Dietary Curcumin Intervention Targets Mouse White Adipose Tissue Inflammation and Brown Adipose Tissue UCP1 Expression

Song, Zhuolun; Revelo, Xavier S.; Shao, Weijuan; Tian, Lili; Zeng, Kejing; Lei, Helena; Sun, Hong; Woo, Minna; Winer, Daniel A.; Jin, Tianru

doi:10.1002/oby.22110

Cited by 72 publications

(48 citation statements)

References 45 publications

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“…Primary adipocytes treated with curcumin have increased UCP1, PPARα and PGC-1α mRNA levels. Curcumin treatment increased UCP1, PPARα, PPARγ and PGC-1α mRNA levels in mBACs (Table 1) [69].…”

Section: Effects Of Curcumin: In Vitro Adipocyte Studiesmentioning

confidence: 99%

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Antidiabetic Properties of Curcumin I: Evidence from In Vitro Studies

2020

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Type 2 diabetes mellitus (T2DM) is a growing metabolic disease characterized by insulin resistance and hyperglycemia. Current preventative and treatment strategies for T2DM and insulin resistance lack in efficacy resulting in the need for new approaches to prevent and manage/treat the disease better. In recent years, epidemiological studies have suggested that diets rich in fruits and vegetables have beneficial health effects including protection against insulin resistance and T2DM. Curcumin, a polyphenol found in turmeric, and curcuminoids have been reported to have antioxidant, anti-inflammatory, hepatoprotective, nephroprotective, neuroprotective, immunomodulatory and antidiabetic properties. The current review (I of II) summarizes the existing in vitro studies examining the antidiabetic effects of curcumin, while a second (II of II) review summarizes evidence from existing in vivo animal studies and clinical trials focusing on curcumin’s antidiabetic properties.

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Section: Effects Of Curcumin: In Vitro Adipocyte Studiesmentioning

confidence: 99%

“…Treatment of primary adipocytes and mouse brown adipocyte cells (mBACs) with curcumin (2 µM) for 10 h resulted in improved thermogenesis [69]. Primary adipocytes treated with curcumin have increased UCP1, PPARα and PGC-1α mRNA levels.…”

Section: Effects Of Curcumin: In Vitro Adipocyte Studiesmentioning

confidence: 99%

Antidiabetic Properties of Curcumin I: Evidence from In Vitro Studies

2020

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“…Specifically, Curcumin intervention was found to reduce mouse WAT inflammation and increase BAT UCP1 expression via PPAR-dependent and -independent mechanisms. It reduces macrophage infiltration and proinflammation cytokine expression in both macrophages and adipocytes along with increased energy expenditure and body temperature in response to cold (209).…”

Section: Anti-inflammatory Pathways and Bat Functionmentioning

confidence: 99%

“…Importantly, ω3-FAs (n-3 polyunsaturated fatty acids (n-3PUFAs) have anti-inflammatory effects and may significantly impact chronic inflammatory diseases including obesity related disorders (210). An ω3enriched diet, in non-obesogenic non-inflammatory conditions, leads to synthesis of oxylipins which have an anti-inflammatory response in both WAT and BAT with a macrophage modulation effect, but with no influence on inflammatory cytokine secretion (209). FFAs are active stimulators for members of the rhodopsinlike family of G protein-coupled receptors (GPCRs) including GPR40, GPR41, GPR43, GPR84, and GPR120 (211,212).…”

Section: Anti-inflammatory Pathways and Bat Functionmentioning

confidence: 99%

Inflammatory Signaling and Brown Fat Activity

Omran

Christian

2020

Front. Endocrinol.

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Obesity is characterized by a state of chronic inflammation in adipose tissue mediated by the secretion of a range of inflammatory cytokines. In comparison to WAT, relatively little is known about the inflammatory status of brown adipose tissue (BAT) in physiology and pathophysiology. Because BAT and brown/beige adipocytes are specialized in energy expenditure they have protective roles against obesity and associated metabolic diseases. BAT appears to be is less susceptible to developing inflammation than WAT. However, there is increasing evidence that inflammation directly alters the thermogenic activity of brown fat by impairing its capacity for energy expenditure and glucose uptake. The inflammatory microenvironment can be affected by cytokines secreted by immune cells as well as by the brown adipocytes themselves. Therefore, pro-inflammatory signals represent an important component of the thermogenic potential of brown and beige adipocytes and may contribute their dysfunction in obesity.

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“…Recently, Wang et al showed that a dietary CUR supplement improved insulin sensitivity and decreased body fat in mice with high-fat diet (HFD)-induced obesity [19] and obese/diabetic mice [20]. A dietary CUR supplement has been shown to relieve low-grade chronic WAT in ammation and upregulate BAT UCP1 expression in HFD mice [21]. In addition, CUR has been reported to be an anti-adipocyte dietary bioactive component largely involved in modulating the early stage of adipocyte differentiation [22].…”

Section: Introductionmentioning

confidence: 99%

Dietary Curcumin Supplement Promotes Browning and Energy Expenditure in Postnatal Overfed Rats

Zhu

Yan

et al. 2020

Preprint

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Background: Early postnatal overfeeding could result in metabolic imprinting that decreases energy expenditure and induces white adipose tissue (WAT) gain throughout life. The aim of this study is to investigate the effect of curcumin (CUR) on thermogenesis and WAT browning in postnatal overfed rats.Methods and results: Litter sizes were adjusted to three (small litters, SL) or ten (normal litters, NL) to mimic early postnatal overfeeding or normal feeding from postnatal day 3. After weaning, the SL rats were fed with a standard diet (SL) or a diet supplemented with 1% (SL1%CUR) or 2% (SL2%CUR) CUR for ten weeks. At postnatal 13 weeks, SL rats with 1% or 2% CUR supplement had lower body weight and less WAT gain, had increased lean mass ratio, and their glucose tolerance and blood lipid levels had recovered to normal when compared to SL rats that did not receive the supplement. Moreover, increased respiratory exchange ratio (RER) and heat production were consistent with the expression of uncoupling protein 1 (UCP1) and other browning-related genes in the subcutaneous adipose tissue (SAT) of the SL2% CUR rats but not of the SL1% CUR rats. In addition, 2% CUR dietary supplement enhanced the serum norepinephrine (NE) levels in SL rats, which was accompanied by upregulated mRNA levels of β3-adrenergic receptor (β3-AR) in SAT.Conclusion: Dietary CUR supplement attenuates body weight gain and metabolic disorders of SL rats. The beneficial effects were probably induced by promoting browning of SAT and energy expenditure, and it was more effective in SL with 2% CUR supplement.

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Dietary Curcumin Intervention Targets Mouse White Adipose Tissue Inflammation and Brown Adipose Tissue UCP1 Expression

Abstract: Curcumin intervention targets both WAT inflammation and BAT UCP1 expression. These observations advanced our knowledge on the metabolic beneficial effects of the curry compound curcumin, bringing us a novel perspective on dietary polyphenol research.

Cited by 72 publications

References 45 publications

Antidiabetic Properties of Curcumin I: Evidence from In Vitro Studies

Antidiabetic Properties of Curcumin I: Evidence from In Vitro Studies

Inflammatory Signaling and Brown Fat Activity

Dietary Curcumin Supplement Promotes Browning and Energy Expenditure in Postnatal Overfed Rats

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