Dietary Fat Intake and Fecundability in 2 Preconception Cohort Studies

Wise, Lauren A.; Wesselink, Amelia K.; Tucker, Katherine L.; Saklani, Shilpa; Mikkelsen, Ellen M; Cueto, Heidi T; Riis, Anders H.; Trolle, Ellen; McKinnon, Craig J.; Hahn, Kristen A.; Rothman, Kenneth J.; Sørensen, Henrik Toft; Hatch, Elizabeth E.

doi:10.1093/aje/kwx204

Cited by 72 publications

(92 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Furthermore, trans fat intake was associated with reduced fecundability in a large North American preconception cohort (PRESTO study) (99). However, no such association was observed in a similar Danish preconception cohort (Snart Foraeldre study), where trans fat intake was low (99). u-3 PUFA and fecundity, ovulatory infertility, and ovarian aging.…”

Section: Fatty Acidsmentioning

confidence: 90%

Diet and female fertility: doctor, what should I eat?

Chiu

Chavarro

Souter

2018

Fertility and Sterility

View full text Add to dashboard Cite

Fecundity is the capacity to produce offspring. Identifying dietary factors that influence human fecundity is of major clinical and public health significance. This review focuses on the evidence from epidemiologic literature for the relationships between key nutritional factors and female reproductive potential. According to existing data, women trying to achieve pregnancy are encouraged to increase consumption of whole grains, omega-3 fatty acids, fish, and soy and to reduce consumption of trans fats and red meat. In addition, a daily multivitamin that contains folic acid before and during pregnancy may not only prevent birth defects, but also improve the chance of achieving and maintaining a pregnancy. In contrast, there is limited evidence supporting an association between vitamin D and human fecundity outcomes despite promising evidence from nonhuman studies. Questions for future research included the roles of other types of fat (especially omega-6 and monounsaturated fats) and protein (especially white meat and seafood) on female fertility; particular attention should also be paid to exposure to environmental contaminants in foods. Although much work remains, this review accrued best available evidence to provide practical dietary recommendations for women trying to conceive.

show abstract

Section: Fatty Acidsmentioning

confidence: 90%

Diet and female fertility: doctor, what should I eat?

Chiu

Chavarro

Souter

2018

Fertility and Sterility

View full text Add to dashboard Cite

show abstract

“…Standardized alimentary supplementation of omega-3-fatty acids before and during an in vitro fertilization therapy so far has not been subject of a well-designed randomized prospective study. Just few small, prospective cohort studies have examined the relationship between serum omega-3-fatty acid levels and IVF-success with conflicting results [16][17][18][19][20]. One of the first approaches to study the correlation of omega-3-fatty acid supplementation and the probability of a pregnancy is the PREPARE-trial by Kermack and co-workers [15], which has not been finished yet.…”

Section: Introductionmentioning

confidence: 99%

Effects of Periconceptual Omega-3-Fatty Acid Supplementation on in Vitro Fertilization Success and Miscarriage Rates in Patients of a German Fertility Centre

Bareksei¹,

Häfner²,

Pfeiffer³

et al. 2019

IJCEMS

View full text Add to dashboard Cite

Long-chain omega-3 fatty acids have been positively related with improvement of fertility in both women and men. Primary natural source of omega-3-fatty acids is seafood. As this also can bei the source of toxicants like f.e. lead, mercury and cadmium, reproductive benefits may be counteracted. Therefore, our approach was to supplement pharmaceutical grade omega-3-fatty acids in order to assess potential benefits of omega-3-fatty acids on modulation of IVFsuccess by dietary measures in a well-defined group of patients of a German Fertility Centre. A group of 52 IVF-patients with a history of at least two miscarriages or unsuccessful in vitro fertilization approaches received periconceptual omega-3-fatty acid supplementation for a time period of at least 3 weeks. The "historical" control group, consisting of 1109 patients without omega-3-fatty acid supplementation, was generated out of the Fertility Centre´s patient database. The same inclusion criteria (history of at least two miscarriages or unsuccessful in vitro fertilization approaches) were applied for both groups. Omega-3-fatty acid supplementation lead to significantly enhanced in vitro fertilization success rates as well as to reduction of miscarriage rates compared to patients of the control group. The results encourage to design further agematched, double-blinded prospective studies in order to verify a positive influence of dietary intervention and lifestyle modification on fertility rates.

show abstract

“…In a recent prospective cohort study, Gaskins et al (2018) demonstrated that, among couples trying to conceive naturally, those in which the men consumed a high level of fish oil had a higher fecundity rate with increased sexual drive and reduced time to pregnancy ; however, no data are available on sperm parameters before or at any time of the study, nor whether there was any male factor infertility. Similarly, recent data showed a positive association between a diet enriched with omega-3 PUFAs consumed by women (Wise et al, 2018), or by either or both partners , and natural fecundity and time to pregnancy among couples trying to conceive naturally; however, no randomized controlled trials have evaluated the effect of omega-3 PUFAs Hammiche et al, 2011, USA 235 Dietary intake of fatty acids by self-reported questionnaires over 4 weeks before cycle…”

Section: Discussionmentioning

confidence: 99%

“…In a recent study, Wise et al (2018) assessed the association between dietary fat consumption and fecundity or time to pregnancy among women participating in preconception cohort studies in Denmark (n = 1126) and in the USA (n = 1290). Women were included if they were trying to conceive for less than 6 months and had completed the specially designed food frequency intake online questionnaire.…”

Section: Omega-3 Pufas and Natural Fertilitymentioning

confidence: 99%

Omega-3 polyunsaturated fatty acids and IVF treatment

Lass¹,

Belluzzi

2019

Reproductive BioMedicine Online

View full text Add to dashboard Cite

Omega-3 polyunsaturated fatty acids (PUFAs) are essential fatty acids, derived mostly from fish oil, that have a significant anti-inflammatory effect. Data from animal studies support their role in the reproductive mechanism, and recent human studies suggest a positive effect on sperm quality and natural conception. Their general role in human fertility, and specifically in IVF treatment, however, is not clear. A few small, prospective cohort studies have examined the relationship between serum PUFAs and outcome measures and success in IVF, with conflicting results. Some have demonstrated a better chance of live birth with increased levels of serum omega-3 PUFAs, whereas others have failed to show such a correlation, and the reasons for such differences are not clear. Moreover, no welldesigned, published studies have assessing whether the administration of omega-3 PUFAs before IVF treatment can improve clinical pregnancy and live birth rates. The development of safe and well-tolerated pharmaceutical forms of the active omega-3 PUFAs, docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), mean that assessment of this question is now possible and future studies are warranted.

show abstract

Dietary Fat Intake and Fecundability in 2 Preconception Cohort Studies

Cited by 72 publications

References 54 publications

Diet and female fertility: doctor, what should I eat?

Diet and female fertility: doctor, what should I eat?

Effects of Periconceptual Omega-3-Fatty Acid Supplementation on in Vitro Fertilization Success and Miscarriage Rates in Patients of a German Fertility Centre

Omega-3 polyunsaturated fatty acids and IVF treatment

Contact Info

Product

Resources

About