Dietary chromium supplementation for targeted treatment of diabetes patients with comorbid depression and binge eating

Brownley, Kimberly A; Boettiger, Charlotte A.; Young, Laura; Cefalu, William T.

doi:10.1016/j.mehy.2015.03.020

Cited by 17 publications

(11 citation statements)

References 83 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Chromium picolinate appears to be especially effective for patients with binge eating disorder and depression 62. Unfortunately as is the case of many supplements, at the present time we are lacking large controlled studies using these supplements.…”

Section: Sugar Addiction Might Predispose To Drug Addictionmentioning

confidence: 97%

Sugar addiction: is it real? A narrative review

DiNicolantonio

O’Keefe

Wilson³

2017

Br J Sports Med

View full text Add to dashboard Cite

In animal studies, sugar has been found to produce more symptoms than is required to be considered an addictive substance. Animal data has shown significant overlap between the consumption of added sugars and drug-like effects, including bingeing, craving, tolerance, withdrawal, cross-sensitisation, cross-tolerance, cross-dependence, reward and opioid effects. Sugar addiction seems to be dependence to the natural endogenous opioids that get released upon sugar intake. In both animals and humans, the evidence in the literature shows substantial parallels and overlap between drugs of abuse and sugar, from the standpoint of brain neurochemistry as well as behaviour.

show abstract

Section: Sugar Addiction Might Predispose To Drug Addictionmentioning

confidence: 97%

Sugar addiction: is it real? A narrative review

DiNicolantonio

O’Keefe

Wilson³

2017

Br J Sports Med

View full text Add to dashboard Cite

show abstract

“…It is known that diabetes mediates neuroinflammation (Wong et al., 2018) and a detailed discussion is provided in the article. Binge eating is linked to abnormal mesolimbic dopaminergic transmission orchestrated by disrupted insulin signaling (Brownley et al., 2015). This adds another rung to the depressive ladder that leads to the development of T2DM and vice versa.…”

Section: Physiological Factors That Play Key Roles In the Comorbiditymentioning

confidence: 99%

Pathophysiology linking depression and type 2 diabetes: Psychotherapy, physical exercise, and fecal microbiome transplantation as damage control

Subba

Sandhir

Singh

et al. 2021

Eur J of Neuroscience

View full text Add to dashboard Cite

Diabetes increases the likelihood of developing depression and vice versa. Research on this bidirectional association has somewhat managed to delineate the interplay among implicated physiological processes. Still, further exploration is required in this context. This review addresses the comorbidity by investigating suspected common pathophysiological mechanisms. One such factor is psychological stress which disturbs the hypothalamic–pituitary–adrenal axis causing hormonal imbalance. This includes elevated cortisol levels, a common biomarker of both depression and diabetes. Disrupted insulin signaling drives the hampered neurotransmission of serotonin, dopamine, and norepinephrine. Also, adipokine hormones such as adiponectin, leptin, and resistin and the orexigenic hormone, ghrelin, are involved in both depression and T2DM. This disarray further interferes with physiological processes encompassing sleep, the gut–brain axis, metabolism, and mood stability. Behavioral coping mechanisms, such as unhealthy eating, mediate disturbed glucose homeostasis, and neuroinflammation. This is intricately linked to oxidative stress, redox imbalance, and mitochondrial dysfunction. However, interventions such as psychotherapy, physical exercise, fecal microbiota transplantation, and insulin‐sensitizing agents can help to manage the distressing condition. The possibility of glucagon‐like peptide 1 possessing a therapeutic role has also been discussed. Nonetheless, there stands an urgent need for unraveling new correlating targets and biological markers for efficient treatment.

show abstract

“…More than 30% of residents present with depressive symptoms and decreased physical, cognitive and social function (Fiocco & Mallya, ). Consequently, residents are less likely to adhere to treatment regimens and physical activity recommendations, which can result in poor management of blood sugar levels (Asuzu, Walker, Williams, & Egede, ; Brownley, Boettiger, Young, & Cefalu, ; Gonzalez et al, ; Indelicato et al, ; Khullar et al, ; Retornaz et al, ).…”

Section: Introductionmentioning

confidence: 99%

Effect of a mindfulness programme for long‐term care residents with type 2 diabetes: A cluster randomised controlled trial measuring outcomes of glycaemic control, relocation stress and depression

Chen

Lin

Atherton

et al. 2020

Int J Older People Nursing

View full text Add to dashboard Cite

Aims The aim of this study was to determine physical, behavioural and psychosocial effects of a newly developed mindfulness programme for older adults with type 2 diabetes relocating to long‐term care facility. Background Taiwan is viewed as an “aged society” with significant proportion of the population living in a long‐term care facility. Approximately one third of residents living in long‐term care facilities have been diagnosed with type 2 diabetes, and disruption to management of their glycaemic levels is at risk for up to one year after relocating to a long‐term care facility. Design A cluster randomised controlled trial was used to examine the effects of a newly developed mindfulness programme on outcomes of glycaemic levels, relocation stress and depression. Methods A total of 140 participants were recruited from six long‐term care facilities in Southern Taiwan. A mindfulness programme was delivered over 9 weeks and consisted of meditations, education and exercise techniques that were delivered by a Registered Nurse trained in mindfulness strategies. Participants in the control group received routine care as provided in the facilities, including routine check‐ups at diabetes clinics as necessary. Data were analysed by Johnson–Neyman technique and generalised estimating equations. Results In total, 120 residents completed the study. The majority of patients were female (64.8%), and 83.5% of the sample were financially supported by their children. The results showed significant improvements in glycated haemoglobin (HbA1c), relocation stress (Wald χ2 = 78.91) and depression (Wald χ2 = 45.70) between groups. In the intervention group, the mean of HbA1c levels showed 16.4% reduction (Mean differences = 1.3; SD = 0.3). However, there were no significant differences in relocation stress and depression within groups. Conclusion The results provided positive effects of the mindfulness programme for older people with diabetes moving into long‐term care facilities. The programme will assist in future planning for diabetes care in long‐term care facilities. Implications for practice To incorporate the mindfulness program into existing diabetes education programs for older people living in LTCFs. Further investigation on the sustainability of the mindfulness program is warranted.

show abstract

Dietary chromium supplementation for targeted treatment of diabetes patients with comorbid depression and binge eating

Cited by 17 publications

References 83 publications

Sugar addiction: is it real? A narrative review

Sugar addiction: is it real? A narrative review

Pathophysiology linking depression and type 2 diabetes: Psychotherapy, physical exercise, and fecal microbiome transplantation as damage control

Effect of a mindfulness programme for long‐term care residents with type 2 diabetes: A cluster randomised controlled trial measuring outcomes of glycaemic control, relocation stress and depression

Contact Info

Product

Resources

About