2015
DOI: 10.3945/ajcn.115.116046
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Dietary fat intake and risk of cardiovascular disease and all-cause mortality in a population at high risk of cardiovascular disease

Abstract: Intakes of MUFAs and PUFAs were associated with a lower risk of CVD and death, whereas SFA and trans-fat intakes were associated with a higher risk of CVD. The replacement of SFAs with MUFAs and PUFAs or of trans fat with MUFAs was inversely associated with CVD. This trial was registered at www.controlled-trials.com as ISRCTN 35739639.

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Cited by 224 publications
(122 citation statements)
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References 31 publications
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“…There is a need for rendering food-based guidelines more practical, scientifically sound, and easily understandable. When we considered isocaloric replacement of MUFA by SFA we observed a higher mortality risk, in accordance with results from previous studies [26,30], denoting the importance of not considering all fats as detrimental.…”
Section: Discussionsupporting
confidence: 90%
See 1 more Smart Citation
“…There is a need for rendering food-based guidelines more practical, scientifically sound, and easily understandable. When we considered isocaloric replacement of MUFA by SFA we observed a higher mortality risk, in accordance with results from previous studies [26,30], denoting the importance of not considering all fats as detrimental.…”
Section: Discussionsupporting
confidence: 90%
“…However, considering SFA intake as a whole may be misleading because diverse food sources of SFA have shown different impact on CV outcomes and mortality risk [26e29]. The potential controversies are mainly explained by the macronutrient that is substituted for SFA [30,31]. Based on this knowledge acquired in nutritional research, the current 2015e2020 Dietary Guidelines for Americans (DGA) recommend limiting SFA intake to less than 10% of calories but they give almost no specific recommendation on limiting meat consumption [32].…”
Section: Introductionmentioning
confidence: 99%
“…Addition of trans fats to foods and impart a desirable taste and texture. Trans-fat intake associates with higher risk of CHD 7 . National food agencies are restricting the use of trans fats in foodstuffs.…”
Section: Risk Factor Modification and Altered Incidence Of Acute Cardmentioning
confidence: 97%
“…An increased dietary intake of saturated fatty acids is associated with increased risk of CVD and reversely, a decreased saturated fatty acids intake combined with an increased polyunsaturated and monounsaturated fatty acids intake but without increasing total dietary fat intake is associated with a reduced CVD risk [6][7][8][9]. N-3 and n-6 polyunsaturated fatty acids are inversely associated with CVD risk [10].…”
Section: Introductionmentioning
confidence: 99%