Dietary effect of Ganoderma lucidum mushroom on blood pressure and lipid levels in spontaneously hypertensive rats(SHR).

Kabir, Yearul; Kimura, Shuichi; Tamura, Tsutomu

doi:10.3177/jnsv.34.433

Cited by 107 publications

(47 citation statements)

References 10 publications

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“…On the other hand, different studies reported the relationship between low plasma cholesterol levels and mushrooms consumption [67][68][69][70]. In animal experiments, Kabir et al [71] investigated the dietary effect of G. lucidum on blood pressure and their results showed a significant reduction of the plasma cholesterol level in animals fed with G. lucidum, and these observations have been reported previously. Although these results are suggesting that an adequate dietary supplementation might prevent from blood pressure increase and reduce plasma and liver cholesterol levels, the mechanism of this action is still unclear and has to be understood.…”

Section: Mechanisms Of Action Of G Lucidum Polysaccharides and Terpensupporting

confidence: 48%

Ganoderma lucidum Polysaccharides and Terpenoids: Profile and Health Benefits

Benkeblia¹

2016

J Food Nutri Diete

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Recent studies have shown that mushrooms are recognized as a promising source of functional and nutraceutical compounds. The species Ganoderma lucidum (also called Reishi or Lingzhi) is a mushroom used in medicine because Chinese attributes to this fungus better health and longevity. Among the numerous bioactive compounds identified in G. lucidum are polysaccharides mostly β-glucans, heteropolysaccharides or glycoproteins, terpenoids mostly ganoderic acids and derivatives, as well as many other bioactive proteinases that contribute to health and diseases prevention. The aim of this review is to report on the profile of the most bioactive compounds, particularly polysaccharides and terpenoids of G. lucidum.

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Section: Mechanisms Of Action Of G Lucidum Polysaccharides and Terpensupporting

confidence: 48%

Ganoderma lucidum Polysaccharides and Terpenoids: Profile and Health Benefits

Benkeblia¹

2016

J Food Nutri Diete

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“…has recommended mushroom foods to solve the problem of malnutrition (Sohi, 1988). Mannentake (Ganoderma lucidum) are known to lower blood pressure and serum cholesterol concentration of hypertensive rats (Kabir et al, 1988). Lentinus tigrinus and G. lucidium are proved anticholesterolmic (Ren et al, 1989).…”

Section: Medicinal Importancementioning

confidence: 99%

Nutritional and medicinal importance of mushrooms

Wani¹,

Bodha²,

Wani³

2010

J. Med. Plants Res.

232

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Mushrooms had long been used for medicinal and food purposes since decades. It is now increasingly recognized that correct diet, controls and modulates many functions of human body and consequently participates in the maintenance of state of good health, necessary to reduce the risk of many diseases. Modern pharmacological research confirms large parts of traditional knowledge regarding the medicinal effects of mushrooms due to their antifungal, antibacterial, antioxidant and antiviral properties, besides being used as functional foods. This paper sums up diverse beneficial health effects of mushrooms to humans, in the form of proteins, carbohydrates, fats, vitamins, minerals, food and drugs, and medicines.

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“…These substances are known to have many biological activities, including anti-tumor (2), immunomodulatory (3), anti-viral (4), anti-hepatitis (5), antioxidant (6), antihypertensive (7,8) and anti-diabetic activities (9). It has been reported that Ganoderma lucidum extracts can inhibit tumor formation and the proliferation of breast and prostate cancer, hepatoma, melanoma lymphoma and myeloid leukemia cell lines (10-12).…”

Section: Introductionmentioning

confidence: 99%

“…It has also become a popular dietary supplement in Western countries. Ganoderma lucidum contains many different bioactive compounds, which mainly include triterpenoids, polysaccharides, nucleotides, sterols, steroids, fatty acids, proteins/peptides and trace elements (1).These substances are known to have many biological activities, including anti-tumor (2), immunomodulatory (3), anti-viral (4), anti-hepatitis (5), antioxidant (6), antihypertensive (7,8) and anti-diabetic activities (9). It has been reported that Ganoderma lucidum extracts can inhibit tumor formation and the proliferation of breast and prostate cancer, hepatoma, melanoma lymphoma and myeloid leukemia cell lines (10-12).…”

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confidence: 99%

Ganoderma lucidum exerts anti-tumor effects on ovarian cancer cells and enhances their sensitivity to cisplatin

Zhao

Ye²,

Fu³

et al. 2011

Int J Oncol

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Abstract. Ganoderma lucidum is a herbal mushroom known to have many health benefits, including the inhibition of tumor cell growth. However, the effect of Ganoderma lucidum on epithelial ovarian cancer (EOC), the most fatal gynecological malignancy, has not yet been reported. In this study, we determined whether Ganoderma lucidum regulates EOC cell activity. Using several cell lines derived from EOC, we found that Ganoderma lucidum strongly decreased cell numbers in a dose-dependent manner. Ganoderma lucidum also inhibited colony formation, cell migration and spheroid formation. In particular, Ganoderma lucidum was effective in inhibiting cell growth in both chemosensitive and chemoresistant cells and the treatment with Ganoderma lucidum significantly enhanced the effect of cisplatin on EOC cells. Furthermore, Ganoderma lucidum induced cell cycle arrest at the G2/M phase and also induced apoptosis by activating caspase 3. Finally, Ganoderma lucidum increased p53 but inhibited Akt expression. Taken together, these findings suggest that Ganoderma lucidum exerts multiple anti-tumor effects on ovarian cancer cells and can enhance the sensitivity of EOC cells to cisplatin. IntroductionGanoderma lucidum is a herbal mushroom that has been widely used in preventive medicines in China and other Asian countries for over 2,000 years. It has also become a popular dietary supplement in Western countries. Ganoderma lucidum contains many different bioactive compounds, which mainly include triterpenoids, polysaccharides, nucleotides, sterols, steroids, fatty acids, proteins/peptides and trace elements (1).These substances are known to have many biological activities, including anti-tumor (2), immunomodulatory (3), anti-viral (4), anti-hepatitis (5), antioxidant (6), antihypertensive (7,8) and anti-diabetic activities (9). It has been reported that Ganoderma lucidum extracts can inhibit tumor formation and the proliferation of breast and prostate cancer, hepatoma, melanoma lymphoma and myeloid leukemia cell lines (10-12). Thus, Ganoderma lucidum could be used as a potential therapeutic agent in the form of a dietary supplement for cancer patients.Epithelial ovarian cancer (EOC) is the most common form of ovarian cancer and the leading cause of death from gynecological disorders (13). The high mortality rate of EOC is mainly due to the late diagnosis and the lack of effective treatments for the late stages of the disease (14). The most effective treatment for EOC is surgery plus platinum-based chemotherapy, with drugs such as cisplatin. However, the majority of patients ultimately experience chemoresistance and recurrence of their disease (15). Considering the high mortality rate of ovarian cancer due to the absence of effective treatment in advanced stages or during relapse, new therapeutic strategies are urgently required.In this study, we examined the effects of Ganoderma lucidum on cell proliferation and migration in several ovarian cancer cell lines. Our results show that Ganoderma lucidum inhibits cell growth, migration and...

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Dietary effect of Ganoderma lucidum mushroom on blood pressure and lipid levels in spontaneously hypertensive rats(SHR).

Cited by 107 publications

References 10 publications

Ganoderma lucidum Polysaccharides and Terpenoids: Profile and Health Benefits

Ganoderma lucidum Polysaccharides and Terpenoids: Profile and Health Benefits

Nutritional and medicinal importance of mushrooms

Ganoderma lucidum exerts anti-tumor effects on ovarian cancer cells and enhances their sensitivity to cisplatin

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