Dietary Fiber Increases Butyrate-Producing Bacteria and Improves the Growth Performance of Weaned Piglets

Zhao, Jinbiao; Liu, Ping; Wu, Yi; Guo, Pingting; Liu, Ling; Ma, Ning; Levesque, Crystal L; Chen, Yiqiang; Zhao, Jinshan; Zhang, Jie; Ma, Xi

doi:10.1021/acs.jafc.8b02545

Cited by 115 publications

(116 citation statements)

References 43 publications

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“…A good gut microbiota is able to benefit the host by regulating physiological process and mucosal immunity such as suppressing proliferation of enteric pathogens [20], strengthening integrity of intestinal barrier on epithelial cells [21,22] and producing antimicrobial peptides in mucus layer [23]. In this study, Bacteroides and Firmicutes were the two dominant phyla, and Prevotella was the dominant bacterial species at the genus level, corresponding with the previous studies in which the most abundant phyla detected in the fecal samples of weaned piglets were Firmicutes and Bacteroides [24][25][26][27]. This research showed that Firmicutes abundance was increased in the CPB group but decreased in the antibiotic group.…”

Section: Discussionsupporting

confidence: 85%

Dietary Supplementation with Compound Probiotics and Berberine Alters Piglet Production Performance and Fecal Microbiota

Yang

Chang

et al. 2020

Animals

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Simple Summary: In order to find antibiotic substitutes for weaned piglet health and growth, compound probiotics and berberine (CPB) were selected in this study. The results indicated that CPB could replace antibiotics to improve piglet health and decrease mortality, diarrhea and rejection rates. CPB was also able to regulate fecal microbiota as well as improve protein digestibility and serum biochemical parameters. Therefore, CPB might be a good antibiotic alternative in piglet production performance.Abstract: This study was conducted to investigate the effects of dietary supplementation with compound probiotics and berberine (CPB) on growth performance, nutrient digestibility and fecal microflora in weaned piglets. A total of 200 piglets 35 days old were randomly allocated to 5 groups, 4 replications in each group, and 10 piglets in each replication. Group A was the basal diet; group B was supplemented with antibiotics and zinc oxide; groups C, D and E were supplemented with 0.06%, 0.12% and 0.18% CPB, respectively. The experimental period was 42 d. The results indicated that there were no significant differences in average daily feed intake (ADFI), average daily gain (ADG) and feed conversion rate (FCR) among five groups (p > 0.05). However, mortality, diarrhea and rejection rates in the control group were higher than that in other groups. CPB could increase protein digestibility and serum IgG content (p < 0.05), while it could decrease serum urea nitrogen content and alkaline phosphatase activity (p < 0.05). Analysis of fecal microbiota showed that the relative abundances of Bacteroides and Firmicutes were increased, while the relative abundances of opportunistic pathogens such as Spirochaetae and Protebactreria were dramatically decreased in piglets fed with CPB or antibiotics, compared with the control group. Furthermore, CPB intervention increased the relative abundances of Prevotella_9, Megasphaera and Prevotella_2, while decreased the relative abundance of Prevotellaceae_NK3B31_group. Correlation analysis revealed that there was good correlation between serum indexes and fecal microbiota. It was suggested that CPB might be a promising antibiotic alternative for improving piglet health and immunity, decreasing mortality by positively altering gut microbiota.

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Section: Discussionsupporting

confidence: 85%

Dietary Supplementation with Compound Probiotics and Berberine Alters Piglet Production Performance and Fecal Microbiota

Yang

Chang

et al. 2020

Animals

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“…The human gut microbiota is a complex community and is important for the health status of the host . Alterations in the gut microbiota and diet have been found to be associated with the pathogenesis of several human diseases . Probiotic supplementation has been found to be associated with improvements in health and the intestinal microbial composition, and the supplementation of L. fermentum has been shown to modulate the intestinal microbiota in piglets .…”

Section: Discussionmentioning

confidence: 99%

“…[33][34][35] Alterations in the gut microbiota and diet have been found to be associated with the pathogenesis of several human diseases. [36][37][38][39][40] Probiotic supplementation has been found to be associated with improvements in health and the intestinal microbial composition, 24,41 and the supplementation of L. fermentum has been shown to modulate the intestinal microbiota in piglets. 42 As the global composition and the presence of pathogens or beneficial bacteria are relevant to the host's health, we analyzed the composition of the test animals over 13 weeks of feeding of bacterial strains.…”

Section: Discussionmentioning

confidence: 99%

In vivo safety assessment of Lactobacillus fermentum strains, evaluation of their cholesterol‐lowering ability and intestinal microbial modulation

Thumu

Halami

2019

J Sci Food Agric

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BACKGROUND Despite the growing importance of probiotics apparent health benefits, an impediment to the use of new probiotic cultures is their safety. Hence there is a need to strictly examine the biosafety as well as health benefits of probiotics in in vivo model systems. RESULTS In this study, two lactic acid bacterial (LAB) cultures Lactobacillus fermentum NCMR 2826 and FIX proven for their in vitro probiotic properties were investigated for their in vivo safety in Wistar rats. An acute toxicity study (14 days) with a high dose of biomass (1016 colony‐forming units (CFU) mL−1) followed by a subchronic test for 13 weeks with oral feeding of the probiotic cultures in three different doses (107, 108 and 1010 CFU mL−1) on a daily basis revealed the safety of the L. fermentum cultures. The probiotic feeding had no toxic effects on survival, body weight and food consumption with any of the dosages used throughout the treatment period. No statistically significant changes in relative organ weights and serum biochemical and hematological indices were found between the control and the probiotic fed animals. In addition to the safety attributes, the L. fermentum culture fed rats showed reduced serum cholesterol levels, macrovesicular steatosis and hepatocyte ballooning compared with control animals. Further, quantification of intestinal microbiota using real‐time polymerase chain reaction (PCR) analysis from animal feces indicated a significant increase and stability of Lactobacillus and Bifidobacterium counts but a decrease of Escherichia coli numbers. CONCLUSION This study of safety and beneficial features highlights the use of the two native L. fermentum isolates as potential probiotic food supplements. © 2019 Society of Chemical Industry

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“…It has been reported PHB as an alternative diet additive for MCAs can supply short‐chain‐length fatty acids (SCFAs) for commensal bacteria and host cells during PHB degradation in the digestive tracts, which aids the maintenance of a balanced microbiome in the gastrointestinal tract . Similar to these reports, microbial extracellular hydrolytic enzymes in the digestive tract generate 3HB and oligo‐3HB, both of which can function as an energy source and stimulate the activity of digestive enzymes for better piglet growth performance . The growth‐promoting effect of PHB on the fish could be attributed to PHB degradation and the accompanying release of oligo‐3HB and monomeric β‐hydroxybutyric acid (3HB), which have documented positive effects on animal and human health .…”

Section: Discussionmentioning

confidence: 71%

Microbial Poly‐3‐Hydroxybutyrate (PHB) as a Feed Additive for Fishes and Piglets

Wang

Jiang

et al. 2019

Biotechnology Journal

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The large‐scale use of petrochemical‐based plastics is damaging our environment. Discarded plastics are harmful to both marine and land animals, sometimes causing death when ingested. Biodegradable plastics have gained attentions from the public and the academia to reduce environmental burdens. Poly‐3‐hydroxybutyrate (PHB), the simplest and the best‐studied bioplastic member of the polyhydroxyalkanoate (PHA) family synthesized by many bacteria, has been studied as a feed additive for large yellow croaker fish and weaned piglets. The fish grow faster and gain more weight when 1% and 2% PHB is added as a feed additive, accompanied by increased survival rates. Weaned piglets are found to grow normally and showed no significant change in average daily weight gains, average daily feed intakes, feed efficiency, and organ developments when 0.5% PHB is added to the feed. It can therefore be concluded that biodegradable and biocompatible PHB is not harmful as a feed additive for marine large yellow croakers and sensitive weaned piglets. PHB therefore holds great promise as a plastic that combines biodegradability and biocompatibility with good tolerability as a feed supplement for animals.

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Dietary Fiber Increases Butyrate-Producing Bacteria and Improves the Growth Performance of Weaned Piglets

Cited by 115 publications

References 43 publications

Dietary Supplementation with Compound Probiotics and Berberine Alters Piglet Production Performance and Fecal Microbiota

Dietary Supplementation with Compound Probiotics and Berberine Alters Piglet Production Performance and Fecal Microbiota

In vivo safety assessment of Lactobacillus fermentum strains, evaluation of their cholesterol‐lowering ability and intestinal microbial modulation

Microbial Poly‐3‐Hydroxybutyrate (PHB) as a Feed Additive for Fishes and Piglets

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