Dietary fatty acid metabolism: New insights into the similarities of lipid metabolism in humans and hamsters

Berriozabalgoitia, Alaitz; Gordoa, Juan Carlos Ruiz de; Amores, G.; Virto, Mailo

doi:10.1016/j.fochms.2021.100060

Cited by 2 publications

(3 citation statements)

References 37 publications

(78 reference statements)

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“…The differential changes in plasma lipid fractions among the hamster groups were reflected in the plasma FA profiles, as has been previously observed in hamsters [21]. The OO21 diet only caused an increase in TGs, which was reflected in an increase in the proportions of OA and stearic acid, which are the main contents of these types of lipids [9], while linoleic acid is the main FA in CE, whose concentration decreased in the plasma of the OO21-diet-fed hamsters in relation to total FAs.…”

Section: Discussionsupporting

confidence: 76%

“…The details of the plasma FA composition (molar concentration) are shown in Supplementary Table S3. The FA profiles of the plasma, in molar percentages, were very similar in both groups that were fed a normal-fat diet, regardless of the type of fat ingested, as we previously described [21]. Figure 2 shows the plasma FA in which the molar proportion changed when comparing hamsters fed a normal-fat diet and a high-fat diet.…”

Section: Hamsters' General Performance and Plasma Parameterssupporting

confidence: 68%

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Normal-Fat vs. High-Fat Diets and Olive Oil vs. CLA-Rich Dairy Fat: A Comparative Study of Their Effects on Atherosclerosis in Male Golden Syrian Hamsters

et al. 2023

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The relationship between milk fat intake (because of its high saturated fatty acid content) and the risk of suffering from cardiovascular diseases remains controversial. Thus, Golden Syrian hamsters were fed two types of fat—sheep milk fat that was rich in rumenic (cis9,trans11-18:2) and vaccenic (trans11-18:1) acids and olive oil—and two doses (a high- or normal-fat diet) for 14 weeks, and markers of lipid metabolism and atherosclerosis evolution were analyzed. The results revealed that the type and percentage of fat affected most plasma biochemical parameters related to lipid metabolism, while only the expression of five (CD36, SR-B1, ACAT, LDLR, and HMG-CoAR) of the studied lipid-metabolism-related genes was affected by these factors. According to aortic histology, when ingested in excess, both fats caused a similar increase in the thickness of fatty streaks, but the high-milk-fat-based diet caused a more atherogenic plasma profile. The compositions of the fats that were used, the results that were obtained, and the scientific literature indicated that the rumenic acid present in milk fat would regulate the expression of genes involved in ROS generation and, thus, protect against LDL oxidation, causing an effect similar to that of olive oil.

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Section: Discussionsupporting

confidence: 76%

Section: Hamsters' General Performance and Plasma Parameterssupporting

confidence: 68%

Normal-Fat vs. High-Fat Diets and Olive Oil vs. CLA-Rich Dairy Fat: A Comparative Study of Their Effects on Atherosclerosis in Male Golden Syrian Hamsters

et al. 2023

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“…Serum AST and ALT are also dramatically increased, indicating that liver injury in this model may be due to lipotoxicity through excessive lipid intake. The hamster was reported to be more similar to human lipid metabolism than other rodents such as rat and mouse [ 36 ]. To develop a model with both dyslipidemia and steatohepatitis that frequently occur in humans, we fed SD rats with longer term (10 weeks) and an extra 0.5% cholate in HFD.…”

Section: Discussionmentioning

confidence: 99%

CS27109, A Selective Thyroid Hormone Receptor-β Agonist Alleviates Metabolic-Associated Fatty Liver Disease in Murine Models

Huang¹,

Deng²,

Wang³

et al. 2023

International Journal of Endocrinology

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Background/Aim. Thyroid hormone receptor-β (THR-β) agonists play crucial roles in dyslipidemia and metabolic associated fatty liver disease (MAFLD). We developed a novel oral and liver-targeted THR-β agonist, CS27109, and evaluated its efficacy in the treatment of metabolic disorders. Materials and Methods. We evaluated in vitro and in vivo efficacy and/or safety of CS27109 along with MGL3196 (a phase III THR-β agonist). Results. CS27109 showed pronounced activity and selectivity to THR-β and favorable PK properties, which was equivalent to MGL3196. In the hamster model, animals treated with a high dose of CS27109 showed equivalent reductions in serum TC and LDL-c with groups treated with MGL3196. In the rat model, CS27109 and MGL3196 reduced serum ALT, TC, TG, LDL-c, liver weight ratio, and liver steatosis. CS27109 simultaneously decreased liver TG and TC, and MGL3196 additionally reduced AST. In the mouse model, CS27109 dose-dependently reduced serum AST, ALT, liver inflammation, and NAS score, and also downregulated TC, LDL-c, liver steatosis, and fibrosis, but not in a dose-dependent manner. MGL3196 revealed an equivalent effect with CS27109 in that model. CS27109 also exhibited tolerable toxicity to the heart. Conclusions. CS27109 shows comparative in vitro and in vivo efficacy with MGL3196, suggesting its potential therapeutic application in the treatment of MAFLD such as dyslipidemia and steatohepatitis.

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Dietary fatty acid metabolism: New insights into the similarities of lipid metabolism in humans and hamsters

Cited by 2 publications

References 37 publications

Normal-Fat vs. High-Fat Diets and Olive Oil vs. CLA-Rich Dairy Fat: A Comparative Study of Their Effects on Atherosclerosis in Male Golden Syrian Hamsters

Normal-Fat vs. High-Fat Diets and Olive Oil vs. CLA-Rich Dairy Fat: A Comparative Study of Their Effects on Atherosclerosis in Male Golden Syrian Hamsters

CS27109, A Selective Thyroid Hormone Receptor-β Agonist Alleviates Metabolic-Associated Fatty Liver Disease in Murine Models

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