Dietary Conjugated Linoleic Acid Normalizes Impaired Glucose Tolerance in the Zucker Diabetic Fattyfa/faRat

Houseknecht, Karen L.; Heuvel, John P. Vanden; Moya-Camarena, Silvia Y.; Portocarrero, Carla; Peck, Louise; Nickel, Kwangok P.; Belury, Martha A.

doi:10.1006/bbrc.1998.8840

Cited by 109 publications

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“…8,9 In the present investigation, some improvements in the deranged metabolic regulation of the female obese Zucker rat were elicited at a substantially lower dose of CLA (0.3 mg/kg). For example, the low-dose CLA treatment caused decreases in fasting plasma glucose and FFAs (Table 1), improved whole-body glucose tolerance and insulin sensitivity (Fig 2), and increased insulin-mediated glucose transport activity in fast-glycolytic muscle (Fig 3).…”

Section: Discussionmentioning

confidence: 58%

“…8,9 These CLA-induced improvements in glucose metabolism were possibly related to a decrease in muscle oxidative stress (Figs 4 and 6). However, recent studies by Riserus et al 39,40 in abdominally obese human males have indicated that treatment with CLA (specifically the trans-10, cis-12 isomer) actually worsened slightly insulin resistance (19%) and glycemia (4%) and was associated with an increase in oxidative stress (based on plasma isoprostanes).…”

Section: Discussionmentioning

confidence: 86%

“…CLA is a naturally occurring compound found in the meat and milk of ruminating animals. In addition to its actions against cancer, 6 CLA has been shown to also have anti-obesity 7 and antidiabetic 8,9 effects and to mediate a repartitioning of the fat-to-lean mass ratio. [10][11][12] CLA is thought to act through the peroxisome proliferator-activated receptor-␥ (PPAR-␥) to elicit the beneficial effects in animal models of diabetes.…”

mentioning

confidence: 99%

“…[10][11][12] CLA is thought to act through the peroxisome proliferator-activated receptor-␥ (PPAR-␥) to elicit the beneficial effects in animal models of diabetes. 8 In addition, CLA displays antioxidant properties, 13 and its ability to neutralize reactive oxygen species may be responsible for at least some of its beneficial metabolic effects.…”

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confidence: 99%

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Interactions of conjugated linoleic acid and lipoic acid on insulin action in the obese Zucker rat

et al. 2003

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The fatty acid conjugated linoleic acid (CLA) and the antioxidant R-(؉)-␣-lipoic acid (R-ALA) individually enhance glucose tolerance and insulin action on skeletal muscle glucose transport in the insulin-resistant obese Zucker rat. To date, no study has assessed the potential interactions between these 2 interventions in treating insulin resistance. The present study was designed to determine whether chronic treatment with CLA and R-ALA in combination would enhance skeletal muscle glucose transport to a greater extent than either intervention individually. CLA, R-ALA, or a combination treatment of R-ALA and CLA were administered to female obese Zucker rats for 20 days at low or high doses. Whereas low-dose R-ALA (10 mg/kg body weight) alone did not alter muscle glucose transport, low-dose CLA (0.3 g/kg) induced a significant increase (38%, P < .05) in insulin-mediated glucose transport in epitrochlearis, but not in soleus. Low-dose combination therapy brought about the greatest enhancement of insulin-mediated glucose transport in epitrochlearis (77%) and soleus (54%), with the latter effect being associated with a 50% reduction in protein carbonyls (an index of tissue oxidative stress) and a 33% diminution in muscle triglycerides. High-dose treatments with CLA (1.5 g/kg), R-ALA (50 mg/kg), and the combination of CLA and R-ALA elicited increases in insulin-mediated glucose transport in epitrochlearis (57%, 58%, and 77%) and soleus (32%, 35%, and 54%). However, whereas the individual high-dose treatments with CLA and R-ALA reduced protein carbonyls (63% and 49%) and triglycerides (29% and 28%) in soleus, no further reductions were observed with the high-dose combination treatment groups. These findings support a significant interaction between low doses of CLA and R-ALA for enhancement of insulin action on skeletal muscle glucose transport, possibly via reductions in muscle oxidative stress and in lipid storage.

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Section: Discussionmentioning

confidence: 58%

Section: Discussionmentioning

confidence: 86%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Interactions of conjugated linoleic acid and lipoic acid on insulin action in the obese Zucker rat

et al. 2003

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“…CLA has many important properties that regulate physiological and metabolic responses, for example, immune modulation, anti-cancer effects, prevention of cardiovascular disease and diabetes, and weight control (Ip et al, 1991;Houseknecht et al, 1998;Islam et al, 2010;Eftekhari et al, 2013;Kim et al, 2013). In animal production, studies on the effects of CLA on immune function have thus far been conducted in the normal physiological status or inflammatory challenge status (O'Shea et al, 2004;Lai et al, 2005;Zhang et al, 2005;Renner et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Effects of dietary conjugated linoleic acids on cellular immune response of piglets after cyclosporin A injection

Liu

Zhu

Liu³

et al. 2016

Animal

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The present study investigated the effects of dietary conjugated linoleic acid (CLA) on the cellular immune response of piglets after cyclosporin A (CsA) treatment. The experimental study had a 2 × 2 factorial design, and the main factors consisted of diets (0% or 2% CLA) and immunosuppression treatments (CsA or saline injection). CsA injection significantly increased feed : gain (F : G) of piglets ( P < 0.05); however, dietary CLA significantly decreased F : G of piglets ( P < 0.05). Dietary CLA partly ameliorated the deterioration of the feed conversion rate caused by CsA treatment ( P < 0.01). CsA treatment significantly decreased the percentages of CD4 + and CD8 + T lymphocytes in the thymus ( P < 0.01). Dietary CLA increased the percentages of CD4 + CD8 + double-positive and CD8 + single-positive T lymphocytes in the thymus ( P < 0.05), and had the trend to inhibit the decrease of CD4 + T lymphocytes in the thymus after CsA injection (P = 0.07). CsA treatment significantly depleted the peripheral blood CD3 + , CD4 + and CD8 + T lymphocytes ( P < 0.01). Dietary CLA significantly increased the number of peripheral blood CD8 + T lymphocytes and interleukin-2 (IL-2) production ( P < 0.05), and inhibited the decreases of peripheral blood CD3 + , CD4 + and CD8 + T lymphocytes counts ( P < 0.01) as well as IL-2 production ( P < 0.05) after CsA treatment. Dietary CLA partly rescued the decrease of lymphocyte proliferation after CsA injection ( P < 0.05). In summary, dietary CLA effectively ameliorated CsA-induced cellular immunosuppression in piglets.

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Fatty acids as regulators of lipid metabolism

Wolfrum

Spener

2000

Eur. J. Lipid Sci. Technol.

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Fatty acids as regulators of lipid metabolismStructurally defined fatty acid species, which are the straight-chain monounsaturated and polyunsaturated and the branched-chain building blocks of dietary fats and oils, have the potential to regulate lipid metabolism. Focussing on the situation in rodents and in man we describe first the non-enzymic proteins that confer regulatory properties to fatty acids. These are the ligand activated receptors in the nuclei (peroxisome proliferator activated receptors, hepatic nuclear factor 4, liver-X-receptor), sterol regulatory element binding proteins and the soluble and membrane-bound transport proteins for fatty acids and derivatives (fatty acid binding proteins, acyl-CoA binding protein, fatty acid translocator, fatty acid translocator proteins). Then we follow the path of the dietary fatty acids from digestion to their ultimate fate in the cell and critically address their regulatory roles. Fatty acids and/or derivatives interact either directly with enzymes to affect activity, or with the nuclear transcription factors, or affect the stability of mRNAs encoding proteins involved in lipid metabolism. Knowledge of the effects of fatty acid species on the genetic machinery as a whole could become a starting point for individualization of nutritional needs.

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Dietary Conjugated Linoleic Acid Normalizes Impaired Glucose Tolerance in the Zucker Diabetic Fattyfa/faRat

Cited by 109 publications

References 0 publications

Interactions of conjugated linoleic acid and lipoic acid on insulin action in the obese Zucker rat

Interactions of conjugated linoleic acid and lipoic acid on insulin action in the obese Zucker rat

Effects of dietary conjugated linoleic acids on cellular immune response of piglets after cyclosporin A injection

Fatty acids as regulators of lipid metabolism

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