Dietary exposure to perfluoroalkyl acids for the Swedish population in 1999, 2005 and 2010

Vestergren, Robin; Berger, Urs; Glynn, Anders; Cousins, Ian T.

doi:10.1016/j.envint.2012.08.016

Cited by 178 publications

(134 citation statements)

References 64 publications

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“…6). No significant temporal trends for PFOS were observed in only 6 datasets of human samples [89,102,115,121,143], and two datasets of dietary items [99,142], but in each case the power to detect a trend was low. Overall, the declining trends for PFOS generally coincide with the timing of the 3M Co. phase out by 2002.…”

Section: Pfos Change Point Analysismentioning

confidence: 99%

“…Similarly, PFOS in total dietary intake for Swedes showed no statistically significant temporal trend. Although dietary intake was estimated to be lower after the phase-out [142], statistical power was low to detect a trend in this dataset.…”

Section: Pfos Change Point Analysismentioning

confidence: 99%

“…In Sweden, where all adequately powered human temporal trend studies of PFOS showed a decline, it was useful to compare with trends for important Swedish dietary items [99,142]. Nationally or regionally representative archived samples of hen eggs and farmed rainbow trout muscle showed significant and rapid decreasing trends between 1999 and 2010.…”

Section: Pfos Change Point Analysismentioning

confidence: 99%

See 2 more Smart Citations

What is the effect of phasing out long-chain per- and polyfluoroalkyl substances on the concentrations of perfluoroalkyl acids and their precursors in the environment? A systematic review

Land¹,

Wit²,

Bignert³

et al. 2018

Environ Evid

Self Cite

151

115

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Background: There is a concern that continued emissions of man-made per-and polyfluoroalkyl substances (PFASs) may cause environmental and human health effects. Now widespread in human populations and in the environment, several PFASs are also present in remote regions of the world, but the environmental transport and fate of PFASs are not well understood. Phasing out the manufacture of some types of PFASs started in 2000 and further regulatory and voluntary actions have followed. The objective of this review is to understand the effects of these actions on global scale PFAS concentrations.Methods: Searches for primary research studies reporting on temporal variations of PFAS concentrations were performed in bibliographic databases, on the internet, through stakeholder contacts and in review bibliographies. No time, document type, language or geographical constraints were applied in the searches. Relevant subjects included human and environmental samples. Two authors screened all retrieved articles. Dual screening of 10% of the articles was performed at title/abstract and full-text levels by all authors. Kappa tests were used to test consistency. Relevant articles were critically appraised by four reviewers, with double checking of 20% of the articles by a second reviewer. Meta-analysis of included temporal trends was considered but judged to not be appropriate. The trends were therefore discussed in a narrative synthesis.

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Section: Pfos Change Point Analysismentioning

confidence: 99%

Section: Pfos Change Point Analysismentioning

confidence: 99%

Section: Pfos Change Point Analysismentioning

confidence: 99%

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What is the effect of phasing out long-chain per- and polyfluoroalkyl substances on the concentrations of perfluoroalkyl acids and their precursors in the environment? A systematic review

Land¹,

Wit²,

Bignert³

et al. 2018

Environ Evid

Self Cite

151

115

View full text Add to dashboard Cite

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“…11 For shortchain PFCAs (C n F 2n+1 COOH, n < 7) and PFSAs (C n F 2n+1 SO 3 H, n < 6), on the other hand, the lower bioaccumulation potential 4 indicates that a lower exposure via the diet compared to long-chain homologues is to be expected. 15 However, little is known about the human exposure, accumulation, and elimination kinetics of shortchain PFAS replacements. 16−19 The pervasive exposure to PFASs has raised concerns regarding long-term effects in humans.…”

Section: ■ Introductionmentioning

confidence: 99%

“…13,14 The relative importance of dietary intake compared to other exposure pathways may also vary for the different PFAS homologues. 15 Consumption of fish and shellfish is a major determinant of internal exposure to PFOS and long-chain PFCAs. 11 For shortchain PFCAs (C n F 2n+1 COOH, n < 7) and PFSAs (C n F 2n+1 SO 3 H, n < 6), on the other hand, the lower bioaccumulation potential 4 indicates that a lower exposure via the diet compared to long-chain homologues is to be expected.…”

Section: ■ Introductionmentioning

confidence: 99%

Highly Elevated Serum Concentrations of Perfluoroalkyl Substances in Fishery Employees from Tangxun Lake, China

Zhou

Shi

Vestergren

et al. 2014

Environ. Sci. Technol.

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143

117

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Increasing production and use of per-and polyfluoroalkyl substances (PFASs) has been reported from China, and a few studies have shown there are subpopulations in China with high and increasing exposure to these chemicals. In this paper, we present a comprehensive exposure assessment of PFASs in fishery employees from Tangxun Lake, China. Exceptionally high serum concentrations of C4 to C12 PFASs were observed in fishery employees (n = 39, median perfluorooctanesulfonic acid (PFOS) 10 400 ng/mL) compared to a reference group from the same city (n = 9, median PFOS 18.7 ng/mL). On the basis of the comparison of different exposure pathways, it was concluded that contaminated fish from Tangxun Lake was the primary source of PFAS exposure to fishery employees, and there was a positive association between serum PFAS concentrations and time of employment in the fishery. PFOS isomer profiles in fishery employees showed a significantly higher proportion of linear PFOS (78.4%) compared to the background-exposed reference group (66.8%), reflecting the highly linear PFOS isomer profile (>90%) of lake fish. Median renal clearance rates (CL renal ) of C4 to C10 perfluoroalkyl carboxylic acids (PFCAs) and perfluoroalkanesulfonic acids (PFSAs) ranged from 0.020 to 16.5 mL/day/kg and 0.013 to 9.43 mL/day/kg, respectively. PFCAs with less than eight perfluoroalkyl carbons were primarily eliminated via urine, whereas other routes of excretion may have contributed to the elimination for long-chain PFCAs and PFSAs. Calculated daily PFOS exposures of fishery employees significantly exceeded tolerable daily intake limits, but clinical blood chemistry parameters were mostly within normal reference ranges. However, additional epidemiological studies are needed to address potential associations between PFAS exposure and health effects in the Tangxun Lake area.

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Short‐Chain Per/Polyfluoroalkyl Acids (C7 and Below)

Lasee,

Dourson,

Onyema

2024

Patty's Toxicology

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This chapter is about a series of short‐chain per‐ and polyfluoroalkyl substances (PFAS). In the past, PFAS were described as fluorinated fatty acids or sulfonates. The overall structure of PFAS is a carbon chain with fluorine atoms substituting for hydrogen atoms. The resulting chemicals are chemically stable, water and oil resistant, and useful for many industrial applications, such as in the formation of polymers. The most notorious in this group are the fluorinated fatty acids (carboxylates) or sulfonates. In biological systems, these chemicals are generally well‐absorbed by the oral route and resistant to metabolism but also have the unusual property of having drastically different elimination kinetics between mammalian species. The available literature on this group of PFAS (C7 and below) is modest. This chapter will not attempt to review all this literature. Rather, human studies will be emphasized. Since human studies often suggest associations between PFAS exposure and health outcomes, these studies will be followed by definitive experimental animal studies that give insights into the human evidence. Afterward, a summary of attempts to estimate potential human risk by various international agencies will be described. What will become obvious, however, is that the overall uncertainty in the database of some of these chemicals has led to widely divergent risk assessment positions that need to be resolved. Risk management decisions on specific members of this class of chemistries are seen to be premature without such scientific resolution.

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Dietary exposure to perfluoroalkyl acids for the Swedish population in 1999, 2005 and 2010

Cited by 178 publications

References 64 publications

What is the effect of phasing out long-chain per- and polyfluoroalkyl substances on the concentrations of perfluoroalkyl acids and their precursors in the environment? A systematic review

What is the effect of phasing out long-chain per- and polyfluoroalkyl substances on the concentrations of perfluoroalkyl acids and their precursors in the environment? A systematic review

Highly Elevated Serum Concentrations of Perfluoroalkyl Substances in Fishery Employees from Tangxun Lake, China

Short‐Chain Per/Polyfluoroalkyl Acids (C7 and Below)

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