Dietary exposure to cadmium and health risk assessment in children – Results of the French infant total diet study

Jean, Julien; Sirot, Véronique; Hulin, Marion; Calvez, Emilie Le; Zinck, Julie; Noël, Laurent; Vasseur, Paule; Nesslany, Fabrice; Gorecki, Sébastien; Guérin, Thierry; Rivière, Gilles

doi:10.1016/j.fct.2018.03.031

Cited by 66 publications

(18 citation statements)

References 22 publications

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“…Regarding the main food contributors, these results are similar to a previous study in the United States where the top Cd contributors to children's diet at 10-11 years old were milk, lettuce, and cookies [28]. The TWIs are in line with a study in France that observed that diets of 5-6-year-old children exceeded the Cd TWI by 12-15% [12], while diets of 1 to 3-year-old and 6-year-old Finnish children exceeded the TWI by 88% and 64%, respectively [13].…”

Section: Discussionsupporting

confidence: 89%

“…Regarding dietary Cd exposure, previous studies have shown elevated tolerable weekly intakes (TWI = 2.5 µg/kg body weight) in children, wherein regularly consumed food items were an important source of Cd [12,13]. A study in Uruguayan children found that Cd levels increased with age [14], and notably, a recent study in Mexican children reported an association between dietary Cd intake and urinary Cd [15].…”

Section: Introductionmentioning

confidence: 99%

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Early-Life Dietary Cadmium Exposure and Kidney Function in 9-Year-Old Children from the PROGRESS Cohort

Rodríguez-López

Tamayo‐Ortiz

Ariza

et al. 2020

Toxics

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Cadmium (Cd) is a toxic metal associated with adverse health effects, including kidney injury or disease. The aims of this study were to estimate dietary Cd exposure during childhood, and to evaluate the association of early-life dietary Cd with biomarkers of glomerular kidney function in 9-year-old Mexican children. Our study included 601 children from the Programming Research in Obesity, Growth, Environment and Social Stressors (PROGRESS) cohort with up to five follow-up food frequency questionnaires from 1 to 9 years of age; and 480 children with measures of serum creatinine, cystatin C, and blood nitrogen urea (BUN), as well as 9-year-old estimated glomerular filtration rate. Dietary Cd was estimated through food composition tables. Multiple linear regression models were used to analyze the association between 1 and 9 years, cumulative dietary Cd, and each kidney parameter. Dietary Cd exposure increased with age and exceeded the tolerable weekly intake (TWI = 2.5 µg/kg body weight) by 16–64% at all ages. Early-life dietary Cd exposure was above the TWI and we observed inverse associations between dietary Cd exposure and kidney function parameters. Additional studies are needed to assess kidney function trajectories through adolescence. Identifying preventable risk factors including environmental exposures in early life can contribute to decreasing the incidence of adult kidney disease.

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Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Early-Life Dietary Cadmium Exposure and Kidney Function in 9-Year-Old Children from the PROGRESS Cohort

Rodríguez-López

Tamayo‐Ortiz

Ariza

et al. 2020

Toxics

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“…Cadmium has toxic effects on the renal, skeletal and respiratory systems, and can cause impaired calcium metabolism, osteomalacia and osteoporosis, and is classified as a human carcinogenic agent [39]. Although cadmium is present in small amounts in the environment, it can travel long distances to urban areas with large populations in a variety of ways, the consumption of contaminated foods being the main route [39,40]. Cadmium in soil and water is absorbed by agricultural products and aquatic organisms, and accumulate in the food chains [39].…”

Section: Discussionmentioning

confidence: 99%

Lead and Cadmium Contaminations in Fruits and Vegetables, and Arsenic in Rice: A Cross Sectional Study on Risk Assessment in Iran

Tajik

Alimoradian

Shamsi

et al. 2021

IJT

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Background: High levels of heavy metals in food are general concerns including carcinogenic effects. According to studies, the accumulation of heavy metals in crops and consumption of these products in diet, has led to serious health concerns. This study investigated the concentrations of lead and cadmium in popular agricultural products. Methods: In this descriptive study, some fresh agricultural products (leafy vegetables, tubers, cucurbits and seeds) were collected in the winter and summer. The samples were transferred to the laboratory and stored in a cold room. After the preparation of the samples, the lead and cadmium contents were determined by atomic absorption spectrometry. The data were analyzed statistically on SPSS v. 26 software. Results: The average concentrations of lead and cadmium in the winter was 37.23±4.7 and 34.77±0.5 while they were 44.12±0.02 and 56.83±0.01 μg/g in the summer. The highest amount of led content was reported in spinach at an average of 71.25 μg/g and the lowest content was found in watermelon at 30.67 μg/g. We observed a significant rise in the concentrations of the pollutants in leafy vegetables during the summer, which was also linked to the farms’ locations (P<0.05). Conclusion: The results showed that the highest amount of lead accumulation was found in leafy vegetables and that of the cadmium was at permissible levels in all produces as recommended by WHO. The risk of non-cancerous diseases was also low. Future studied are warranted to assess the risk of heavy metal toxicity in people, especially in children, the elderly and pregnant women.

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“…Los resultados demostraron que la exposición a Cd 2 + de 5 a 25 µg/mL aumentó significativamente la inviabilidad de los leucocitos, así como el daño en el ADN, que era dependiente de la dosis. Los Introduction Cadmium (Cd) is a heavy metal belonging to class II-B of the periodic table [1] that, even at low concentrations, has toxic effects [2,3]. In addition, Cd is a widely distributed pollutant in several sources as industrial waste, plastics and odontologic materials [2], cigarette smoke [4], forest fires [3], pigments [5], and fertilizers [6] and thus causes food and water contamination [7,8].…”

Section: Introductionmentioning

confidence: 99%

CdCl2 has zero-order kinetic cellular influx and induces cytotoxicity and genotoxicity at low concentrations in human leukocytes in vitro

Santos

Serpa

Silva

et al. 2019

Rev. Colomb. Cienc. Quím. Farm.

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Cadmium (Cd2+) is a nonessential heavy metal that possesses a high capacity of bioaccumulation and exhibits toxic characteristics even at low concentrations. This study evaluated the genotoxicity and cytotoxicity in human leukocytes in vitro after exposure to a lower range of Cd2+concentration (1-25 μg/mL) using an unprecedented strategy by correlating between intracellular Cd2+ levels after exposure and cellular damage. Results demonstrated that Cd2+exposure from 5 to 25 μg/mL significantly increased the unviability of leukocytes, as well as the DNA damage, which was dose-dependent. The intracellular Cd2+ levels in leukocytes ranged from 9.85 to 94.38 pg/cell, and cytotoxicity and genotoxicity were induced at a concentration of 24.22 pg/cell. The relationship between exposure concentration and intracellular Cd2+ levels suggests that its influx occurs in human leukocytes under zeroorder kinetics.

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Dietary exposure to cadmium and health risk assessment in children – Results of the French infant total diet study

Cited by 66 publications

References 22 publications

Early-Life Dietary Cadmium Exposure and Kidney Function in 9-Year-Old Children from the PROGRESS Cohort

Early-Life Dietary Cadmium Exposure and Kidney Function in 9-Year-Old Children from the PROGRESS Cohort

Lead and Cadmium Contaminations in Fruits and Vegetables, and Arsenic in Rice: A Cross Sectional Study on Risk Assessment in Iran

CdCl2 has zero-order kinetic cellular influx and induces cytotoxicity and genotoxicity at low concentrations in human leukocytes in vitro

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