Dietary carotenoid intake and osteoporosis: the National Health and Nutrition Examination Survey, 2005–2018

Kan, Bo; Guo, Dingjie; Yuan, Baoming; Vuong, Ann M.; Jiang, Depeng; Zhang, Mengmeng; Cheng, Haitao; Zhao, Qianqian; Li, Binbin; Feng, Lijie; Huang, Fei; Wang, Na; Shen, Xue; Yang, Shuman

doi:10.1007/s11657-021-01047-9

Cited by 23 publications

(18 citation statements)

References 31 publications

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“…Data were collected and screened from the NHANES. The NHANES is a representative multilevel and multidimensional project, its continuity is due to the organization’s annual survey of a sample of the American people ( 15 , 16 ). Participants completed the NHANES and signed an informed consent.…”

Section: Methodsmentioning

confidence: 99%

Association between osteoporosis or osteopenia and taking antiplatelet agents in general US population of NHANES

Wang

Zhu

et al. 2022

Front. Endocrinol.

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BackgroundOsteoporosis (OP) and osteopenia are common bone disorders in old age, and lots of patients suffering from OP or osteopenia need to take antiplatelet agents to treat basic diseases. However, clinical data on the link between osteopenia or OP and antiplatelet agents are limited.MethodsData in this study were collected and screened from the NHANES from 2013 to 2014 and 2017 to 2018. The variables were extracted from interviews and compared between OP or osteopenia participants and normal. The relationship between OP or osteopenia and taking antiplatelet drugs was analyzed by weighted multivariate logistic regressionResultsAfter excluding individuals who were not eligible and had invalid data, we finally identified 894 participants for inclusion in the study. We found a negative association between OP or osteopenia and taking antiplatelet agents (OR = 0.53; 95% CI, 0.33–0.84; p < 0.05). These results did not change on multiple imputations (OR = 0.32, 95% CI, 0.19–0.56; p <0.01). In the subgroup analyses, the associations were more significant in women (OR = 0.18, 95% CI, 0.05–0.62; p <0.05).ConclusionThis study demonstrated that the association between OP or osteopenia and taking antiplatelet agents was significant. Therefore, it is necessary to confirm the result by extending further research.

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Section: Methodsmentioning

confidence: 99%

Association between osteoporosis or osteopenia and taking antiplatelet agents in general US population of NHANES

Wang

Zhu

et al. 2022

Front. Endocrinol.

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“…In addition to previous studies, a cross-sectional analysis of data from the NHANES 2005–2018 survey, which included 4820 people aged 50 or older, showed that individuals with higher β-carotene and β-cryptoxanthin intake had a lower prevalence of osteoporosis compared to those with lower intake. Furthermore, higher β-carotene intake was found to be associated with higher total hip and lumbar spine BMD [ 20 ]. These findings suggest that increasing the intake of foods that are rich in β-carotene and β-cryptoxanthin, such as carrots, sweet potatoes, and citrus fruits, may have a positive impact on bone health and potentially reduce the risk of osteoporosis in older adults.…”

Section: Discussionmentioning

confidence: 99%

“…Although fruit and vegetable intake are commonly associated with positive health outcomes, research findings on their effect on bone health are conflicting [ 10 , 11 , 12 ]. However, individual phytochemicals, which are plant-based chemical compounds abundant in fruits and vegetables, such as isoflavones, polyphenols, genistein, lycopene, and carotenoids, have been shown to enhance bone mineral density (BMD) and osteogenesis [ 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 ]. These phytochemicals have various mechanisms of action that contribute to their beneficial effects, including inhibiting osteoclast formation and reducing cytokine damage, promoting bone cell growth, and reducing bone resorption markers.…”

Section: Introductionmentioning

confidence: 99%

Association between Phytochemical Index and Osteoporosis in Women: A Prospective Cohort Study in Korea

Yoo

Park

2023

Nutrients

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Osteoporosis is a prevalent issue among postmenopausal women, who have a higher incidence of the condition than men. This study aimed to examine the relationship between phytochemical-rich food intake and osteoporosis incidence in premenopausal and postmenopausal women. The data analyzed included 4600 women aged 40–69 who were free of osteoporosis at baseline, with dietary intake evaluated through a semi-quantitative food frequency questionnaire and osteoporosis prevalence determined using interviewer-administered questionnaires and bone mineral density tests. The phytochemical index (PI) was calculated to reflect the intake levels of phytochemical-rich foods. Postmenopausal women in the highest PI quartile had a 16% lower risk of osteoporosis (95% confidence interval (CI): 0.71 to 0.99, p for trend = 0.02) than those in the lowest quartile, while no significant association was observed among premenopausal women (hazard ratio: 0.98, 95% CI: 0.78 to 1.24, p for trend = 0.8). These findings suggest that consuming phytochemical-rich foods may have a protective effect against osteoporosis in postmenopausal women, offering valuable scientific insights. However, additional research is needed to validate these findings using biochemical data. Overall, this study highlights the potential of dietary interventions to reduce the risk of osteoporosis in postmenopausal women.

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“…The covariates were selected based on a literature review of published studies that investigated the association between nutrient intake (eg, copper, zinc, carotenoids, and vitamin E) and osteoporosis using the NHANES database. 16,[25][26][27] Of the variables, total energy intake and supplement use were selected based on studies that examined the association between CDAI and health outcomes. 14 Given that the CDAI was based on nutrient synthesis through food intake alone and that nutrient intake varies with total energy intake, we adjusted for monthly supplement use and total energy intake.…”

Section: Covariatesmentioning

confidence: 99%

“…This index has been widely used to study the relationship between dietary antioxidants and health outcomes including those of lung cancer and cognitive disorders 13,14 . To date, several studies have investigated the relationship between single dietary antioxidant vitamins or minerals and bone health 15–17 . However, no study has used the CDAI to evaluate total dietary antioxidant intake (because of its association with BMD) and the likelihood of osteoporosis.…”

mentioning

confidence: 99%

Composite dietary antioxidant intake and osteoporosis likelihood in premenopausal and postmenopausal women: a population-based study in the United States

Zhang

Wei

et al. 2023

Menopause

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Objective: Osteoporosis is a skeletal disease characterized by low bone mass, reduced bone strength, and increased fracture risk. We aimed to investigate the association between combined dietary antioxidant intake and the likelihood of osteoporosis in premenopausal and postmenopausal women, based on data from the National Health and Nutrition Examination Survey.Methods: Nutrient intake data were obtained using two 24-hour recalls. Composite dietary antioxidant index (CDAI), which refers to the intake amounts of β-carotene, vitamin A, vitamin C, vitamin E, selenium, zinc, copper, and iron, was then constructed. Prevalent osteoporosis was defined according to bone mineral density T scores of ≤ −2.5 and self-reports. Multiple logistic and Poisson regression models were used for association analyses.Results: A total of 3,418 participants (1,157 premenopausal and 2,261 postmenopausal women) 40 years or older were included, 776 (22.70%) of whom had prevalent osteoporosis. In terms of individual nutrients, postmenopausal women in the highest CDAI quartiles for dietary β-carotene, vitamin A, vitamin C, and iron intakes had a low likelihood of osteoporosis. Regarding the CDAI-osteoporosis association, postmenopausal women in the highest quartile were less likely to have osteoporosis (OR Q3vsQ1 , 0.64; 95% CI, 0.43-0.96; OR Q4vsQ1 , 0.56; 95% CI, 0.35-0.89; P for trend = 0.013), after controlling for covariates.Conclusions: CDAI was negatively associated with the likelihood of osteoporosis in postmenopausal women. Our findings suggest that the combined intake of antioxidant nutrients can help reduce the likelihood of osteoporosis in women.

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Dietary carotenoid intake and osteoporosis: the National Health and Nutrition Examination Survey, 2005–2018

Cited by 23 publications

References 31 publications

Association between osteoporosis or osteopenia and taking antiplatelet agents in general US population of NHANES

Association between osteoporosis or osteopenia and taking antiplatelet agents in general US population of NHANES

Association between Phytochemical Index and Osteoporosis in Women: A Prospective Cohort Study in Korea

Composite dietary antioxidant intake and osteoporosis likelihood in premenopausal and postmenopausal women: a population-based study in the United States

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