Dietary exposure of mink (<i>Mustela vison</i>) to fish from the upper Hudson River, New York, USA: Effects on reproduction and offspring growth and mortality

Bursian, Steven J.; Kern, John C.; Remington, Richard; Link, Jane E.; Fitzgerald, Scott D.

doi:10.1002/etc.2110

Cited by 24 publications

(36 citation statements)

References 28 publications

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“…The model predicted a first litter size of 5.6 kits, fitting very well within the general range observed in mink (3–9) and more specifically the average of 5–6 kits seen in the toxicology literature232627. This model fit was achieved using a scaled functional response during reproduction ( f R ) of 2.52; in other words, this provided two and half times more assimilated mass to the 1-κ branch, or an additional 10 g/day of mass flux.…”

Section: Resultssupporting

confidence: 73%

“…While decreased feeding/assimilation as well as increased somatic maintenance costs captured PCB-induced growth retardation for the first 42 days of the mink lifetime, these pMoA resulted in long lasting and severe/fatal effects on growth and adult body weight that were not observed in the data. Though effects on early growth are documented in many studies232627, little evidence exists to suggest these continue so drastically into adulthood as predicted in the models for these pMoA. Furthermore, due to the interactions inherent in the model, the severe reductions in body size caused drastic reductions in reproduction rates that were not seen in the observed data (Fig.…”

Section: Resultsmentioning

confidence: 87%

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Using energy budgets to combine ecology and toxicology in a mammalian sentinel species

Desforges

Sonne

Dietz

2017

Sci Rep

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Process-driven modelling approaches can resolve many of the shortcomings of traditional descriptive and non-mechanistic toxicology. We developed a simple dynamic energy budget (DEB) model for the mink (Mustela vison), a sentinel species in mammalian toxicology, which coupled animal physiology, ecology and toxicology, in order to mechanistically investigate the accumulation and adverse effects of lifelong dietary exposure to persistent environmental toxicants, most notably polychlorinated biphenyls (PCBs). Our novel mammalian DEB model accurately predicted, based on energy allocations to the interconnected metabolic processes of growth, development, maintenance and reproduction, lifelong patterns in mink growth, reproductive performance and dietary accumulation of PCBs as reported in the literature. Our model results were consistent with empirical data from captive and free-ranging studies in mink and other wildlife and suggest that PCB exposure can have significant population-level impacts resulting from targeted effects on fetal toxicity, kit mortality and growth and development. Our approach provides a simple and cross-species framework to explore the mechanistic interactions of physiological processes and ecotoxicology, thus allowing for a deeper understanding and interpretation of stressor-induced adverse effects at all levels of biological organization.

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Section: Resultssupporting

confidence: 73%

Section: Resultsmentioning

confidence: 87%

Using energy budgets to combine ecology and toxicology in a mammalian sentinel species

Desforges

Sonne

Dietz

2017

Sci Rep

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“…The reproduction of farmed animals that are higher up in the food chain, such as the American mink, could potentially be affected by diets high in fish from polluted waters. Indeed, organochlorines in polluted fish have been seen to cause decreased litter size and increased offspring mortality in mink (Aulerich and Ringer 1977; Bursian et al 2013). …”

Section: Endocrine Disruption and Reproduction In Farm Animals – Clinmentioning

confidence: 99%

Endocrine Disruptors in Domestic Animal Reproduction: A Clinical Issue?

Magnusson

Persson

2015

Reprod Domestic Animals

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Contents The objective of this review was to discuss whether endocrine disruption is a clinical concern in domestic animal reproduction. To that end, we firstly summarize the phenomenon of endocrine disruption, giving examples of the agents of concern and their effects on the mammalian reproductive system. Then there is a brief overview of the literature on endocrine disruptors and domestic animal reproduction. Finally, the clinical implications of endocrine disruptors on the reproductive system of farm animals as well as in dogs and cats are discussed. It is concluded that the evidence for clinical cases of endocrine disruption by chemical pollutants is weak, whereas for phytooestrogens, it is well established. However, there is concern that particular dogs and cats may be exposed to man-made endocrine disruptors.

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“…The lowest observable adverse effect level (LOAEL) of dietary exposure of mink to a coplanar PCB126 contaminated fish diet on reproduction, kit survivability and growth was 2.4 μg PCB 126/kg feed (Beckett 2008). Levels of total PCBs in whole carp Cyprinus carpio collected at three sites downstream of the two GE facilities was 36 μg PCBs/g wet wt (Bursian et al 2013b). Thus, it might be expected that mink from the Hudson River corridor would bioaccumulate high levels of PCBs, be sensitive to PCBs-induced toxicities, and that reproductive effects might be felt at the population level.…”

Section: Introductionmentioning

confidence: 99%

“…Similarly, those fed a diet supplemented with PCB-contaminated carp (1.1 mg total PCBs/kg feed) from the Saginaw River, Michigan, experienced maxillary and mandibular squamous epithelial proliferation, a condition that could lead to tooth loss and reduced survival in the wild (Bursian et al 2006b). Furthermore, ranched mink fed diets containing 2.5 to 20% of Hudson River-collected fish suffered a significant increase in stillborn kits at the two highest doses, significantly decreased survivorship by 31 weeks of age at two lower doses, and jaw lesions at the lowest dose of PCBs used (Bursian et al 2013ab). …”

Section: Introductionmentioning

confidence: 99%

Genetic variation and population structure of American mink Neovison vison from PCB-contaminated and non-contaminated locales in eastern North America

et al. 2015

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American mink Neovison vison may be particularly vulnerable to toxicities of persistent contaminants such as PCBs because of their aquatic-based diet, position near the top of the food web, and small deme sizes. Furthermore, ranched mink are sensitive to reproductive toxicities of fish diets from PCB-polluted sites. The upper Hudson River is highly contaminated with PCBs and previous studies have shown elevated hepatic burdens of total and coplanar PCBs in mink collected near the river compared with those from more distant locales in New York and elsewhere. We hypothesized that bioaccumulation of PCBs in Hudson River mink has reduced their levels of genetic diversity or altered their genetic population structure. To address this, we conducted microsatellite DNA analysis on collections made in proximity to and from more distant locales in the Hudson River watershed, elsewhere in New York State, and at other sites in eastern North America including New Brunswick, four locales in Ontario, multiple drainages in Maine, and two ecoregions in Rhode Island. We did not find reduced genetic diversity at the individual or population levels in mink collected near (< 6 km) to PCB hotspots in the Hudson River nor evidence of altered population structure. Consistent with their distribution in small localized and isolated demes, we did find significant genetic population structure among many mink collections in New York State and elsewhere. Depending on the analytical approach used, genetically distinct populations numbered between 16 when using STRUCTURE to 19-20 when using Exact G tests, FST, or AMOVA analyses. Genetically distinct population units were found among major ecoregions and minor ecoregions in New York State, among different hydrologic subunits within the Hudson River watershed, among spatially separate locales in Ontario, and among most watersheds in Maine. However, despite this localization and potential heightened impact of stressors, genetic diversity and genetic population structure in mink does not seem to be affected by their bioaccumulation of high levels of PCBs of Hudson River origin.

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Dietary exposure of mink (Mustela vison) to fish from the upper Hudson River, New York, USA: Effects on reproduction and offspring growth and mortality

Cited by 24 publications

References 28 publications

Using energy budgets to combine ecology and toxicology in a mammalian sentinel species

Using energy budgets to combine ecology and toxicology in a mammalian sentinel species

Endocrine Disruptors in Domestic Animal Reproduction: A Clinical Issue?

Genetic variation and population structure of American mink Neovison vison from PCB-contaminated and non-contaminated locales in eastern North America

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