Dietary Fermented Rice Bran Is an Effective Modulator of Ulcerative Colitis in Experimental Animal

Abstract

Ulcerative colitis (UC) is an inflammatory disorder with colon and rectum, characterized by recurring bloody diarrhea due to microbial dysfunction and some autoimmune response. Scientists have linked microbial disruption in the gut to several chronic conditions such as UC and other types of inflammatory bowel disease (IBD). Surprisingly, our gastrointestinal tract contains more than 100 trillion microbial cells. Some microbes in the gut microbiome are friendly bacteria that can help to treat UC by influencing metabolism, nutrition, immune function, and more in the gut. The conventional medical treatment of UC relies on the use of amino-salicylates, corticosteroids, immunosuppressive drugs, glucocorticoids, and antibiotics. Multiple new mechanisms in the treatment of UC are being developed and many are showing promising results in ulcerative colitis. Still need scientific evidence to support the role of gut microbiota in the etiology of UC. The dietary fermented rice bran (DFRB) may include the active potential for the treatment of ulcerative colitis. The DFRB may attenuate intestinal inflammation by regulating gut permeability for cellular infiltration and maintenance of luminal safety with favorable efficacy in UC. In this chapter, we discussed and summarized the insight mechanism of DFRB’s modulatory activities for the management or treatment of ulcerative colitis.