Dietary fat modulation of left ventricular ejection fraction in the marmoset due to enhanced filling

McLennan, Peter L; Barnden, Leighton; Bridle, Thelma M.; Abeywardena, M. Y.; Charnock, John S.

doi:10.1093/cvr/26.9.871

Cited by 69 publications

(49 citation statements)

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“…16 Dietary n-3 PUFA reduced the susceptibility to arrhythmias in the present study, as in other studies. 10 -15 The reduced loss of K ϩ during ischemia may be indicative of effects on ion channels or exchange mechanisms that lead to changes in K ϩ conductance 26 and altered arrhythmic potential.…”

Section: Effects Of Dietary Lipids Onsupporting

confidence: 89%

“…In support of this premise, fish oil feeding increases left ventricular end-diastolic volume and ejection fraction in nonhuman primates and reduces rate pressure product, which may be indicative of low myocardial oxygen consumption (MVO 2 ). 16 We tested the hypothesis that n-3 PUFA incorporation into myocardial membranes has direct effects on heart function, particularly after ischemia, additional to previously reported effects on arrhythmia, thrombosis, and vascular function. We used the erythrocyte-perfused isolated working heart, which provides optimal oxygen delivery and permits assessment of hemodynamic function and metabolism under controlled physiologically relevant conditions.…”

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confidence: 99%

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Cardiac Membrane Fatty Acid Composition Modulates Myocardial Oxygen Consumption and Postischemic Recovery of Contractile Function

2002

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Background-Regular fish consumption is associated with low cardiovascular disease morbidity and mortality. Fish oils modify cardiac membrane phospholipid fatty acid composition with potent antiarrhythmic effects. We tested the effects of dietary fish oil on ventricular hemodynamics and myocardial oxygen consumption (MVO 2 ). Methods and Results-Male Wistar rats were fed for 16 weeks on a reference diet rich in n-6 polyunsaturated fatty acids (PUFA), a diet rich in saturated animal fat (SAT), or a diet rich in n-3 PUFA from fish oil. Isolated working hearts were perfused with porcine erythrocytes (40% hematocrit) at 75 mm Hg afterload with variable preload (5 to 20 mm Hg) or with low coronary flow ischemia with maintained afterload, preload, and heart rate, then reperfused. MVO 2 was low and coronary perfusion reserve high in n-3 PUFA hearts, and cardiac output increased with workload. The n-3 PUFA reduced ischemic markers-acidosis, K ϩ , lactate, and creatine kinase-and increased contractile recovery during reperfusion. SAT hearts had high MVO 2 , low coronary perfusion reserve, and poor contractile function and recovery. Dietary differences in MVO 2 were abolished by KCl arrest (basal metabolism) or ruthenium red (3.4 mol/L) but not by ryanodine (1 nmol/L). Fish oil or ryanodine, but not ruthenium red, prevented ventricular fibrillation in reperfusion. Conclusions-Dietary fish oil directly influenced heart function and improved cardiac responses to ischemia and reperfusion. The n-3 PUFA reduced oxygen consumption at any given work output and increased postischemic recovery. Thus, direct effects on myocardial function may contribute to the altered cardiovascular disease profile associated with fish consumption.

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Section: Effects Of Dietary Lipids Onsupporting

confidence: 89%

mentioning

confidence: 99%

Cardiac Membrane Fatty Acid Composition Modulates Myocardial Oxygen Consumption and Postischemic Recovery of Contractile Function

2002

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“…85 In addition, EPA and DHA may prevent the myosin heavy chain isoform α to β switch, a marker of HF and left ventricular hypertrophy. 86 Results of the Cardiovascular Health Study 87 seem to confirm in older adults the findings previously shown in nonhuman primates 88 of an association between fish intake and incremental stroke volume due to improvement of early and, possibly, late diastolic filling. Recently, chronic n-3 PUFA administration in athletes has been reported to reduce heart rate and oxygen consumption during exercise without a decrement in performance, in part due to improved energy production and utilization by cardiac myocytes.…”

Section: Cardiac Hemodynamics Cardiac Functionsupporting

confidence: 64%

Uses and benefits of omega-3 ethyl esters in patients with cardiovascular disease

Levantesi

Silletta²,

Marchioli³

2010

JMDH

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Much evidence on the favorable effects of omega-3 ethyl esters on cardiovascular morbidity and mortality has been obtained in studies performed in healthy subjects and in different clinical settings. Here the clinical effects of omega-3 ethyl ester administration in patients with previous myocardial infarction or heart failure are reviewed, together with a discussion of underlying mechanisms of action. The pharmacokinetic and pharmacodynamic properties of omega-3 ethyl esters, as well as evidence concerning their safety and tolerability, are also reported.

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“…8 In nonhuman primates, fish oil enhances left ventricular diastolic function. [9][10] In humans, fish oil supplementation lowers blood pressure, 11 reduces markers of systemic inflammation, 12 attenuates vasoconstrictive responses to angiotensin II, [13][14] improves arteriolar wall compliance, 15 and improves left ventricular diastolic filling. 16 Considerable epidemiological, clinical trial, and animalexperimental evidence also points to antiarrhythmic effects of n-3 fatty acids in fish, [17][18][19][20][21][22][23][24] which decrease excitability and cytosolic calcium fluctuations of ventricular myocytes via inhibition of Na ϩ and L-type Ca ϩϩ channels.…”

Section: Discussionmentioning

confidence: 99%

Fish Intake and Risk of Incident Atrial Fibrillation

et al. 2004

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Background-Atrial fibrillation (AF) is the most common arrhythmia in clinical practice and is particularly common in the elderly. Although effects of fish intake, including potential antiarrhythmic effects, may favorably influence risk of AF, relationships between fish intake and AF incidence have not been evaluated. Methods and Results-In a prospective, population-based cohort of 4815 adults Նage 65 years, usual dietary intake was assessed at baseline in 1989 and 1990. Consumption of tuna and other broiled or baked fish correlated with plasma phospholipid long-chain n-3 fatty acids, whereas consumption of fried fish or fish sandwiches (fish burgers) did not. AF incidence was prospectively ascertained on the basis of hospital discharge records and annual electrocardiograms. During 12 years' follow-up, 980 cases of incident AF were diagnosed. In multivariate analyses, consumption of tuna or other broiled or baked fish was inversely associated with incidence of AF, with 28% lower risk with intake 1 to 4 times per week (HRϭ0.72, 95% CIϭ0.58 to 0.91, Pϭ0.005), and 31% lower risk with intake Ն5 times per week (HRϭ0.69, 95% CIϭ0.52 to 0.91, Pϭ0.008), compared with Ͻ1 time per month (P trendϭ0.004). Results were not materially different after adjustment for preceding myocardial infarction or congestive heart failure. In similar analyses, fried fish/fish sandwich consumption was not associated with lower risk of AF. Conclusions-Among elderly adults, consumption of tuna or other broiled or baked fish, but not fried fish or fish sandwiches, is associated with lower incidence of AF. Fish intake may influence risk of this common cardiac arrhythmia.

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Dietary fat modulation of left ventricular ejection fraction in the marmoset due to enhanced filling

Abstract: Dietary fish oil and sunflower seed oil increased the left ventricular ejection fraction in the marmoset monkey by enhancing ventricular filling, thus providing an energy sparing promotion of diastolic relaxation.

Cited by 69 publications

References 0 publications

Cardiac Membrane Fatty Acid Composition Modulates Myocardial Oxygen Consumption and Postischemic Recovery of Contractile Function

Cardiac Membrane Fatty Acid Composition Modulates Myocardial Oxygen Consumption and Postischemic Recovery of Contractile Function

Uses and benefits of omega-3 ethyl esters in patients with cardiovascular disease

Fish Intake and Risk of Incident Atrial Fibrillation

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