Dietary cholesterol affects lipid metabolism in rabbits

Abstract

Summary and ImplicationsEffects of dietary cholesterol (0 (control), 1, 2, 4 or 8 g cholesterol/kg diet for 12 wks) on lipid contents and fatty acid compositions in red blood cell (RBC) membranes and plasma of rabbits and pathological changes and lipid oxidation in their livers were determined. Contents of total lipid and unsaturated fatty acids in RBC membrane and plasma of rabbits fed ≥4 g and ≥2 g dosages, respectively, were significantly higher (P < 0.05) than those of the control, and their increases were dosage-dependent. Accumulations of neutral lipids in centrolobular regions of livers in rabbits fed ≥ 2 g were dosage-dependent. Lipid oxidation in liver of rabbits fed 8 g was >2 times higher (P < 0.05) than those fed lower dosages. The results indicated that dietary cholesterol can modify lipid metabolisms of rabbits, including biosynthesis and transportation of lipids and fatty acids and incorporation of fatty acid into RBC membranes.

Lignin-grafting alternative copolymer of 3,4-dihydrocoumarin and epoxides as an active and flexible ingredient in sunscreen

“…43 In fixed reaction time mode, the time duration (20–30 min) is usually considered as an estimate of antioxidant properties. 69 It is clear that different times were necessary to reach a steady state for antioxidants; therefore, the free-radical scavenging reaction can be categorized as slow, medium or fast. 70 As shown in Fig.…”

Effects of Dietary Cholesterol and Its Oxidation Products on Pathological Lesions and Cholesterol and Lipid Oxidation in the Rabbit Liver

“…The percentage of palmitoleic acid and linolenic acid increased ( P < 0.05), whereas that of stearic acid and arachidonic acid decreased ( P < 0.05) with an increase in dietary CHO and COPs. The reason why unsaturated fatty acids are increased by dietary CHO and COPs remains unclear, but the changes in lipid composition induced by dietary CHO may be caused by compensatory mechanisms initiated to maintain lipid homeostasis in cellular aspects such as membrane fluidity [ 20 ].…”

Effects of Dietary Cholesterol and its Oxidation Products on Pathological Lesions and Cholesterol and Lipid Oxidation in the Rabbit Liver

“…The percentage of palmitoleic acid and linolenic acid increased ( < 0.05), whereas that of stearic acid and arachidonic acid decreased ( < 0.05) with an increase in dietary CHO and COPs. The reason why unsaturated fatty acids are increased by dietary CHO and COPs remains unclear, but the changes in lipid composition induced by dietary CHO may be caused by compensatory mechanisms initiated to maintain lipid homeostasis in cellular aspects such as membrane fluidity [20].…”