Dietary Fiber and Gut Microbiota in Renal Diets

Camerotto, Carla; Cupisti, Adamasco; Muzio, Fulvio; Gallieni, Maurizio

doi:10.3390/nu11092149

Cited by 40 publications

(34 citation statements)

References 84 publications

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“…increase in physical activity and improvement of diet 38 . Indeed, one can recommend a fiber-rich diet because it shortens intestinal transit time (via bulking effect 39 ) and, additionally, is a part of healthy dietary patterns that are associated with lower mortality in CKD patients 40 . However, based on the high prevalence of bloating among CKD patients in our study, as well as that some CKD patients require fluid intake restriction, the recommendation of a diet rich in fiber should be given cautiously.…”

Section: Discussionmentioning

confidence: 99%

Constipation and the Quality of Life in Conservatively Treated Chronic Kidney Disease Patients: A Cross-sectional Study

Ruszkowski¹,

Heleniak²,

Król³

et al. 2020

Int. J. Med. Sci.

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Background: Constipation is a common gastrointestinal disorder that in general population is associated with worse health-related quality of life (HRQoL). The epidemiology of constipation has not been reliably determined in conservatively-treated CKD patients. We aimed to determine the prevalence of constipation and constipation-related symptoms in conservatively-treated CKD patients, to find factors associated with their altered prevalence ratio (PR), and to verify the associations between constipation and HRQoL. Methods: In this cross-sectional study, 111 conservatively-treated CKD outpatients fulfilled questionnaires that included questions addressing HRQoL (SF-36v2®), constipation-related symptoms (The Patient Assessment of Constipation‐Symptoms questionnaire), the Bristol stool form scale (BSFS), Rome III criteria of functional constipation (FC), and frequency of bowel movement (BM). Results: Depending on the used definition, the prevalence of constipation was 6.6-28.9%. Diuretics and paracetamol were independently associated with increased PR of BSFS-diagnosed constipation (PR 2.86, 95% CI 1.28-6.37, P = 0.01) and FC (PR 2.67, 95% CI 1.07-6.64, P = 0.035), respectively. The most commonly reported symptoms were bloating (50.9%) and straining to pass a BM (42.7%). Abdominal discomfort (37.3%) was independently associated with worse scores in all analyzed HRQoL domains. In multiple regressions, FC and having <7 BM/week, but not BSFS-diagnosed constipation, were associated with lower scores in several HRQoL domains. Conclusions: Constipation and related symptoms are prevalent in CKD patients. FC and decreased frequency of defecation, but not BSFS-diagnosed constipation, are associated with worse assessment of HRQoL in conservatively-treated CKD patients.

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Section: Discussionmentioning

confidence: 99%

Constipation and the Quality of Life in Conservatively Treated Chronic Kidney Disease Patients: A Cross-sectional Study

Ruszkowski¹,

Heleniak²,

Król³

et al. 2020

Int. J. Med. Sci.

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“…Moreover, it decreases the bacterial generation of uremic toxins. 53 High dietary fiber intake is also helpful in reducing inflammation. Among 650 maintenance hemodialysis patients 54 fiber intake reduced Creactive protein, and oxidative stress, which may also impact graft survival.…”

Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 99%

A Narrative Review of Dietary Approaches for Kidney Transplant Patients

Cyrino

Galpern

Moore

et al. 2021

Kidney International Reports

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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“…MD could also positively impact the microbiome. Considering its plasticity and the nutrition capacity to dysregulate intestinal bacterial composition and physiological functions, dietary adjustments could be considered therapeutic interventions in these pathological conditions [ 162 ]. Nutritional strategies directly targeting gut microbiota might represent a correct way to restore human-microbiome relationship [ 163 ].…”

Section: Mediterranean Diet Inflammaging and Ckd/rrt Patientsmentioning

confidence: 99%

Nutrition-Based Management of Inflammaging in CKD and Renal Replacement Therapies

et al. 2021

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Access to renal transplantation guarantees a substantial improvement in the clinical condition and quality of life (QoL) for end-stage renal disease (ESRD) patients. In recent years, a greater number of older patients starting renal replacement therapies (RRT) have shown the long-term impact of conservative therapies for advanced CKD and the consequences of the uremic milieu, with a frail clinical condition that impacts not only their survival but also limits their access to transplantation. This process, referred to as “inflammaging,” might be reversible with a tailored approach, such as RRT accompanied by specific nutritional support. In this review, we summarize the evidence demonstrating the presence of several proinflammatory substances in the Western diet (WD) and the positive effect of unprocessed food consumption and increased fruit and vegetable intake, suggesting a new approach to reduce inflammaging with the improvement of ESRD clinical status. We conclude that the Mediterranean diet (MD), because of its modulative effects on microbiota and its anti-inflammaging properties, may be a cornerstone in a more precise nutritional support for patients on the waiting list for kidney transplantation.

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Dietary Fiber and Gut Microbiota in Renal Diets

Cited by 40 publications

References 84 publications

Constipation and the Quality of Life in Conservatively Treated Chronic Kidney Disease Patients: A Cross-sectional Study

Constipation and the Quality of Life in Conservatively Treated Chronic Kidney Disease Patients: A Cross-sectional Study

A Narrative Review of Dietary Approaches for Kidney Transplant Patients

Nutrition-Based Management of Inflammaging in CKD and Renal Replacement Therapies

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