Dietary carbohydrates and intestinal lipoprotein production

Abstract

Sugar in the diet enhances dietary fat absorption and chylomicron secretion. Whether this phenomenon contributes quantitatively to the well described hypertriglyceridemia that occurs with diets high in carbohydrate and low in fat requires further investigation, as does the underlying cellular mechanism. A thorough understanding of this phenomenon could provide useful information to optimize dietary guidelines.

Diabetic Dyslipidaemia

“…Given that the increasing prevalence of T2D and the metabolic syndrome in North America closely mirrors the increased consumption of refined carbohydrates and simple sugars over the twentieth century, both lipid and carbohydrate ingestion appear to be important contributors to the hypertriglyceridaemia and CM overproduction observed in these states (Morgantini et al, 2014). CM lipidation increases with the amount of fat consumed, and meals rich in monounsaturated, polyunsaturated and saturated fatty acids can differentially affect the number, size and clearance of CM particles .…”

Intravenous Glucose Acutely Stimulates Intestinal Lipoprotein Secretion in Healthy Humans

“…15 Such effects were mostly attributed to increased VLDL secretion, with increased triglyceride and in some studies increased apoB production, along with impaired clearance. 15 However, recent evidence suggests that TRL secretion from the intestine also responds to carbohydrates. Furthermore, a single glucose drink is able to release intestinal lipid storage originating from an earlier meal.…”

“…10,11 It has long been recognized that high carbohydrate diets and refined sugars exacerbate postprandial lipid responses and promote metabolic abnormalities. [12][13][14][15] High dietary carbohydrates promote fasting and postprandial hypertriglyceridemia during chronic and some, but not all, acute studies. 15 Such effects were mostly attributed to increased VLDL secretion, with increased triglyceride and in some studies increased apoB production, along with impaired clearance.…”

“…[12][13][14][15] High dietary carbohydrates promote fasting and postprandial hypertriglyceridemia during chronic and some, but not all, acute studies. 15 Such effects were mostly attributed to increased VLDL secretion, with increased triglyceride and in some studies increased apoB production, along with impaired clearance. 15 However, recent evidence suggests that TRL secretion from the intestine also responds to carbohydrates.…”

The Beriberi Heart

“…Epidemiological studies reveal that the increase in dietary sugars and refined carbohydrates are associated with the rising prevalence of the metabolic syndrome and type 2 diabetes (22). The highly processed, calorie-dense, nutrient-depleted diet favored in the current American culture frequently leads to exaggerated supraphysiological post-prandial dysmetabolism.…”