Dietary factors in oral leukoplakia and submucous fibrosis in a population‐based case control study in Gujarat, India

Pc, Gupta; Hébert, J.; Bhonsle, R. B.; Sinor, P. N.; Mehta, Hemali; Mehta, Fali S.

doi:10.1111/j.1601-0825.1998.tb00279.x

Cited by 68 publications

(38 citation statements)

References 46 publications

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“…Many of the OSF patients present with anemias and nutritional deficiencies (Maher et al 1997;Gupta et al 1998). It is not clear how these conditions are related to OSF, although it seems prudent to consider laboratory testing as a secondary objective measure, particularly if designing a medical intervention involving the use of micronutrients, vitamins, or nutritional supplements.…”

Section: Outcome Measuresmentioning

confidence: 99%

A systematic review of medical interventions for oral submucous fibrosis and future research opportunities

et al. 2011

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Oral submucous fibrosis (OSF) is a chronic, insidious disease caused by areca nut use, and is associated with both significant morbidity (including pain and reduced oral opening) and an increased risk for malignancy. This systematic review explored and updated the current medical (i.e., non-surgical) interventions available for the management of OSF. Of the 27 published medical interventions, there were four randomized controlled trials. The overall quality of these randomized controlled studies was assessed using the GRADE approach and significant limitations that challenged the conclusions were found. However, this review was valuable in terms of identifying opportunities to provide recommendations for future research, in terms of the populations to research, the types of interventions needed, the types of outcomes to be measured, the study designs needed, and the infrastructure required to conduct studies. The next step is to initiate a pathway for a low-cost research plan leading to the development of a brief protocol for future clinical trials in this field, with an emphasis on conducting studies in regions of the world where OSF is prevalent.

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Section: Outcome Measuresmentioning

confidence: 99%

A systematic review of medical interventions for oral submucous fibrosis and future research opportunities

et al. 2011

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“…Cohort studies have suggested a protective effect of fruits on bladder cancer (Riboli and Norat, 2003), while a very large cohort study did not find a protective effect of five or more servings of fruits and vegetables on total cancer risk (Hung et al, 2004). Both case-control and cohort studies show that high intake of fruits and vegetables are inversely associated with oral precancer (Gupta et al, 1998;Morse et al, 2000;Maserejian et al, 2006) and cancer (Gridley et al, 1990;Levi et al, 1998;Boeing et al, 2006;Pavia et al, 2006). Fruits show a stronger and more consistent inverse association with oral cancer; for vegetables, the strongest inverse association is seen for tomatoes (De Stefani et al, 2000).…”

Section: Carbohydrate Intakementioning

confidence: 99%

Nutrition and health: guidelines for dental practitioners

2009

Br Dent J

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Good nutrition is vital to overall health, and poor diet and a sedentary lifestyle are major causes of morbidity and mortality worldwide. Nutritional factors are implicated in many oral and systemic diseases and conditions, including obesity, hypertension, dyslipidemia, type II diabetes, cardiovascular disease, osteoporosis, dental caries and some cancers including oral cancers. This review focuses on the evidence for the relations between key nutritional factors and health. Energy intake is related to body weight and obesity, highlighting the importance of lower-energy diets and regular physical activity for body weight maintenance and for preventing obesity. Evidence is presented for the health benefits of high quality carbohydrates, such as whole grain products, and fruits and vegetables, in reducing the risk of cardiovascular disease and cancer. The adverse effects of sugar, sweetened beverages, and trans and saturated fats on several diseases including caries, diabetes and cardiovascular disease are described. The health benefits of unsaturated fats, antioxidants, B vitamins and vitamin D in cardiovascular disease, periodontitis, cancer, and other conditions are documented. Both benefits and harmful effects of dairy product intake on health are discussed. Based on the evidence, nutritional guidelines are provided, as well as key recommendations for preventing obesity. Dentists can play a critical role in motivating and enabling healthy food choices.

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“…Chronic areca nut chewing has been strongly linked to the development of oral submucous fibrosis (OSF) (Murti et al 1995;Warnakulasuriya et al 1997;Gupta et al 1998), a chronic progressive pre-cancerous condition characterised by fibrosis of the mucosal lining of the oral cavity and occasionally the upper digestive tract (Maher et al 1991). The oral fibrosis often progresses into the submucosal regions and the underlying muscle, leading to deposition of dense fibrous bands ) and consequently restricts the opening of the mouth (trismus), a hallmark of the condition.…”

Section: Introductionmentioning

confidence: 99%

Effect of areca nut on salivary copper concentration in chronic chewers

Raja¹,

Hazarey

Peters

et al. 2006

Biometals

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The chewing of areca nut is associated with the development of oral submucous fibrosis (OSF), a condition predominantly encountered in Asians indulging in the habit. The pathogenesis of this condition is however, unclear, though several mechanisms have been proposed. Copper has previously been implicated as a possible aetiological factor. In this study, total copper concentration was measured via atomic absorption spectrophotometry in whole mouth saliva of 15 volunteers who were regular chewers, before and after their habitual chew. An aliquot of the latter was also analysed for copper. Six non-chewing volunteers acted as controls. Salivary copper concentrations were corrected for protein content. Over 50% of the subjects had basal salivary copper concentration higher than the range seen in normal controls. All but two subjects demonstrated an increase in the salivary [Cu] following their habitual chew. Marked changes were seen in those with low basal salivary concentrations. These data indicate that soluble copper found in areca nut is released into the oral environment of habitual chewers. Its buccal absorption may contribute to the oral fibrosis in Asians who regularly chew this nut.

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Dietary factors in oral leukoplakia and submucous fibrosis in a population‐based case control study in Gujarat, India

Cited by 68 publications

References 46 publications

A systematic review of medical interventions for oral submucous fibrosis and future research opportunities

A systematic review of medical interventions for oral submucous fibrosis and future research opportunities

Nutrition and health: guidelines for dental practitioners

Effect of areca nut on salivary copper concentration in chronic chewers

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