Dietary constituents and rifampicin absorption

Purohit, Shobha; Sarkar, S.K.; Gupta, Mansi; Jain, Dilip; Gupta, Puneet; Mehta, Y.

doi:10.1016/0041-3879(87)90034-1

Cited by 9 publications

(4 citation statements)

References 2 publications

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“…The only medicine that patients are advised to take without food is rifampicin, because absorption of the drug is reduced when it is taken with fat. However, absorption of rifampicin is apparently unaffected by consumption of protein and carbohydrates, and therefore it could be consumed with a non-fat-containing porridge or with tea or coffee and toast with jam [122,123].…”

Section: Impact Of Nutritional Status and Food Intake On Tuberculosismentioning

confidence: 99%

Addressing Tuberculosis in the Context of Malnutrition and HIV Coinfection

2010

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Section: Impact Of Nutritional Status and Food Intake On Tuberculosismentioning

confidence: 99%

Addressing Tuberculosis in the Context of Malnutrition and HIV Coinfection

2010

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“…In literature, so far, there are only a few reports available for simultaneous FNAC and culture used for the diagnosis of tuberculosis. Purohit, et al have used Mantoux test, skiagram chest, histopathology and culture of mycobacteria as diagnostic parameters [10].…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Fine Needle Aspiration Cytology, Ziehl-Neelsen (Z-N) Stain and Culture (Bactec) in Diagnosis of Tuberculosis Lymphadenitis

HM¹,

UR²,

HP³

et al. 2012

Int J of Micr Res

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Background-Tuberculous Lymphadenitis is the commonest form of extra pulmonary tuberculosis and tissue diagnosis is the main stay in the diagnosis of extra-pulmonary tuberculosis. This study was conducted to compare cytology, ZN staining and culture findings of clinically suspected tuberculous lymphadenitis cases.Methods-In the Present Study, clinically suspected cases of lymphadenopathy were undergone fine needle aspiration. The aspirates were examined cytologically followed by ZN staining and BACTEC culture.Results-The cytology suggestive of tuberculous lymphadenitis was found in 46 (76.6%) cases out of total 61 cases. Ziehl Neelsen stain demonstrated positive for acid fast bacilli (AFB) in 14 (22.9%) cases and mycobacteria isolated from BACTEC in36 (59%) cases. Out of 61 cases 15(24.5%) cases showed pus formation and in cytological examination 13 of those cases reported as tuberculous lymphadenitis. Aspiration mixed with blood demonstrated AFB positive in 2 (5.88%) and mycobacteria were isolated in 16 (48.48%) cases and cytology suggest tuberculous lymphadenitis in 21 (63.63%) cases. Seven out of Nine cases of necrosis with or without neutrophils show presence of AFB. Samples having epithelioid cell granuloma with or without necrosis show AFB positive in 5 (16.66%) and 2 (25%) cases and mycobacteria isolated in 22 (73.73%) and 5 (62.5%) cases respectively. Conclusion-In spite of the diagnostic pitfalls, the outcomes of this study reinforce the importance of opinion i.e. Fine Needle Aspiration Cytology serves as a potent and accurate diagnostic tool forpatients presenting with Lymphadenopathy due to tuberculosis.

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“…The pharmacokinetics of rifampin and isoniazid are influenced by meals,[56] and 50% of the patients are at risk of having sub-optimal concentration if rifampin is taken with food. [57] Carbohydrates and proteins seem to have virtually no influence, but a fatty meal reduces serum concentrations considerably. [58] Prokinetic drugs and antacids containing aluminum and magnesium reduce the absorption of rifampicin.…”

Section: Ensuring Adequate Absorption Of Anti-tb Therapymentioning

confidence: 99%

Tuberculosis chemotherapy in the 21 ^st century: Back to the basics

Joshi

2011

Lung India

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The key to successful elimination of tuberculosis (TB) is treatment of cases with optimum chemotherapy. Poor chemotherapy over time has led to drug-resistant disease. Drug resistance of Mycobacterium tuberculosis develops by the selective growth of resistant mutants. The incidence of drug-resistant cases depends on the number of bacilli and the drug-resistant mutants in the lesion. The latter is low for individual drugs and even lower for two and three drugs. Therefore, use of combination chemotherapy with three or more drugs results in cure. However, irregular treatment, inadequate drugs, inadequate drug doses or addition of a single drug to a failing regimen allows selective growth of resistant mutants and acquired drug-resistant TB. Contacts of these resistant cases develop primary drug resistant TB. Thus, drug resistance in tuberculosis is a “man-made problem”. Anti-TB chemotherapy must be given optimally by (i) ensuring adequate absorption of drugs, (ii) timely diagnosis and management of drug toxicities and (iii) treatment adherence. New classes of anti-TB drugs are needed; but are unlikely to become available soon. It is vital that the 21st century physicians understand the basic principles of TB chemotherapy to ensure efficient use of available drugs to postpone or even reverse epidemics drug-resistant TB.

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Dietary constituents and rifampicin absorption

Cited by 9 publications

References 2 publications

Addressing Tuberculosis in the Context of Malnutrition and HIV Coinfection

Addressing Tuberculosis in the Context of Malnutrition and HIV Coinfection

Efficacy of Fine Needle Aspiration Cytology, Ziehl-Neelsen (Z-N) Stain and Culture (Bactec) in Diagnosis of Tuberculosis Lymphadenitis

Tuberculosis chemotherapy in the 21 ^st century: Back to the basics

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Dietary constituents and rifampicin absorption

Cited by 9 publications

References 2 publications

Addressing Tuberculosis in the Context of Malnutrition and HIV Coinfection

Addressing Tuberculosis in the Context of Malnutrition and HIV Coinfection

Efficacy of Fine Needle Aspiration Cytology, Ziehl-Neelsen (Z-N) Stain and Culture (Bactec) in Diagnosis of Tuberculosis Lymphadenitis

Tuberculosis chemotherapy in the 21 st century: Back to the basics

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Tuberculosis chemotherapy in the 21 ^st century: Back to the basics