Dietary consumption and serum pattern of bioactive fatty acids in NAFLD patients

López-Bautista, Fabiola; Barbero-Becerra, Varenka J.; Rios, Marı́a Yolanda; Ramírez-Cisneros, M. Ángeles; Sánchez-Pérez, Cristell A.; Ramos-Ostos, Martha Helena; Uribe, Misael; Chávez-Tapia, Norberto C.; Juárez-Hernández, Eva

doi:10.1016/j.aohep.2020.06.008

Cited by 7 publications

(9 citation statements)

References 39 publications

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“…In particular, n-3 polyunsaturated FAs (PUFAs), eicosapentaenoic acid (EPA, 20:5 n-3), and docosahexaenoic acid (DHA, 22:6 n-3) can increase fat oxidation and reduce endogenous lipid production at the gene level [13,14]. However, patients with NAFLD, especially obese ones, mostly have an impaired n-3 PUFA status and a high n-6/n-3 ratio that can be improved by a proper diet [15,16]. Furthermore, pooled estimates of case-control studies have shown that blood and/or liver DHA contents are lower in NAFLD patients [17].…”

Section: Introductionmentioning

confidence: 99%

Calorie-Restricted Mediterranean and Low-Fat Diets Affect Fatty Acid Status in Individuals with Nonalcoholic Fatty Liver Disease

et al. 2020

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Lifestyle modifications are the main support of nonalcoholic fatty liver disease (NAFLD) therapy. Weight loss is one of the primary goals in NAFLD, but the effects of different calorie-restricted diets remain unclear. Thus, we evaluated the effects of two calorie-restricted diets—the Mediterranean diet (Med diet) and low-fat diet—on liver status, cardiometabolic markers, and fatty acid profiles in patients with NAFLD. Twenty-four overweight/moderately obese men were randomly assigned to consume one of these diets. Lipid levels, glucose, insulin, liver enzymes, steatosis, and fatty acid profiles of serum and erythrocytes phospholipids were assessed. After 3 months, all participants had a significant weight loss (>9%), with improvements in waist circumference, body fat %, index of visceral adiposity (VAI), lipid accumulation product, fatty liver (FLI), and hepatic steatosis (HSI) index (p < 0.001). Both diets significantly lowered triglycerides, total and LDL-cholesterol, liver enzymes, fasting glucose, insulin, and HOMA-IR index. Fatty acid profiles were enhanced after both diets, with a significantly decreased n-6/n-3 ratio. Participants on the Med diet had higher levels of HDL-cholesterol and monounsaturated and n-3 docosahexaenoic acids in serum phospholipids and lower levels of saturated fatty acids, triglycerides, TG/HDL ratio, and FLI when compared to participants on the low-fat diet. Our results indicate that dietary patterns and calorie restriction represent central therapeutic issues in the improvement of obesity-related cardiometabolic alterations that are involved in the mechanism of hepatic steatosis. The Med diet may contribute to disease treatment even more than the low-fat diet since it leads to decreased saturated and increased monounsaturated and n-3 polyunsaturated fatty acid status and improved FLI in NAFLD patients.

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Section: Introductionmentioning

confidence: 99%

Calorie-Restricted Mediterranean and Low-Fat Diets Affect Fatty Acid Status in Individuals with Nonalcoholic Fatty Liver Disease

et al. 2020

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“…36 Regarding sugar consumption in NAFLD, patients have been found to consume higher amounts of glucose and fructose compared to non-NAFLD individuals. 34 Total fructose consumption was higher in NAFLD patients compared with healthy control individuals. 36,37 Increased fructose consumption has been associated with decreased hepatic insulin sensitivity and with low high-density lipoprotein (HDL) cholesterol, increased caloric intake, hyperuricemia, increased hepatic inflammation and hepatocyte ballooning, and increased fibrosis severity in NAFLD/NASH patients.…”

Section: Genetic Hormonal Environmental Dietary Factors and Human Naf...mentioning

confidence: 91%

“…35 More specifically, in patients with severe NAFLD higher consumption of stearic (a saturated bioactive) and palmitoleic (a monounsaturated bioactive) fatty acids was observed, while only palmitoleic was found significantly higher consumed by patients with moderate and severe NAFLD compared to those with non-NAFLD or mild-NAFLD. 34 Furthermore, a weak but significantly positive correlation between consumption of palmitic, stearic, palmitoleic, oleic (monounsaturated bioactive), and linoleic (polyunsaturated) fatty acids and liver stiffness was observed in severe NAFLD patients. However, it should be noted that the serum percentage of bioactive fatty acids was not correlated to their dietary consumption and did not differ between NAFLD and non-NAFLD patients.…”

Section: Genetic Hormonal Environmental Dietary Factors and Human Naf...mentioning

confidence: 97%

“…23 Dietary consumption of bioactive fatty acids has been related to an increased or decreased risk of developing NAFLD, and appears to be different according to its severity. 34 NAFLD patients have been found to consume more saturated (palmitic and stearic) and polyunsaturated (linoleic, linolenic, and arachidonic) fatty acids than healthy control subjects, while saturated fatty acid intake was positively associated with hepatic fat fraction and intrahepatic lipid. 35 More specifically, in patients with severe NAFLD higher consumption of stearic (a saturated bioactive) and palmitoleic (a monounsaturated bioactive) fatty acids was observed, while only palmitoleic was found significantly higher consumed by patients with moderate and severe NAFLD compared to those with non-NAFLD or mild-NAFLD.…”

Section: Genetic Hormonal Environmental Dietary Factors and Human Naf...mentioning

confidence: 98%

“…However, it should be noted that the serum percentage of bioactive fatty acids was not correlated to their dietary consumption and did not differ between NAFLD and non-NAFLD patients. 34 Sugar consumption has increased over the last years globally and while glucose acts as an important energy source for the entire body, fructose metabolism takes place mainly in the liver and has thus been suspected to contribute to the increasing NAFLD incidence. 36 Regarding sugar consumption in NAFLD, patients have been found to consume higher amounts of glucose and fructose compared to non-NAFLD individuals.…”

Section: Genetic Hormonal Environmental Dietary Factors and Human Naf...mentioning

confidence: 99%

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Endoplasmic reticulum stress in nonalcoholic (metabolic associated) fatty liver disease (NAFLD/MAFLD)

Flessa

Kyrou

Nasiri-Ansari

et al. 2022

J of Cellular Biochemistry

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Nonalcoholic fatty liver disease (NAFLD) is characterized by hepatic fat accumulation in the absence of excessive alcohol consumption and is strongly associated with obesity, type 2 diabetes (T2DM) and other metabolic syndrome features. NAFLD is becoming increasingly prevalent and currently constitutes the leading cause of hepatocellular carcinoma (HCC). Recently, the term metabolic (dysfunction) associated fatty liver disease (MAFLD) has been proposed reflecting more accurately the underlying pathogenesis and the cardiometabolic disorders associated to NAFLD/MAFLD. Given the vital metabolic functions of the liver to maintain the body homeostasis, an extended endoplasmic reticulum (ER) network is mandatory in hepatocytes to retain its capacity to adapt to the multiple extracellular and intracellular signals mediating metabolic changes. Dysfunction of hepatocyte ER homeostasis and disturbance of its interaction with mitochondria have been recognized to be involved in the NAFLD pathophysiology. Apart from hepatocytes, hepatic stellate cells, and Kupffer cells have been shown to play an important role in the occurrence of NAFLD and progression to nonalcoholic steatohepatitis (NASH) with possibly different roles in the different stages of the NAFLD spectrum. Furthermore, excess lipid accumulation in the liver causes lipotoxicity which interacts with ER stress and culminates in inflammation and hepatocellular damage, mechanisms crucially implicated in NASH pathogenesis. Finally, the circadian clock machinery regulates ER stress‐related pathways and vice versa, thus controlling the homeostasis of the liver metabolism and being implicated in the NAFLD progression. This review presents a comprehensive overview of the current knowledge supporting the impact of ER stress signaling on NAFLD, whilst summarizing potential therapeutic interventions targeting this process.

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G protein-coupled receptors: Key molecules in metabolic associated fatty liver disease development

et al. 2021

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Dietary consumption and serum pattern of bioactive fatty acids in NAFLD patients

Cited by 7 publications

References 39 publications

Calorie-Restricted Mediterranean and Low-Fat Diets Affect Fatty Acid Status in Individuals with Nonalcoholic Fatty Liver Disease

Calorie-Restricted Mediterranean and Low-Fat Diets Affect Fatty Acid Status in Individuals with Nonalcoholic Fatty Liver Disease

Endoplasmic reticulum stress in nonalcoholic (metabolic associated) fatty liver disease (NAFLD/MAFLD)

G protein-coupled receptors: Key molecules in metabolic associated fatty liver disease development

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