Dietary exposure to perfluoroalkyl acids of specific French adult sub-populations: High seafood consumers, high freshwater fish consumers and pregnant women

Yamada, Ami; Bemrah, Nawel; Veyrand, Bruno; Pollono, Charles; Merlo, Mathilde; Desvignes, Virginie; Sirot, Véronique; Marchand, Philippe; Berrébi, Alain; Cariou, Ronan; Antignac, Jean‐Philippe; Bizec, Bruno Le; Leblanc, Jean-Charles

doi:10.1016/j.scitotenv.2014.01.089

Cited by 29 publications

(20 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Results utilizing a German cohort of 354 men, women, and children showed declines from baseline serum PFOA concentrations of 10–20% per year after filtration of drinking water [ 54 ]. However, these apparent contradictions probably reflect differences in sources of drinking water, whether bottled, well-water, or from rivers [ 57 , 63 ], and possibly also additional sources of PFAS exposure inherent in lifestyle choices [ 55 , 64 , 65 , 66 ] which the population may favor. In fact, one of the more intriguing observations emerging from the West Virginia/Ohio Valley cohort study was the significant effect of homegrown vegetable consumption on the apparent half-life of PFOA [ 57 ].…”

Section: Exposure Sources and Concentrations In The Populationmentioning

confidence: 99%

“…The primary exposure source for the general population, apart from drinking water, is diet [ 55 , 64 , 65 ] and the inhalation of PFAS-contaminated indoor air and dust (from furnishings) [ 66 ]. PFAS has been detected in 100% of people tested [ 67 , 68 , 69 , 70 ], with the exposure of Americans to PFAS ranging from an average of 0.9 ng/mL to over 100 ng/mL.…”

Section: Exposure Sources and Concentrations In The Populationmentioning

confidence: 99%

See 1 more Smart Citation

Perfluoroalkyl Chemicals and Male Reproductive Health: Do PFOA and PFOS Increase Risk for Male Infertility?

Tarapore

Ouyang

2021

IJERPH

View full text Add to dashboard Cite

Poly- and perfluoroalkyl substances (PFAS) are manmade synthetic chemicals which have been in existence for over 70 years. Though they are currently being phased out, their persistence in the environment is widespread. There is increasing evidence linking PFAS exposure to health effects, an issue of concern since PFAS such as perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) bioaccumulate in humans, with a half-life of years. Many epidemiological studies suggest that, worldwide, semen quality has decreased over the past several decades. One of the most worrying effects of PFOS and PFOA is their associations with lower testosterone levels, similar to clinical observations in infertile men. This review thus focuses on PFOS/PFOA-associated effects on male reproductive health. The sources of PFAS in drinking water are listed. The current epidemiological studies linking increased exposure to PFAS with lowered testosterone and semen quality, and evidence from rodent studies supporting their function as endocrine disruptors on the reproductive system, exhibiting non-monotonic dose responses, are noted. Finally, their mechanisms of action and possible toxic effects on the Leydig, Sertoli, and germ cells are discussed. Future research efforts must consider utilizing better human model systems for exposure, using more accurate PFAS exposure susceptibility windows, and improvements in statistical modeling of data to account for the endocrine disruptor properties of PFAS.

show abstract

Section: Exposure Sources and Concentrations In The Populationmentioning

confidence: 99%

Section: Exposure Sources and Concentrations In The Populationmentioning

confidence: 99%

Perfluoroalkyl Chemicals and Male Reproductive Health: Do PFOA and PFOS Increase Risk for Male Infertility?

Tarapore

Ouyang

2021

IJERPH

View full text Add to dashboard Cite

show abstract

“…It was also confirmed that fish, shellfish, meat, and other products of animal origin such as giblets are major contributors of PFAAs in the human diet [137]. Studies conducted by Yamada supported the thesis that fish and seafood are highly contaminated by PFAAs [138,139]. Freshwater fish consumers were the most exposed to PFOS at a level of 7.5 ng•kg −1 •bw•day −1 , and to a lesser extent to PFUnDA, PFDA, and PFHpS (perfluoroheptanesulfonic acid), whilst seafood consumers were the most exposed to PFOA (1.2 ng•kg −1 •bw•day −1 ), followed by PFNA and PFHxS.…”

Section: Dietary Intake Of Pfaasmentioning

confidence: 89%

A Review of Perfluoroalkyl Acids (PFAAs) in terms of Sources, Applications, Human Exposure, Dietary Intake, Toxicity, Legal Regulation, and Methods of Determination

Sznajder‐Katarzyńska

Surma

Cieślik

2019

Journal of Chemistry

102

View full text Add to dashboard Cite

Per- and polyfluoroalkyl substances (PFASs) are widely distributed across the world and are expected to be of concern to human health and the environment. The review focuses on perfluoroalkyl acids (PFAAs) and, in particular, on the most frequently discussed perfluoroalkyl carboxylic acids (PFCAs) and perfluoroalkane sulfonic acids (PFSAs). In this study, some basic information concerning PFASs is reviewed, focusing mainly on PFAAs (perfluoroalkyl acids). We have made efforts to systemize their division into groups according to chemical structure, describe their basic physicochemical properties, characterize production technologies, and determine potential human exposure routes with particular reference to oral exposure. A variety of possible toxicological effects to human health are also discussed. In response to increasing public concern about the toxicity of PFAAs, an evaluation of dietary intake has been undertaken for two of the most commonly known PFAAs: perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS). As summarized in this study, PFAAs levels need further assessment due to the science-based TWI standards laid down by the EFSA’s CONTAM Panel regarding the risk to human health posed by the presence of perfluorooctane sulfonic acid and perfluorooctanoic acid in food (tolerable weekly intakes of PFOA and PFOS set up to 6 ng·kg−1·bw·week−1 and 13 ng·kg−1·bw·week−1, respectively). Current legislation, relevant legislation on PFAAs levels in food, and the most popular methods of analysis in food matrices are described.

show abstract

“…The first was from water drinking, which is considered to be one of the most important routes of PFAS exposure for people in daily life . Besides, aquatic product consumption cannot be neglected because fish may have high bioaccumulation factors (BAFs), and consumption of fish may contribute to PFAS accumulation in the human body .…”

Section: Methodsmentioning

confidence: 99%

A new method to quantify the health risks from sources of perfluoroalkyl substances, combined with positive matrix factorization and risk assessment models

Shi

Guo

et al. 2017

Enviro Toxic and Chemistry

View full text Add to dashboard Cite

A hybrid model based on the positive matrix factorization (PMF) model and the health risk assessment model for assessing risks associated with sources of perfluoroalkyl substances (PFASs) in water was established and applied at Dianchi Lake to test its applicability. The new method contains 2 stages: 1) the sources of PFASs were apportioned by the PMF model and 2) the contribution of health risks from each source was calculated by the new hybrid model. Two factors were extracted by PMF, with factor 1 identified as aqueous fire-fighting foams source and factor 2 as fluoropolymer manufacturing and processing and perfluorooctanoic acid production source. The health risk of PFASs in the water assessed by the health risk assessment model was 9.54 Â 10 À7 a À1 on average, showing no obvious adverse effects to human health. The 2 sources' risks estimated by the new hybrid model ranged from 2.95 Â 10 À10 to 6.60 Â 10 À6 a À1 and from 1.64 Â 10 À7 to 1.62 Â 10 À6 a À1 , respectively. The new hybrid model can provide useful information on the health risks of PFAS sources, which is helpful for pollution control and environmental management.

show abstract

Dietary exposure to perfluoroalkyl acids of specific French adult sub-populations: High seafood consumers, high freshwater fish consumers and pregnant women

Cited by 29 publications

References 23 publications

Perfluoroalkyl Chemicals and Male Reproductive Health: Do PFOA and PFOS Increase Risk for Male Infertility?

Perfluoroalkyl Chemicals and Male Reproductive Health: Do PFOA and PFOS Increase Risk for Male Infertility?

A Review of Perfluoroalkyl Acids (PFAAs) in terms of Sources, Applications, Human Exposure, Dietary Intake, Toxicity, Legal Regulation, and Methods of Determination

A new method to quantify the health risks from sources of perfluoroalkyl substances, combined with positive matrix factorization and risk assessment models

Contact Info

Product

Resources

About