Dietary factors and survival from breast cancer

Abstract

The association between self-reported intake of various dietary factors at diagnosis and survival from breast cancer was studied in a population-based cohort of breast cancer patients in Adelaide, South Australia. These patients had been recruited between 1982 and 1984 into a case-control study of diet and incident breast cancer. Of the 451 patients recruited originally, 412 were followed for a median interval of 5.5 years. There were decreases in the risk of death from breast cancer ranging from 25 to 40% at all levels of energy and protein intake above the baseline, whereas for fat intake there was a 40% increase in risk at the uppermost quintile level. There was also some reduction in risk at the upper levels of intake of beta-carotene and vitamin C. However, there were no dose-dependent variations in risk of death by level of intake for any of the dietary factors studied, and most of the variation in risk that was observed was relatively insubstantial.

Alcohol Consumption and Breast Cancer Survival: A Metaanalysis of Cohort Studies

“…After reading full-texts, we excluded studies that were not cohort studies (n =61) and not about survival (n=61). Finally, 25 cohort studies (Hebert et al, 1989;Ewertz et al, 1991;Rohan et al, 1993;Fuchs et al, 1995;Zhang et al, 1995;Thun et al, 1997;Holmes et al, 1999;Saxe et al, 1999;Jain et al, 2000;McDonald et al, 2002;Borugian et al, 2004;Barnett et al, 2008;Dal Maso et al, 2008;Reding et al, 2008;Franceschi et al, 2009;Flatt et al, 2010;Hellmann et al, 2010;Kwan et al, 2010;Allemani et al, 2011;Beasley et al, 2011;Breslow et al, 2011;Harris et al, 2012;Vrieling et al, 2012;Holm et al, 2013;Kwan et al, 2013;Newcomb et al, 2013) (patients) were included ( Figure 1). …”

“…And the meta-analysis results showed prediagnostic alcohol consumption was not associated with increased breast cancer mortality (HR1.05, 95%CI 0.93 1.19, I 2 =36%) ( Figure 2) and recurrence (HR1.24, 95%CI 0.89 1.73, I 2 =31%) (Figure 3). 12 studies (Ewertz et al, 1991;Rohan et al, 1993;Fuchs et al, 1995;Holmes et al, 1999;McDonald et al, 2002;Borugian et al, 2004;Franceschi et al, 2009;Flatt et al, 2010;Kwan et al, 2010;Beasley et al, 2011;Breslow et al, 2011;Kwan et al, 2013) evaluated the relationship of post-diagnostic alcohol consumption with breast cancer mortality and two studies (Kwan et al, 2010;Kwan et al, 2013) evaluated the relationship of post-diagnostic alcohol consumption with breast cancer recurrence. And the meta-analysis results showed post-diagnostic alcohol consumption was not associated with increased breast cancer mortality (HR1.08, 95%CI 0.94 1.25, I 2 =30%) ( Figure 2) and recurrence (HR1.17, 95%CI 0.80 1.73, I 2 =0%) (Figure 3).…”

“…Both meta-analysis and pooled study showed that (Poli et al, 2012;Bagnardi et al, 2013) alcohol consumption increases risk of breast cancer. However, the information on whether alcohol consumption is related to breast cancer survival is mixed (Hebert et al, 1989;Ewertz et al, 1991;Rohan et al, 1993;Fuchs et al, 1995;Zhang et al, 1995;Thun et al, 1997;Holmes et al, 1999;Saxe et al, 1999;Jain et al, 2000;McDonald et al, 2002;Borugian et al, 2004;Barnett et al, 2008;Reding et al, 2008;Franceschi et al, 2009;Flatt et al, 2010;Hellmann et al, 2010;Kwan et al, 2010;Allemani et al, 2011;Beasley et al, 2011;Breslow et al, 2011;Harris et al, 2012;Vrieling et al, 2012;Holm et al, 2013; Newcomb et al, 2013). Some studies reported that alcohol consumption was associated with reduced breast cancer mortality (Barnett et al, 2008;Reding et al, 2008;Flatt et al, 2010), while other studies revealed that alcohol consumption was associated with increased breast cancer mortality (Hebert et al, 1989;Fuchs et al, 1995;Jain et al, 2000;McDonald et al, 2002;Allemani et al, 2011;Vrieling et al, 2012).…”

“…Some studies reported that alcohol consumption was associated with reduced breast cancer mortality (Barnett et al, 2008;Reding et al, 2008;Flatt et al, 2010), while other studies revealed that alcohol consumption was associated with increased breast cancer mortality (Hebert et al, 1989;Fuchs et al, 1995;Jain et al, 2000;McDonald et al, 2002;Allemani et al, 2011;Vrieling et al, 2012). Even though, most studies found no relationship between alcohol consumption and breast cancer mortality (Ewertz et al, 1991;Rohan et al, 1993;Zhang et al, 1995;Thun et al, 1997;Holmes et al, 1999;Saxe et al, 1999;Borugian et al, 2004;Franceschi et al, 2009;Hellmann et al, 2010;Kwan et al, 2010;Beasley et al, 2011;Breslow et al, 2011;Harris et al, 2012;Holm et al, 2013;Kwan et al, 2013;Newcomb et al, 2013). For the association of alcohol consumption with breast cancer recurrence, available evidence was also conflicted (Hebert et al, 1989;Saxe et al, 1999;Kwan et al, 2010;Holm et al, 2013;Kwan et al, 2013).…”

Lifestyle changes and breast cancer prognosis: a review

“…The association between dietary fat intake and reduced survival has been confirmed in both postmenopausal and premenopausal breast cancer patients [47][48][49][50][51]. Interim results of the WINS study suggest a benefit of dietary fat reduction on relapse-free survival.…”