Dietary cholesterol and cardiovascular disease: a systematic review and meta-analysis

Berger, Samantha; Raman, Gowri; Vishwanathan, Rohini; Jacques, Paul F.; Johnson, Elizabeth J.

doi:10.3945/ajcn.114.100305

Cited by 294 publications

(204 citation statements)

References 70 publications

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“…Although rich in healthy food components such as phospholipids, the carotenoids lutein and zeaxanthin, and many vitamins, the high content of dietary cholesterol in eggs has garnered the most attention with respect to health. Meta-analyses of intervention trials have shown that an increased intake of dietary cholesterol increases serum total, LDL, and HDL cholesterol concentrations, as well as the ratio of total and LDL cholesterol to HDL cholesterol (1,2). However, findings from trials of the effects of high egg consumption on lipid profile concentrations have not been consistent.…”

Section: Introductionmentioning

confidence: 99%

Egg consumption and risk of heart failure, myocardial infarction, and stroke: results from 2 prospective cohorts

Larsson

Åkesson

Wolk

2015

The American Journal of Clinical Nutrition

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Section: Introductionmentioning

confidence: 99%

Egg consumption and risk of heart failure, myocardial infarction, and stroke: results from 2 prospective cohorts

Larsson

Åkesson

Wolk

2015

The American Journal of Clinical Nutrition

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“…In such studies, however, greater doses of cholesterol than the average Japanese intake have typically been employed as intervention. The mean cholesterol intakes of Japanese adults are 338 mg/d for men and 279 mg/d for women (1), while the doses used in many trials ranged from 500 to 1,400 mg/d (2). Thus, further trials with moderate cholesterol intakes are indispensable to better understand the possible effects of typical cholesterol intakes in healthy populations.…”

mentioning

confidence: 99%

The Effect of the Consumption of Egg on Serum Lipids and Antioxidant Status in Healthy Subjects

Kishimoto

Taguchi

Suzuki-Sugihara

et al. 2016

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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SummaryThe egg is a nutrient-dense food and contains a number of antioxidants. The consumption of eggs has been considered to improve the balance of diets, although its impact on serum cholesterol levels has been a matter of concern in many countries. Here, we conducted a pilot study to investigate whether daily additional consumption of an egg might affect serum lipid profiles and also antioxidant status in healthy subjects. Fourteen male subjects were provided with breakfasts including a boiled egg for 4 wk. At the end of intervention, serum concentrations of total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) were unchanged, despite the significant increase in the intake of dietary cholesterol. In contrast, a significant increase in high-density lipoprotein cholesterol (HDL-C) and a reduction of the LDL-C/HDL-C ratio were observed. Interestingly, the malondialdehyde modified-LDL (MDA-LDL)/LDL-C ratio and the oxidizability of LDL were significantly reduced. Serum total antioxidant capacity value after the intervention period was higher than at baseline. These data indicate that consuming one egg per day for 4 wk as breakfast in addition to a normal diet does not affect serum lipids, and suggests that it may improve serum antioxidant status in healthy males.

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“…Diabetes mellitus is one of the risk factors that can cause atherosclerosis. 8 LDL cholesterol levels play a major role in the incidence of cardiovascular disease. Based on the results of this study, 96% subjects had LDL level > 100 mg.dl.…”

Section: Results Dan Discussionmentioning

confidence: 99%

The Risk of Atherosclerotic Cardiovascular Disease among Hyperlipidaemia Patients and Appropriateness of Statin Therapy

Iskandar

Nurmainah

Susanti³

2018

PCPR

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Patients with hyperlipidaemia is at increased risk of developing atherosclerotic cardiovascular disease (ASCVD). The use of appropriate statin therapy is important to obtain optimal health outcomes. However, there was limited information regarding the risk of ASCVD among Indonesian hyperlipidaemia population and the appropriateness of statin therapy given to these patients. This study aimed to assess the ASCVD risks among the patients and evaluate the use of statin therapy at hospitalized hyperlidaemia patients. This cross sectional study used medical records as data source. This study was conducted at one hospital in Pontianak, Indonesia during Januari-June 2017. We included 50 subjects. The 10-year risk of ASCVD was assessed using ASCVD pooled cohort risk assessment equation (PCRAE). The results showed that 66% of the included subjects had a relatively high risk of developing ASCVD. Subjects with high risk of ASCVD received inappropriate statin therapy. High intensity statin should be given to these patients. In conclusion, large proportion of the subjects were at high risk of developing ASCVD. Nevertheless, inappropriate statin therapy were given to these patients. Improvement in medication practice should be done to prevent complication and increase quality of health outcomes.

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Dietary cholesterol and cardiovascular disease: a systematic review and meta-analysis

Abstract: Reviewed studies were heterogeneous and lacked the methodologic rigor to draw any conclusions regarding the effects of dietary cholesterol on CVD risk. Carefully adjusted and well-conducted cohort studies would be useful to identify the relative effects of dietary cholesterol on CVD risk.

Cited by 294 publications

References 70 publications

Egg consumption and risk of heart failure, myocardial infarction, and stroke: results from 2 prospective cohorts

Egg consumption and risk of heart failure, myocardial infarction, and stroke: results from 2 prospective cohorts

The Effect of the Consumption of Egg on Serum Lipids and Antioxidant Status in Healthy Subjects

The Risk of Atherosclerotic Cardiovascular Disease among Hyperlipidaemia Patients and Appropriateness of Statin Therapy

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