Dietary factors in erectile dysfunction

Esposito, Katherine; Giugliano, Francesco; Sio, Marco De; Carleo, Diego; Palo, Carmen Di; D’Armiento, Massimo; Giugliano, Dario

doi:10.1038/sj.ijir.3901438

Cited by 52 publications

(36 citation statements)

References 34 publications

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“…The physiological rationales underlying this hypothesis are that: (a) healthy lifestyle factors are associated with maintenance of good erectile function in men; 17 (b) the metabolic syndrome associate with ED, endothelial dysfunction, and increased serum concentrations of vascular inflammatory markers; 11,18 and (c) dietary factors may be important in the development of ED. 19 Our results show that consumption of a Mediterranean-style diet in men with the metabolic syndrome and ED at baseline produced significant improvement of erectile and endothelial functions, together with a significant reduction of systemic vascular inflammation, as indicated by the reduced levels of CRP. As a whole, these findings suggest that a Mediterranean-style diet is a strategy for amelioration of vascular functions, including erectile function.…”

Section: Discussionmentioning

confidence: 63%

Mediterranean diet improves erectile function in subjects with the metabolic syndrome

et al. 2006

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Men with the metabolic syndrome demonstrate an increased prevalence of erectile dysfunction (ED). In the present study, we tested the effect of a Mediterranean-style diet on ED in men with the metabolic syndrome. Men were identified in our database of subjects participating in controlled trials evaluating the effect of lifestyle changes and were included if they had a diagnosis of ED associated with a diagnosis of metabolic syndrome, complete follow-up in the study trial, and intervention focused mainly on dietary changes. Sixty-five men with the metabolic syndrome met the inclusion/exclusion criteria; 35 out of them were assigned to the Mediterranean-style diet and 30 to the control diet. After 2 years, men on the Mediterranean diet consumed more fruits, vegetables, nuts, whole grain, and olive oil as compared with men on the control diet. Endothelial function score and inflammatory markers (C-reactive protein) improved in the intervention group, but remained stable in the control group. There were 13 men in the intervention group and two in the control group (P ¼ 0.015) that reported an IIEF score of 22 or higher. Mediterranean-style diet rich in whole grain, fruits, vegetables, legumes, walnut, and olive oil might be effective per se in reducing the prevalence of ED in men with the metabolic syndrome.

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Section: Discussionmentioning

confidence: 63%

Mediterranean diet improves erectile function in subjects with the metabolic syndrome

et al. 2006

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“…obesity, sedentary lifestyle, alcohol abuse) should be counseled [138,141,142]. Lifestyle change is associated with improved sexual function in about one third of obese men with ED [143]. Additionally, a case-control study investigated the relationship …”

Section: Discussionmentioning

confidence: 99%

Dyslipidemia as a Risk Factor for Erectile Dysfunction

Vrentzos¹,

Paraskevas²,

Mikhailidis

2007

CMC

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Erectile dysfunction (ED) is a common condition with a significant effect on quality of life. The prevalence of ED increases with age and other risk factors (hypertension, diabetes, smoking, coronary heart disease, dyslipidemia and depression). Nitric oxide (NO) activity is adversely affected, in penile and vascular tissue, by these risk factors. Endothelial dysfunction and a reduced generation or bioavailability of NO have emerged as major pathophysiological mechanisms in ED. Hyperlipidemia may impair erectile function by affecting endothelial and smooth muscle cells of the penis. Oxidized low-density lipoprotein is a causative factor for the impaired relaxation response of the corpus cavernosum. Elevated serum cholesterol and reduced high density lipoprotein cholesterol levels are associated with an increased risk of ED. It follows that treating dyslipidemia could have a beneficial effect on ED. Phosphodiesterase type 5 inhibitors are now considered as first line treatment for ED. There is evidence that statins improve responses to these drugs. ED is considered as a warning sign of silent or early vascular disease. The use of statins may be beneficial in these patients.

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“…Zinc was also found to improve sperm count, motility and morphology [21 ]. Observational and intervention studies also showed that dietary pattern such as the Mediterranean diet reduced the risk of erectile dysfunction in men [22,23]. In the intervention trial, the Mediterranean diet group did not differ from control diet group in total energy intake or macronutrient composition, but the Mediterranean diet group had a higher intake of fruits, vegetables, nuts and legumes [23].…”

Section: Dietary Factors and Fertilitymentioning

confidence: 94%

Dietary effects on fertility treatment and pregnancy outcomes

Lim

Noakes

Norman

2007

Current Opinion in Endocrinology, Diabetes &Amp; Obesity

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Body weight and specific dietary factors may affect fertility but evidence regarding dietary effects on fertility treatment outcomes is lacking. Research suggests that diets with a low glycemic load during pregnancy may reduce the risk of gestational diabetes or large-for-gestational-age births after adjusting for body mass index and total energy intake, but the effect of protein modification remains controversial. There is also lack of information on the impact of energy restriction during pregnancy on maternal and infant outcomes. Folate supplementation is recommended for prevention of birth defects but further research is required to determine the optimal dose to reduce the risks of multiple gestations. Further information on the upper limits of caffeine and alcohol intake during pregnancy would also be useful.

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Dietary factors in erectile dysfunction

Cited by 52 publications

References 34 publications

Mediterranean diet improves erectile function in subjects with the metabolic syndrome

Mediterranean diet improves erectile function in subjects with the metabolic syndrome

Dyslipidemia as a Risk Factor for Erectile Dysfunction

Dietary effects on fertility treatment and pregnancy outcomes

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