Dietary effect of pomegranate seed oil on immune function and lipid metabolism in mice

Yamasaki, Masao; Kitagawa, Takae; Koyanagi, Nami; Chujo, Hitomi; Maeda, Hidenori; Kohno-Murase, Junko; Imamura, Jun; Tachibana, Hirofumi; Yamada, Koji

doi:10.1016/j.nut.2005.03.009

Cited by 134 publications

(117 citation statements)

References 25 publications

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“…It was found that 4 w treatment with PSO diminished cholesterol, high-density lipoprotein (HDL)-cholesterol ratio and triglyceride concentration compared to the placebo group in a placebo-controlled, double-blind, clinical trial. They also showed no beneficial correlation between PSO consumption and insulin profiles [44] . Moreover, PSO was demonstrated to have an antioxidant activity and useful effects on lipid profile of dyslipidemic patients [25,45] .…”

Section: Pa and Diabetes Mellitusmentioning

confidence: 91%

“…Finally, this study demonstrated that PSO ameliorated insulin secretion without altering fasting glucose levels [40] . However, Yamasaki et al demonstrated that administration of PSO (0.1 and 1.0% as PA) did not show significant effects on the epididymal and perirenal adipose tissue weight in male mice [44] . It was found that 4 w treatment with PSO diminished cholesterol, high-density lipoprotein (HDL)-cholesterol ratio and triglyceride concentration compared to the placebo group in a placebo-controlled, double-blind, clinical trial.…”

Section: Pa and Diabetes Mellitusmentioning

confidence: 98%

“…They also demonstrated that PA diminished hepatic triglyceride concentration and fatty tissue weights in mice, which may be partially related to an increase of fatty acid â-oxidation activity [42] . But some reported data on the effect of PSO on lipid metabolism and concentration have been controversial [43,44] . Contrary to what has been documented above, Nekooeian et al found that PSO did not decrease blood glucose but enhanced insulin levels and this effect occurred despite any change in blood glucose levels.…”

Section: Pa and Diabetes Mellitusmentioning

confidence: 99%

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Hatice Asli Bedel, Nur Tukel Turgut, Aysegul Ugur Kurtoglu, Coskun Usta

Bedel¹,

Turgut²,

Kurtoğlu³

et al. 2017

pharmaceutical-sciences

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Bedel, et al.: Pharmacology of Punicic AcidPlant extracts and nutraceuticals are the most ancient and widespread form of medication employed by the general population. The pomegranate is a prehistoric, mystical and a highly differentiated fruit. Moreover, pomegranate is found in some medicinal systems as a cure for a variety of illnesses. Pomegranate has been used for a long time for nutraceutical purposes. Current research indicates that the most medicinally useful pomegranate components include ellagitannins, anthocyanins, anthocyanidins, flavonoids, estrogenic flavonols and flavones. Also pomegranate seed oil contains 64-83% punicic acid. Therefore, this review focussed on the effects of punicic acid, particularly those that have been reported such as the anticarcinogenic, antioxidant, antiinflammatory and antidiabetic effects. As nutraceuticals appear to play a major role in the prophylaxis of various diseases, punicic acid could be an important and phytoconstituent among these agents. Nutraceuticals are generally regarded as safe to use with lower incidence of side effects. In spite of all these reports it is obvious that there is a clear need for more clinical studies.

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Section: Pa and Diabetes Mellitusmentioning

confidence: 91%

Section: Pa and Diabetes Mellitusmentioning

confidence: 98%

Section: Pa and Diabetes Mellitusmentioning

confidence: 99%

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Hatice Asli Bedel, Nur Tukel Turgut, Aysegul Ugur Kurtoglu, Coskun Usta

Bedel¹,

Turgut²,

Kurtoğlu³

et al. 2017

pharmaceutical-sciences

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“…An earlier study by Ike et al (9) showed that α-eleostearic acid (9Z, 11E, 13E-CLNA isomer) isolated from bitter gourd could induce interferon-γ production in mice treated with heat-inactivated Propionibacterium acnes, suggesting that T helper 1 (Th1) cellular immunity can be activated by α-eleostearic acid, which is responsible for the defense against intracellular parasitic infection. By contrast, Yamasaki et al (10) reported that consumption of pomegranate seed oil that is rich in punicic acid (9Z, 11E, 13Z-CLNA isomer) could ameliorate the function of B cells, which have a key role in the humoral immune response. These studies started to explain the immunostimulatory activities of CLNAs, however, the anti-allergic activity of CLNAs and their modulatory effects on mast cells have not yet been investigated.…”

Section: Introductionmentioning

confidence: 93%

Anti-allergic effect of the naturally-occurring conjugated linolenic acid isomer, jacaric acid, on the activated human mast cell line-1

Liu¹,

Leung²

2015

Biomedical Reports

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Abstract. The present study aimed to investigate the immunomodulatory effect of jacaric acid, a naturally-occurring conjugated linolenic acid isomer that can be found in jacaranda seed oil, on the activated human mast cell line-1 (HMC-1). Our previous studies have demonstrated that jacaric acid only exerted minimal, if any, cytotoxicity on normal murine cells. In the present study, jacaric acid at concentrations ≤100 µM did not exhibit direct cytotoxicity on human peripheral blood mononuclear cells after 72 h of incubation, as determined by the MTT reduction assay. By contrast, jacaric acid could alleviate the calcium ionophore A23187 and phorbol 12-myristate 13-acetate-triggered allergic response in the HMC-1 cells at concentrations that were non-cytotoxic to the HMC-1 cells. Following pre-treatment with jacaric acid, the secretion of two inflammatory mediators, β-N-acetylglucosaminidase and tryptase, as well as the T helper 2 cytokines [interleukin (IL)-4 and IL-13] was significantly reduced in HMC-1 cells. The alleviation of allergic response was accompanied by downregulation of the matrix metalloproteinase-2 and -9 proteins and upregulation of the tissue inhibitor of metalloproteinase-1 protein. Collectively, the results indicated that the naturally-occurring jacaric acid exhibits a suppressive effect on the allergic response in activated human mast cells in vitro, and this could not be attributed to the direct cytotoxicity of jacaric acid on the treated cells.

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“…It has been shown that pomegranate seed oil (PSO) has wide range of beneficial biological attributes such as immunomodulatory and anti-inflammatory, anti-cancerous, and antioxidant properties (Kim et al, 2002;Kohno et al, 2004;Lansky & Newman, 2007;Singh, Chidambara Murthy, & Jayaprakasha, 2002;Yamasaki et al, 2006). Furthermore, considering oxidative modification hypothesis and role of Ox-LDL in atherosclerosis (Pirillo, Norata, & Catapano, 2013), many studies have been conducted on using various pomegranate-derived products as natural antioxidants to improve oxidative stress and decrease atherosclerosis risk factors.…”

Section: Introductionmentioning

confidence: 99%

Effects of pomegranate seed oil and fermented juice polyphenols fraction in different solvents on copper-induced LDL oxidation

Faisi

Fattahi

Raffel

et al. 2018

CyTA - Journal of Food

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Effects of pomegranate seed oils extracted with supercritical fluid or cold press methods (SFE-PSO and CP-PSO), unsaponifiable (N), and fermented juice polyphenols (W) fractions of pomegranate as well as olive oil and alpha-tocopherol, as pure or in different solvents were evaluated on preventing copper-induced LDL oxidation. The results showed addition of pure SFE-PSO, CP-PSO, N fractions, and olive oil had no significant effect on LDL oxidation. Also using various solvents did not help in the term of extending the oxidation lag phase. However, adding 0.5, 1, 1.5, and 3 µL of the W solution in EtOH could delay the lag phase 103.5, 145.9, 200, and 199.1 min, respectively. There was no synergistic effect between W and N on inhibiting the oxidation. It can be concluded that polyphenolic fraction of pomegranate juice can act as antiatherogenic supplementation and natural preservative for meat and fatty foods through direct inhibition of LDL oxidation.Efectos del aceite de semilla de granada y la fracción polifenólica de jugo fermentado, mezclados con distintos solventes, en la oxidación de LDL inducida por cobre RESUMEN A efectos de prevenir la oxidación de LDL inducida por cobre, el presente estudio se propuso evaluar los efectos que los aceites de semilla de granada extraídos con fluido supercrítico o métodos de presión en frío (SFE-PSO y CP-PSO), y las fracciones polifenólicas de jugo de granada fermentado e insaponificable (N), así como el aceite de oliva y el alfa-tocoferol, tienen en estado puro o en distintos solventes. Los resultados mostraron que la adición de fracciones SFE-PSO, CP-PSO, N puras y aceite de oliva no produjo ningún efecto significativo en la oxidación de LDL. Por otra parte, el uso de varios solventes no contribuyó a extender la fase de latencia de la oxidación. Sin embargo, al agregar 0.5, 1, 1.5 y 3 µl de la solución W en EtOH se pudo retrasar la fase de latencia 103.5, 145.9, 200 y 199.1 minutos, respectivamente. No se produjo ningún efecto sinérgico entre W y N en la inhibición de oxidación. Por lo tanto, se concluye que la fracción polifenólica del jugo de granada puede actuar como suplemento antiaterogénico y conservador natural de carnes y alimentos grasos mediante la inhibición directa de la oxidación de LDL. ARTICLE HISTORY

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Dietary effect of pomegranate seed oil on immune function and lipid metabolism in mice

Cited by 134 publications

References 25 publications

Hatice Asli Bedel, Nur Tukel Turgut, Aysegul Ugur Kurtoglu, Coskun Usta

Hatice Asli Bedel, Nur Tukel Turgut, Aysegul Ugur Kurtoglu, Coskun Usta

Anti-allergic effect of the naturally-occurring conjugated linolenic acid isomer, jacaric acid, on the activated human mast cell line-1

Effects of pomegranate seed oil and fermented juice polyphenols fraction in different solvents on copper-induced LDL oxidation

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