Dietary factors in rheumatic autoimmune diseases: a recipe for therapy?

Dahan, Shani; Segal‬‏, Yahel; Shoenfeld, Yehuda

doi:10.1038/nrrheum.2017.42

Cited by 55 publications

(50 citation statements)

References 158 publications

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“…An expression of these receptors promotes prolonged residence of macrophages in bloodstream and the development of foam cells due to increased receptor-mediated oxLDL uptake. A review summarizes the connection between dietary nutrients and immune function [35,60] and we elaborate on some of the mechanisms by which dietary lipids influence immune function at the cellular level.…”

Section: Fatty Acids Influence Lymphocyte Proliferation and Cytokine mentioning

confidence: 99%

Dietary Bioactive Fatty Acids as Modulators of Immune Function: Implications on Human Health

et al. 2019

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Diet is major modifiable risk factor for cardiovascular disease that can influence the immune status of the individual and contribute to persistent low-grade inflammation. In recent years, there has been an increased appreciation of the role of polyunsaturated fatty acids (PUFA) in improving immune function and reduction of systemic inflammation via the modulation of pattern recognition receptors (PRR) on immune cells. Extensive research on the use of bioactive lipids such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) and their metabolites have illustrated the importance of these pro-resolving lipid mediators in modulating signaling through PRRs. While their mechanism of action, bioavailability in the blood, and their efficacy for clinical use forms an active area of research, they are found widely administered as marine animal-based supplements like fish oil and krill oil to promote health. The focus of this review will be to discuss the effect of these bioactive fatty acids and their metabolites on immune cells and the resulting inflammatory response, with a brief discussion about modern methods for their analysis using mass spectrometry-based methods.

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Section: Fatty Acids Influence Lymphocyte Proliferation and Cytokine mentioning

confidence: 99%

Dietary Bioactive Fatty Acids as Modulators of Immune Function: Implications on Human Health

et al. 2019

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“…Bo Vahlquist (1909‐1978), a renowned pediatrician once said “In all mammalian species the reproductive cycle comprises both pregnancy and breast‐feeding: in the absence of latter, none of these species, man included, could have survived” . Diet is one of the most important environmental exposures in early life . Currently, the World Health Organization recommends that infants should be exclusively breastfed up to 6 months of age and continue with a partial pattern until the infant is at least 2 years old .…”

Section: Introductionmentioning

confidence: 99%

Breastfeeding and autoimmunity: Programing health from the beginning

Borba

Sharif

Shoenfeld

2017

American J Rep Immunol

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Breast milk is not only a completely adapted nutrition source for the newborn but also an impressive array of immune-active molecules that afford protection against infections and shape mucosal immune responses. Decisive imprinting events might be modulated during the first months of life with potential health long-term effects, enhancing the importance of breastfeeding as a major influence on the immune system correct development and modifying disease susceptibility. The aim of this review was to clarify the link between breastfeeding and autoimmune diseases, inquiring the related mechanisms, based on data available in the literature. Being breastfed was associated with a lower incidence of diabetes, celiac disease, multiple sclerosis and asthma, explained by the protection against early infections, anti-inflammatory properties, antigen-specific tolerance induction, and regulation of infant's microbiome. The protective role of human milk in idiopathic juvenile arthritis, rheumatoid arthritis, and inflammatory bowel diseases remains controversial. On the other hand, the breastfeeding mother faces a health-challenging period in life. High levels of prolactin may lead either to the development of autoimmune diseases in susceptible mothers or exacerbations of current immune-mediated disorders. These features raise the question if mothers with autoimmune diseases, mainly systemic lupus erythematosus, should avoid breastfeeding.

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“…The reason for this increase has been attributed partially to the hygiene hypothesis . However, there is also rising evidence that dietary factors contribute to the pathogenesis of several autoimmune diseases . In this regard, recent studies in the mouse have shown that animals fed a HSD are likely to develop more severe autoimmune manifestations …”

Section: Introductionmentioning

confidence: 99%

Increased salt exposure affects both lymphoid and myeloid effector functions, influencing innate‐associated disease but not T‐cell‐associated autoimmunity

et al. 2018

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High salt consumption has since long been associated with elevated blood pressure and cardiovascular disease. Recently, mouse studies suggested that a high dietary salt intake exacerbates the clinical manifestations of autoimmunity. Using naïve cells ex vivo after pre-exposure of mice to high salt intake, we showed that increased salt exposure affects the viability and effector functions of immune cells. CD4 T-cells evidenced a pro-inflammatory phenotype characterized by increased secretion of IFNγ and IL-17A, when exposed to high salt concentrations in vitro. Interestingly, this phenotype was associated with osmotic pressure, as replacing salt for d-mannitol resulted in similar observations. However, high salt intake did not alter the development of T-cell-dependent autoimmunity. Instead, recruitment of peritoneal macrophages was increased in mice pre-exposed to high salt concentrations. These cells had an increased production of both TNFα and IL-10, suggesting that salt stimulates expansion and differentiation of different subsets of macrophages. Moreover, mice pre-exposed to high salt intake developed exacerbated symptoms of colitis, when induced by dextran sulphate sodium. The aggravated colitis in salt-exposed animals was associated with a higher frequency of CD4 T-cells and CD11b CD64 macrophages producing TNFα. These phenotypes correlated with elevated titres of faecal IgA and higher lymphocytic cellularity in the colon, mesenteric lymph nodes and spleen. In conclusion, we report here that high salt intake affects both lymphoid and myeloid cells ex vivo. However, the effects of high salt intake in vivo seem less pronounced in terms of CD4 T-cell responses, whereas macrophage-dependent pathologies are significantly influenced.

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Dietary factors in rheumatic autoimmune diseases: a recipe for therapy?

Cited by 55 publications

References 158 publications

Dietary Bioactive Fatty Acids as Modulators of Immune Function: Implications on Human Health

Dietary Bioactive Fatty Acids as Modulators of Immune Function: Implications on Human Health

Breastfeeding and autoimmunity: Programing health from the beginning

Increased salt exposure affects both lymphoid and myeloid effector functions, influencing innate‐associated disease but not T‐cell‐associated autoimmunity

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