Dietary fat composition and the metabolic syndrome

Panico, Salvatore

doi:10.1002/ejlt.200300902

Cited by 14 publications

(7 citation statements)

References 81 publications

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“…Studies in experimental animals have shown that prolonged elevated fat intakes potentially may lead to insulin resistance. Rodents appear to be particularly susceptible for developing insulin resistance in response to high‐saturated fat diets (35,36). Although chronically increased saturated fatty acids intakes are consistently associated with high insulin resistance, monounsaturated fatty acids and polyunsaturated fatty acid intake, without increasing total fat intake, seems to improve insulin sensitivity (36).…”

Section: Potential Long‐term Health Implicationsmentioning

confidence: 99%

Low‐carbohydrate diets: nutritional and physiological aspects

Adam-Perrot¹,

2006

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Recently, diets low in carbohydrate content have become a matter of international attention because of the WHO recommendations to reduce the overall consumption of sugars and rapidly digestible starches. One of the common metabolic changes assumed to take place when a person follows a low-carbohydrate diet is ketosis. Low-carbohydrate intakes result in a reduction of the circulating insulin level, which promotes high level of circulating fatty acids, used for oxidation and production of ketone bodies. It is assumed that when carbohydrate availability is reduced in short term to a significant amount, the body will be stimulated to maximize fat oxidation for energy needs. The currently available scientific literature shows that low-carbohydrate diets acutely induce a number of favourable effects, such as a rapid weight loss, decrease of fasting glucose and insulin levels, reduction of circulating triglyceride levels and improvement of blood pressure. On the other hand some less desirable immediate effects such as enhanced lean body mass loss, increased urinary calcium loss, increased plasma homocysteine levels, increased low-density lipoprotein-cholesterol have been reported. The long-term effect of the combination of these changes is at present not known. The role of prolonged elevated fat consumption along with low-carbohydrate diets should be addressed. However, these undesirable effects may be counteracted with consumption of a low-carbohydrate, high-protein, low-fat diet, because this type of diet has been shown to induce favourable effects on feelings of satiety and hunger, help preserve lean body mass, effectively reduce fat mass and beneficially impact on insulin sensitivity and on blood lipid status while supplying sufficient calcium for bone mass maintenance. The latter findings support the need to do more research on this type of hypocaloric low-carbohydrate diet.

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Section: Potential Long‐term Health Implicationsmentioning

confidence: 99%

Low‐carbohydrate diets: nutritional and physiological aspects

Adam-Perrot¹,

2006

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“…3 Overweight and obesity are also defined as abnormal or excessive fat accumulation triggered by disproportion in energy intake and expenditure. [4][5][6] In addition to this attenuation in adipogenesis and over expression of pancreatic lipase enzyme which plays a pivotal role in progression of obesity. 7 The literature review revealed that alteration in dietary habit and less physical exercises, too, increase the frequency of obesity and related disorders.…”

Section: Introductionmentioning

confidence: 99%

Antiobesity activity of Moringa oleifera leaves against high fat diet-induced obesity in rats

Nahar

Faisal

Iqbal

et al. 2016

Int J Basic Clin Pharmacol

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“…Nowadays Obesity has emerged as a major health problem and risk factor for various disorders worldwide [1]. Overweight and obesity are defined as abnormal or excessive fat accumulation triggered by disproportion in energy intake and expenditure [2][3][4]. In addition to this attenuation in adipogenesis and over expression of pancreatic lipase enzyme which plays a pivotal role in progression of obesity [5].…”

Section: Introductionmentioning

confidence: 99%

Antiobesity and Hypolipidemic Activity ofMoringa oleiferaLeaves against High Fat Diet-Induced Obesity in Rats

Bais

Singh

Sharma

2014

Advances in Biology

100

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In the present study, the methanolic extract ofMoringa oleiferaleaves (MEMOL) was evaluated for antiobesity activity in rats. The antiobesity potential of MEMOL was studied against high fat diet-induced obesity (HFD) in rats. In this study, chronic administration of HFD in rats produced hypercholesterolemia (116.2 ± 0.27 mg/dL), which led to an increase in the body weight (225 gr), total cholesterol, triglycerides (263.0 ± 4.69 mg/dL), and attenuation in the levels of HDL (34.51 ± 2.20 mg/dL) as well as changes in body temperature of animals. Treatment of obese rats with MEMOL for 49 days resulted in a significant (P<0.001) change in body weight, total cholesterol, triglycerides, and LDL level along with a significant (P<0.001) increase in body temperature as compared to the HFD-induced obesity. MEMOL treated rats also showed a significant decrease in the level of liver biomarkers, organ weight, and blood glucose level. Further, rats treated with MEMOL (200 mg and 400 mg/kg) show reduced atherogenic index (1.7 ± 0.6 and 0.87 ± 0.76). The results indicate that the rats treated withMoringa oleifera(MO) have significantly attenuated the body weight without any change in the feed intake and also elicited significant thermogenic effect and to act as hypolipidemic and thermogenic property in obesity related disorders.

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Dietary fat composition and the metabolic syndrome

Cited by 14 publications

References 81 publications

Low‐carbohydrate diets: nutritional and physiological aspects

Low‐carbohydrate diets: nutritional and physiological aspects

Antiobesity activity of Moringa oleifera leaves against high fat diet-induced obesity in rats

Antiobesity and Hypolipidemic Activity ofMoringa oleiferaLeaves against High Fat Diet-Induced Obesity in Rats

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