of 525 one-d-old Cherry Valley ducklings were fed diets (with 7 pens of 15 ducklings, or 105 total ducklings, on each diet) with five levels of nPP (0.22%, 0.34%, 0.40%, 0.46%, or 0.58%) for 21 d in a completely randomized design. Five experimental diets contained a constant calcium (Ca) content of approximately 0.9%. Body weight (BW), body weight gain (BWG), feed intake (FI), and feed to gain ratio (F:G) were measured at 14 and 21 d of age. Ducks were sampled for duodenum and jejunum digestion and absorption function on 14 and 21 d. Nutrient utilization was assessed using 25- to 27-d-old ducks.ResultsThe results showed ducks fed 0.22% nPP had lower (p<0.05) growth performance and nutrient utilization and higher (p<0.05) serum Ca content and alkaline phosphatase (ALP) activity. When dietary nPP levels were increased, BW (d 14 and 21), BWG and FI (all intervals), and the serum phosphorus (P) content linearly and quadratically increased (p<0.05); and the jejunal pH value (d 14), duodenal muscle layer thickness (d 14), excreta dry matter, crude protein, energy, Ca and total P utilization linearly increased (p<0.05); however, the serum ALP activity, jejunal Na+-K+-ATPase activity, and duodenal NaPi-IIb mRNA level (d 21) linearly decreased (p<0.05).ConclusionThe results indicated that ducks aged from 1 to 21 d fed diets with 0.22% nPP had poor growth performance related to poor intestinal digestion and absorption ability; but when fed diets with 0.40%, 0.46%, and 0.58% nPP, ducks presented a better growth performance, intestinal digestion and absorption function.

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“…Likes other avian species, dietary fiber was also beneficial to duck growth and gut health and ducks could adapt to a wide dietary crude fiber range from 3.09 to 7.52% ( Han et al, 2017 ). Furthermore, ducks fed with high dietary crude fiber levels had increased gizzard development, jejunal morphology, energy retention, excreta nutrients availability, and standardized ileal digestibility of amino acids, and high dietary fiber also alleviated hepatic fat deposition via inhibiting lipogenic gene expression in meat ducks ( Han et al, 2017 ; Qin et al, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

Effects of Total Dietary Fiber on Cecal Microbial Community and Intestinal Morphology of Growing White Pekin Duck

Hao

Shen

et al. 2021

Front. Microbiol.

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The current study was to investigate the effects of total dietary fiber (TDF) on growth performance, cecal structure, cecal microbial community, and short-chain fatty acids (SCFAs) profiles in the cecum of growing White Pekin ducks. A total of 108 male Pekin ducks of 14-days-old were randomly allocated and fed diets containing 12.4, 14.7, and 16.2% TDF for 35 days. Each dietary treatment consisted of six replicates with six birds each. The results showed that 14.7 and 16.2% TDF treatments promoted growth performance relative to 12.4% TDF treatments (P < 0.05). A total of 14.7 and 16.2% TDF treatments significantly elevated villus height, the ratio of villus height to crypt depth and muscle layer thickness of cecum, and lowered crypt depth compared with 12.4% TDF treatment (P < 0.05). Simultaneously, 14.7 and 16.2% TDF treatments up-regulated Claudin-1 mRNA expression of barrier genes in the cecum compared with 12.4% TDF (P < 0.05). Butyrate-producing bacteria like Oscillopiraceae affiliating to the phyla Firmicutes were observed as a biomarker in the 16.2% TDF. Higher concentration of butyrate in the cecum was obtained in the 14.7% TDF compared with 12.4 and 16.2% TDF (P < 0.05). The concentrations of isobutyrate, valerate, and isovalerate in the cecum were significantly increased in the 16.2% TDF compared with 12.4 and 14.7% TDF (P < 0.05). Meanwhile, the abundance of genus UCG-005 and Enterococcus was positive correlations with isobutyrate and valerate (P < 0.05). However, the concentration of propionate in the cecum significantly decreased in 14.7 and 16.2% TDF treatments relative to 12.4% TDF treatments (P < 0.05). In summary, increasing TDF levels improved growth performance, cecal histomorphology, and barrier function of meat ducks and it might be mediated by the changes of microbiota communities, especially bloom of SCFAs-producing bacteria, which facilitated the interaction between intestinal mucosa and microbiota.

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Dietary fibre alleviates hepatic fat deposition via inhibiting lipogenic gene expression in meat ducks

Cited by 13 publications

References 49 publications

Dietary Fiber and Lysolecithin Supplementation in Growing Ducks: Effect on Performance, Immune Response, Intestinal Morphology and Lipid Metabolism-Regulating Genes

Dietary Fiber and Lysolecithin Supplementation in Growing Ducks: Effect on Performance, Immune Response, Intestinal Morphology and Lipid Metabolism-Regulating Genes

Dietary phosphorus deficiency impaired growth, intestinal digestion and absorption function of meat ducks

Effects of Total Dietary Fiber on Cecal Microbial Community and Intestinal Morphology of Growing White Pekin Duck

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